Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Cot-Tpl2 Inhibitor Compound 41 (Abbott) C21H14N6O2S 414.44 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 4952-4955 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 12
MKK2 81 2
MKK6 104 6
ERK1 97 5
ERK2 96 11
JNK1 93 5
JNK2 99 10
JNK3 105 4
p38 alpha MAPK 106 2
p38 beta MAPK 97 3
p38 gamma MAPK 86 8
p38 delta MAPK 92 5
ERK8 85 5
RSK1 88 1
RSK2 77 2
PDK1 79 7
PKB alpha 96 3
PKB beta 77 14
SGK1 100 5
S6K1 96 8
PKA 108 1
ROCK 2 73 5
PRK2 80 10
PKC alpha 76 6
PKC zeta 100 2
PKD1 89 2
MSK1 90 9
MNK1 100 1
MNK2 94 0
MAPKAP-K2 93 1
MAPKAP-K3 82 4
PRAK 104 4
CAMKK beta 84 8
CAMK1 105 8
SmMLCK 86 11
PHK 100 6
DAPK1 88 6
CHK1 79 4
CHK2 97 8
GSK3 beta 38 2
CDK2-Cyclin A 91 1
PLK1 90 1
Aurora A 103 9
Aurora B 84 7
LKB1 80 0
AMPK 77 0
MARK1 89 1
MARK2 80 2
MARK3 94 5
MARK4 86 0
BRSK1 110 5
BRSK2 92 6
MELK 77 10
NUAK1 92 7
CK1 delta 90 2
CK2 30 3
DYRK1A 21 8
DYRK2 7 0
DYRK3 15 1
NEK2a 94 5
NEK6 98 10
IKK beta 94 0
IKK epsilon 89 0
TBK1 87 2
PIM1 70 7
PIM2 85 11
PIM3 79 0
SRPK1 99 7
EF2K 100 12
HIPK1 104 5
HIPK2 64 5
HIPK3 96 3
CLK2 80 3
PAK2 93 1
PAK4 89 11
PAK5 81 2
PAK6 89 2
MST2 98 4
MST4 93 2
GCK 78 5
MINK1 84 5
MEKK1 99 4
MLK1 95 10
MLK3 81 5
TAO1 82 2
ASK1 104 1
TAK1 82 5
IRAK4 88 6
RIPK2 94 6
TTK 79 1
Src 85 2
Lck 113 7
CSK 86 12
YES1 91 10
BTK 95 8
JAK2 97 4
SYK 107 5
EPH-A2 94 8
EPH-A4 103 5
EPH-B1 95 10
EPH-B2 106 6
EPH-B3 93 3
EPH-B4 97 0
FGF-R1 105 0
HER4 88 11
IGF-1R 107 15
IR 111 10
IRR 79 0
TrkA 83 6
VEGFR1 84 14
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 78 7
MKK2 75 2
MKK6 99 9
ERK1 78 1
ERK2 96 15
JNK1 77 9
JNK2 85 3
JNK3 72 6
p38 alpha MAPK 98 11
p38 beta MAPK 104 6
p38 gamma MAPK 65 7
p38 delta MAPK 54 6
ERK8 2 0
RSK1 33 7
RSK2 44 5
PDK1 91 12
PKB alpha 78 1
PKB beta 62 2
SGK1 68 2
S6K1 64 13
PKA 72 1
ROCK 2 38 0
PRK2 53 15
PKC alpha 30 1
PKC zeta 67 5
PKD1 80 6
MSK1 20 1
MNK1 84 6
MNK2 58 6
MAPKAP-K2 85 1
MAPKAP-K3 87 0
PRAK 56 1
CAMKK beta 23 2
CAMK1 85 6
SmMLCK 35 5
PHK 84 1
DAPK1 18 2
CHK1 87 2
CHK2 59 0
GSK3 beta 10 2
CDK2-Cyclin A 105 2
PLK1 24 3
Aurora A 78 1
Aurora B 58 2
LKB1 59 4
AMPK 49 4
MARK1 78 1
MARK2 83 7
MARK3 71 6
MARK4 78 3
BRSK1 90 8
BRSK2 95 3
MELK 62 1
NUAK1 78 1
CK1 delta 59 5
CK2 6 1
DYRK1A 3 1
DYRK2 2 0
DYRK3 6 2
NEK2a 80 9
NEK6 94 6
IKK beta 64 1
IKK epsilon 69 2
TBK1 63 11
PIM1 18 5
PIM2 14 0
PIM3 21 4
SRPK1 48 6
EF2K 101 9
HIPK1 9 2
HIPK2 10 10
HIPK3 10 0
CLK2 12 1
PAK2 90 7
PAK4 54 3
PAK5 66 6
PAK6 87 3
MST2 75 0
MST4 61 6
GCK 13 1
MINK1 21 2
MEKK1 51 7
MLK1 42 1
MLK3 25 0
TAO1 36 0
ASK1 112 1
TAK1 75 11
IRAK4 74 2
RIPK2 22 1
TTK 51 5
Src 92 2
Lck 99 8
CSK 100 4
YES1 87 1
BTK 71 7
JAK2 74 0
SYK 95 3
EPH-A2 89 4
EPH-A4 112 9
EPH-B1 107 6
EPH-B2 99 8
EPH-B3 96 12
EPH-B4 96 3
FGF-R1 61 6
HER4 73 4
IGF-1R 95 11
IR 108 4
IRR 26 6
TrkA 89 6
VEGFR1 24 6

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