Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Cot-Tpl2 Inhibitor Compound 38 (Abbott) C21H12F3N5OS 439.41 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 4952-4955 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 31 1
MKK2 70 7
MKK6 100 4
ERK1 82 9
ERK2 95 5
JNK1 101 3
JNK2 100 5
JNK3 96 7
p38 alpha MAPK 107 1
p38 beta MAPK 100 2
p38 gamma MAPK 73 13
p38 delta MAPK 77 4
ERK8 4 1
RSK1 57 1
RSK2 88 6
PDK1 97 3
PKB alpha 73 1
PKB beta 98 6
SGK1 39 4
S6K1 50 5
PKA 89 0
ROCK 2 93 12
PRK2 54 5
PKC alpha 59 1
PKC zeta 60 5
PKD1 95 3
MSK1 22 3
MNK1 55 0
MNK2 64 1
MAPKAP-K2 94 5
MAPKAP-K3 95 6
PRAK 67 1
CAMKK beta 44 4
CAMK1 73 3
SmMLCK 42 5
PHK 82 0
DAPK1 17 0
CHK1 65 5
CHK2 37 8
GSK3 beta 14 1
CDK2-Cyclin A 47 4
PLK1 16 1
Aurora A 63 2
Aurora B 40 5
LKB1 64 5
AMPK 51 1
MARK1 72 1
MARK2 84 2
MARK3 51 3
MARK4 97 11
BRSK1 104 12
BRSK2 105 0
MELK 19 7
NUAK1 88 4
CK1 delta 41 3
CK2 4 0
DYRK1A 5 1
DYRK2 3 1
DYRK3 3 1
NEK2a 113 14
NEK6 83 13
IKK beta 56 6
IKK epsilon 60 0
TBK1 63 6
PIM1 17 1
PIM2 36 1
PIM3 31 2
SRPK1 105 2
EF2K 80 6
HIPK1 12 1
HIPK2 11 2
HIPK3 10 0
CLK2 14 0
PAK2 101 5
PAK4 97 5
PAK5 94 9
PAK6 110 1
MST2 76 5
MST4 71 5
GCK 17 1
MINK1 87 3
MEKK1 93 10
MLK1 91 0
MLK3 61 10
TAO1 30 2
ASK1 72 7
TAK1 67 6
IRAK4 88 12
RIPK2 30 7
TTK 63 1
Src 95 3
Lck 98 7
CSK 95 6
YES1 87 5
BTK 84 3
JAK2 46 1
SYK 102 9
EPH-A2 94 3
EPH-A4 106 1
EPH-B1 100 12
EPH-B2 120 8
EPH-B3 104 11
EPH-B4 110 10
FGF-R1 76 1
HER4 89 3
IGF-1R 74 3
IR 91 1
IRR 27 4
TrkA 71 1
VEGFR1 29 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 87 10
MKK2 87 12
MKK6 94 5
ERK1 101 15
ERK2 114 15
JNK1 103 7
JNK2 113 15
JNK3 85 6
p38 alpha MAPK 102 3
p38 beta MAPK 102 5
p38 gamma MAPK 91 5
p38 delta MAPK 113 1
ERK8 34 3
RSK1 122 3
RSK2 132 2
PDK1 103 2
PKB alpha 99 10
PKB beta 106 1
SGK1 93 10
S6K1 98 1
PKA 101 1
ROCK 2 90 6
PRK2 98 1
PKC alpha 107 3
PKC zeta 126 13
PKD1 109 5
MSK1 90 8
MNK1 89 2
MNK2 105 7
MAPKAP-K2 97 5
MAPKAP-K3 109 7
PRAK 110 4
CAMKK beta 105 6
CAMK1 93 3
SmMLCK 94 1
PHK 102 1
DAPK1 47 1
CHK1 118 9
CHK2 102 1
GSK3 beta 63 6
CDK2-Cyclin A 79 4
PLK1 83 11
Aurora A 108 9
Aurora B 81 3
LKB1 85 1
AMPK 81 8
MARK1 99 0
MARK2 83 6
MARK3 100 12
MARK4 106 12
BRSK1 138 7
BRSK2 115 1
MELK 81 11
NUAK1 128 7
CK1 delta 86 1
CK2 20 2
DYRK1A 27 3
DYRK2 16 1
DYRK3 18 3
NEK2a 108 1
NEK6 93 7
IKK beta 89 3
IKK epsilon 109 5
TBK1 109 15
PIM1 70 3
PIM2 87 14
PIM3 74 0
SRPK1 112 1
EF2K 106 6
HIPK1 65 8
HIPK2 22 2
HIPK3 63 1
CLK2 73 7
PAK2 109 10
PAK4 121 2
PAK5 103 2
PAK6 121 14
MST2 93 2
MST4 118 7
GCK 68 5
MINK1 96 4
MEKK1 109 13
MLK1 126 4
MLK3 91 0
TAO1 65 0
ASK1 95 4
TAK1 104 13
IRAK4 90 1
RIPK2 83 11
TTK 83 11
Src 108 10
Lck 100 2
CSK 100 2
YES1 100 8
BTK 98 1
JAK2 99 2
SYK 114 5
EPH-A2 126 0
EPH-A4 109 4
EPH-B1 108 3
EPH-B2 111 10
EPH-B3 122 4
EPH-B4 109 4
FGF-R1 102 6
HER4 94 0
IGF-1R 74 7
IR 100 10
IRR 67 2
TrkA 104 8
VEGFR1 96 7

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