Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MLN120B C19H17Cl3N4O2 439.72 IKKb Nagashima K. Fraser C.C. (2006) Blood 107 4266-4273 Catley M.C. Newton R. (2006) Mol.Pharmacol. 70 697-705 Download

Results as Barchart

View results as a bar chart
10µM
30µM

Results as Table

Screening Concentration: 30µM
Kinase % Activity Remaining Standard Deviation
MKK1 61 0
MKK2 74 0
MKK6 84 14
ERK1 73 1
ERK2 95 9
JNK1 77 2
JNK2 85 8
JNK3 65 1
p38 alpha MAPK 82 1
p38 beta MAPK 83 4
p38 gamma MAPK 44 5
p38 delta MAPK 62 2
ERK8 15 0
RSK1 73 4
RSK2 53 1
PDK1 79 1
PKB alpha 60 1
PKB beta 60 1
SGK1 80 1
S6K1 72 4
PKA 81 4
ROCK 2 26 3
PRK2 30 2
PKC alpha 75 1
PKC zeta 85 8
PKD1 49 0
MSK1 78 0
MNK1 47 5
MNK2 47 6
MAPKAP-K2 78 1
MAPKAP-K3 70 5
PRAK 78 5
CAMKK beta 40 3
CAMK1 22 1
SmMLCK 38 7
PHK 58 1
DAPK1 16 2
CHK1 69 10
CHK2 71 2
GSK3 beta 53 7
CDK2-Cyclin A 52 0
PLK1 73 2
Aurora A 32 3
Aurora B 25 4
LKB1 51 4
AMPK 74 0
MARK1 64 0
MARK2 63 3
MARK3 66 10
MARK4 88 8
BRSK1 35 0
BRSK2 42 3
MELK 33 10
NUAK1 29 2
CK1 delta 74 7
CK2 106 3
DYRK1A 16 1
DYRK2 26 3
DYRK3 27 3
NEK2a 76 8
NEK6 94 14
IKK beta 11 0
IKK epsilon 53 2
TBK1 69 7
PIM1 13 1
PIM2 39 3
PIM3 17 1
SRPK1 86 3
EF2K 119 1
HIPK1 82 3
HIPK2 49 4
HIPK3 98 2
CLK2 15 6
PAK2 79 2
PAK4 69 1
PAK5 64 3
PAK6 92 3
MST2 54 1
MST4 125 10
GCK 26 0
MINK1 26 2
MEKK1 74 6
MLK1 54 5
MLK3 31 1
TAO1 54 3
ASK1 99 5
TAK1 67 7
IRAK4 41 5
RIPK2 24 6
TTK 45 3
Src 75 5
Lck 72 5
CSK 85 10
YES1 39 1
BTK 37 10
JAK2 46 6
SYK 62 8
EPH-A2 71 5
EPH-A4 84 10
EPH-B1 88 3
EPH-B2 76 10
EPH-B3 47 6
EPH-B4 89 1
FGF-R1 41 4
HER4 42 11
IGF-1R 54 8
IR 84 12
IRR 38 3
TrkA 51 2
VEGFR1 20 3
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 12
MKK2 96 2
MKK6 94 4
ERK1 111 2
ERK2 105 5
JNK1 92 5
JNK2 99 1
JNK3 95 1
p38 alpha MAPK 101 1
p38 beta MAPK 100 7
p38 gamma MAPK 94 6
p38 delta MAPK 90 5
ERK8 80 4
RSK1 95 8
RSK2 99 2
PDK1 81 7
PKB alpha 105 9
PKB beta 82 7
SGK1 98 1
S6K1 95 10
PKA 93 12
ROCK 2 76 5
PRK2 63 0
PKC alpha 99 1
PKC zeta 107 5
PKD1 104 5
MSK1 104 2
MNK1 70 2
MNK2 92 4
MAPKAP-K2 95 1
MAPKAP-K3 95 2
PRAK 98 1
CAMKK beta 76 3
CAMK1 80 3
SmMLCK 64 7
PHK 105 1
DAPK1 37 2
CHK1 90 2
CHK2 107 9
GSK3 beta 89 7
CDK2-Cyclin A 112 2
PLK1 99 3
Aurora A 81 0
Aurora B 72 1
LKB1 92 2
AMPK 92 4
MARK1 107 2
MARK2 85 1
MARK3 96 4
MARK4 95 4
BRSK1 86 5
BRSK2 81 5
MELK 81 1
NUAK1 74 14
CK1 delta 95 1
CK2 118 4
DYRK1A 70 4
DYRK2 80 4
DYRK3 83 6
NEK2a 90 10
NEK6 94 5
IKK beta 44 1
IKK epsilon 90 0
TBK1 96 1
PIM1 48 2
PIM2 80 5
PIM3 40 6
SRPK1 101 10
EF2K 103 1
HIPK1 109 11
HIPK2 71 5
HIPK3 104 2
CLK2 54 1
PAK2 96 3
PAK4 94 3
PAK5 99 2
PAK6 90 4
MST2 91 1
MST4 115 3
GCK 87 1
MINK1 97 1
MEKK1 95 5
MLK1 77 2
MLK3 80 5
TAO1 104 1
ASK1 104 4
TAK1 88 4
IRAK4 80 7
RIPK2 42 7
TTK 80 3
Src 102 3
Lck 88 5
CSK 109 4
YES1 82 6
BTK 70 2
JAK2 93 9
SYK 95 7
EPH-A2 92 4
EPH-A4 105 10
EPH-B1 102 4
EPH-B2 101 4
EPH-B3 92 13
EPH-B4 105 11
FGF-R1 100 7
HER4 65 1
IGF-1R 97 13
IR 108 8
IRR 66 7
TrkA 73 14
VEGFR1 74 7

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