Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GW501516 C21H18F3NO3S2 453.5 PPARd Sznaidman M.L. (2003) Bioorg Med Chem Lett 13(9) 1517-21 Enzo (Alexis) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 90 1
ERK1 127 24
ERK2 102 2
JNK1 74 9
JNK2 79 14
p38 alpha MAPK 98 2
p38 beta MAPK 94 10
p38 gamma MAPK 106 8
p38 delta MAPK 105 1
ERK8 109 8
RSK1 113 2
RSK2 88 21
PDK1 73 2
PKB alpha 105 9
PKB beta 103 6
SGK1 109 13
S6K1 105 16
PKA 86 4
ROCK 2 91 12
PRK2 92 5
PKC alpha 88 10
PKC zeta 74 3
PKD1 64 1
MSK1 92 7
MNK1 79 2
MNK2 83 19
MAPKAP-K2 84 1
PRAK 39 5
CAMKK beta 83 0
CAMK1 62 13
SmMLCK 74 3
PHK 96 9
CHK1 120 19
CHK2 101 6
GSK3 beta 83 12
CDK2-Cyclin A 81 7
PLK1 60 5
Aurora B 100 3
AMPK 91 7
MARK3 91 5
BRSK2 78 10
MELK 85 2
CK1 delta 80 3
CK2 79 10
DYRK1A 59 2
DYRK2 111 0
DYRK3 81 7
NEK2a 153 0
NEK6 120 20
IKK beta 139 74
IKK epsilon 92 1
TBK1 88 0
PIM1 83 5
PIM2 106 2
PIM3 72 2
SRPK1 87 2
EF2K 88 22
HIPK2 156 5
PAK4 66 4
PAK5 111 5
PAK6 109 6
MST2 122 4
MST4 83 1
Src 70 0
Lck 98 7
CSK 97 1
YES1 102 3
BTK 95 3
SYK 85 9
EPH-A2 113 5
EPH-B3 115 13
FGF-R1 81 7
IGF-1R 67 59
IR 103 16
IRR 95 12
VEGFR1 74 10
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 105 18
ERK1 115 10
ERK2 100 1
JNK1 83 11
JNK2 101 22
p38 alpha MAPK 82 1
p38 beta MAPK 91 5
p38 gamma MAPK 108 14
p38 delta MAPK 102 0
ERK8 103 7
RSK1 106 1
RSK2 94 3
PDK1 96 9
PKB alpha 107 7
PKB beta 103 10
SGK1 111 17
S6K1 98 0
PKA 110 6
ROCK 2 99 18
PRK2 102 5
PKC alpha 96 6
PKC zeta 79 11
PKD1 81 7
MSK1 96 4
MNK1 89 4
MNK2 99 4
MAPKAP-K2 97 12
PRAK 41 39
CAMKK beta 86 5
CAMK1 95 19
SmMLCK 92 1
PHK 109 3
CHK1 102 3
CHK2 81 17
GSK3 beta 87 3
CDK2-Cyclin A 87 14
PLK1 75 3
Aurora B 110 10
AMPK 94 8
MARK3 93 9
BRSK2 91 6
MELK 79 4
CK1 delta 82 12
CK2 84 3
DYRK1A 87 4
DYRK2 103 5
DYRK3 83 6
NEK2a 94 5
NEK6 101 3
IKK beta 220 133
IKK epsilon 92 0
TBK1 102 8
PIM1 79 1
PIM2 99 17
PIM3 86 4
SRPK1 96 7
EF2K 80 1
HIPK2 101 2
PAK4 87 5
PAK5 97 0
PAK6 97 0
MST2 97 9
MST4 104 9
Src 87 5
Lck 106 2
CSK 98 6
YES1 98 2
BTK 92 8
SYK 103 8
EPH-A2 103 8
EPH-B3 122 28
FGF-R1 100 6
IGF-1R 87 2
IR 107 19
IRR 81 12
VEGFR1 84 1

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