Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Cot-Tpl2 Inhibitor Compound 41 (Abbott) C21H14N6O2S 414.44 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 4952-4955 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
ERK8 2 0
DYRK2 2 0
DYRK1A 3 1
DYRK3 6 2
CK2 6 1
HIPK1 9 2
HIPK2 10 10
GSK3 beta 10 2
HIPK3 10 0
CLK2 12 1
GCK 13 1
PIM2 14 0
PIM1 18 5
DAPK1 18 2
MSK1 20 1
MINK1 21 2
PIM3 21 4
RIPK2 22 1
CAMKK beta 23 2
VEGFR1 24 6
PLK1 24 3
MLK3 25 0
IRR 26 6
PKC alpha 30 1
RSK1 33 7
SmMLCK 35 5
TAO1 36 0
ROCK 2 38 0
MLK1 42 1
RSK2 44 5
SRPK1 48 6
AMPK 49 4
MEKK1 51 7
TTK 51 5
PRK2 53 15
PAK4 54 3
p38 delta MAPK 54 6
PRAK 56 1
Aurora B 58 2
MNK2 58 6
LKB1 59 4
CHK2 59 0
CK1 delta 59 5
MST4 61 6
FGF-R1 61 6
PKB beta 62 2
MELK 62 1
TBK1 63 11
IKK beta 64 1
S6K1 64 13
p38 gamma MAPK 65 7
PAK5 66 6
PKC zeta 67 5
SGK1 68 2
IKK epsilon 69 2
BTK 71 7
MARK3 71 6
PKA 72 1
JNK3 72 6
HER4 73 4
JAK2 74 0
IRAK4 74 2
MST2 75 0
MKK2 75 2
TAK1 75 11
JNK1 77 9
Aurora A 78 1
PKB alpha 78 1
MARK1 78 1
MARK4 78 3
MKK1 78 7
ERK1 78 1
NUAK1 78 1
NEK2a 80 9
PKD1 80 6
MARK2 83 7
MNK1 84 6
PHK 84 1
MAPKAP-K2 85 1
CAMK1 85 6
JNK2 85 3
PAK6 87 3
YES1 87 1
MAPKAP-K3 87 0
CHK1 87 2
TrkA 89 6
EPH-A2 89 4
BRSK1 90 8
PAK2 90 7
PDK1 91 12
Src 92 2
NEK6 94 6
SYK 95 3
BRSK2 95 3
IGF-1R 95 11
ERK2 96 15
EPH-B3 96 12
EPH-B4 96 3
p38 alpha MAPK 98 11
Lck 99 8
MKK6 99 9
EPH-B2 99 8
CSK 100 4
EF2K 101 9
p38 beta MAPK 104 6
CDK2-Cyclin A 105 2
EPH-B1 107 6
IR 108 4
EPH-A4 112 9
ASK1 112 1
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
DYRK2 7 0
DYRK3 15 1
DYRK1A 21 8
CK2 30 3
GSK3 beta 38 2
HIPK2 64 5
PIM1 70 7
ROCK 2 73 5
PKC alpha 76 6
AMPK 77 0
RSK2 77 2
PKB beta 77 14
MELK 77 10
GCK 78 5
TTK 79 1
IRR 79 0
PDK1 79 7
PIM3 79 0
CHK1 79 4
PRK2 80 10
CLK2 80 3
LKB1 80 0
MARK2 80 2
PAK5 81 2
MKK2 81 2
MLK3 81 5
TAK1 82 5
MAPKAP-K3 82 4
TAO1 82 2
TrkA 83 6
Aurora B 84 7
VEGFR1 84 14
CAMKK beta 84 8
MINK1 84 5
Src 85 2
ERK8 85 5
MKK1 85 12
PIM2 85 11
p38 gamma MAPK 86 8
CSK 86 12
MARK4 86 0
SmMLCK 86 11
TBK1 87 2
IRAK4 88 6
HER4 88 11
RSK1 88 1
DAPK1 88 6
PKD1 89 2
PAK4 89 11
PAK6 89 2
MARK1 89 1
IKK epsilon 89 0
CK1 delta 90 2
PLK1 90 1
MSK1 90 9
CDK2-Cyclin A 91 1
YES1 91 10
p38 delta MAPK 92 5
BRSK2 92 6
NUAK1 92 7
PAK2 93 1
MAPKAP-K2 93 1
MST4 93 2
JNK1 93 5
EPH-B3 93 3
RIPK2 94 6
NEK2a 94 5
MNK2 94 0
IKK beta 94 0
MARK3 94 5
EPH-A2 94 8
BTK 95 8
MLK1 95 10
EPH-B1 95 10
HIPK3 96 3
PKB alpha 96 3
S6K1 96 8
ERK2 96 11
CHK2 97 8
EPH-B4 97 0
p38 beta MAPK 97 3
JAK2 97 4
ERK1 97 5
NEK6 98 10
MST2 98 4
JNK2 99 10
MEKK1 99 4
SRPK1 99 7
PKC zeta 100 2
MNK1 100 1
SGK1 100 5
PHK 100 6
EF2K 100 12
Aurora A 103 9
EPH-A4 103 5
PRAK 104 4
MKK6 104 6
HIPK1 104 5
ASK1 104 1
JNK3 105 4
FGF-R1 105 0
CAMK1 105 8
p38 alpha MAPK 106 2
EPH-B2 106 6
IGF-1R 107 15
SYK 107 5
PKA 108 1
BRSK1 110 5
IR 111 10
Lck 113 7

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