Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Caffeine C8H10N4O2 194.19 ATM Islam M.S. (1998) Proc. Natl. Acad. Sci. USA 95 6145-6150 Sigma Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 75 27
ERK1 99 10
ERK2 96 1
JNK1 92 13
JNK2 94 1
p38 alpha MAPK 88 9
p38 beta MAPK 107 5
p38 gamma MAPK 97 7
p38 delta MAPK 88 1
ERK8 88 16
RSK1 74 7
RSK2 98 12
PDK1 97 7
PKB alpha 90 0
PKB beta 81 4
SGK1 102 6
S6K1 100 10
PKA 103 2
ROCK 2 91 2
PRK2 89 12
PKC alpha 101 6
PKC zeta 95 6
PKD1 92 1
MSK1 80 6
MNK1 110 2
MNK2 87 4
MAPKAP-K2 102 10
PRAK 96 0
CAMKK beta 104 3
CAMK1 90 6
SmMLCK 90 1
PHK 113 10
CHK1 88 6
CHK2 86 3
GSK3 beta 102 5
CDK2-Cyclin A 86 1
PLK1 92 5
Aurora B 91 0
AMPK 90 4
MARK3 79 7
BRSK2 99 7
MELK 98 3
CK1 delta 118 10
CK2 115 4
DYRK1A 92 7
DYRK2 81 6
DYRK3 96 16
NEK2a 107 1
NEK6 79 14
IKK beta 90 5
IKK epsilon 87 9
TBK1 92 7
PIM1 90 13
PIM2 113 1
PIM3 99 3
SRPK1 93 5
EF2K 88 1
HIPK2 103 6
PAK4 99 6
PAK5 102 5
PAK6 97 4
MST2 97 8
MST4 96 10
Src 96 2
Lck 88 7
CSK 100 3
YES1 85 0
BTK 79 1
SYK 92 0
EPH-A2 96 4
EPH-B3 92 6
FGF-R1 118 4
IGF-1R 86 0
IR 104 9
IRR 86 8
VEGFR1 80 14
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 75 25
ERK1 113 5
ERK2 101 2
JNK1 78 0
JNK2 100 0
p38 alpha MAPK 89 2
p38 beta MAPK 104 2
p38 gamma MAPK 110 3
p38 delta MAPK 88 2
ERK8 95 2
RSK1 78 2
RSK2 79 8
PDK1 92 1
PKB alpha 101 7
PKB beta 84 5
SGK1 121 34
S6K1 98 3
PKA 96 2
ROCK 2 93 8
PRK2 89 26
PKC alpha 100 3
PKC zeta 88 4
PKD1 92 18
MSK1 82 10
MNK1 99 15
MNK2 91 10
MAPKAP-K2 89 14
PRAK 86 0
CAMKK beta 103 1
CAMK1 101 4
SmMLCK 91 15
PHK 115 12
CHK1 96 16
CHK2 83 2
GSK3 beta 101 10
CDK2-Cyclin A 91 7
PLK1 95 12
Aurora B 83 3
AMPK 98 2
MARK3 79 19
BRSK2 97 4
MELK 90 3
CK1 delta 120 1
CK2 106 8
DYRK1A 96 7
DYRK2 87 10
DYRK3 98 1
NEK2a 102 11
NEK6 89 4
IKK beta 100 8
IKK epsilon 90 8
TBK1 96 8
PIM1 97 8
PIM2 117 21
PIM3 97 6
SRPK1 97 6
EF2K 92 5
HIPK2 112 1
PAK4 100 1
PAK5 114 4
PAK6 101 6
MST2 89 19
MST4 97 7
Src 88 7
Lck 92 2
CSK 103 13
YES1 85 4
BTK 78 4
SYK 86 2
EPH-A2 102 2
EPH-B3 97 8
FGF-R1 112 15
IGF-1R 94 3
IR 98 23
IRR 80 1
VEGFR1 84 17

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