Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IPA-3 C20H14O2S2 350.45 PAK1 Deacon S.W. (2008) Chemistry and Biology 15 322 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
5µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
RSK1 184 133
CK1 delta 130 25
CK2 127 3
PAK5 121 2
p38 beta MAPK 117 12
IR 113 6
PHK 108 2
SGK1 107 5
GSK3 beta 106 8
p38 delta MAPK 104 5
p38 gamma MAPK 103 12
PRAK 102 6
ERK2 101 5
MSK1 101 5
PAK6 101 4
MNK1 100 5
PKA 100 0
CSK 99 7
PAK4 98 9
EPH-A2 97 4
MELK 97 2
MKK1 96 0
JNK2 94 17
CHK2 94 8
SYK 92 0
AMPK 90 7
CAMKK beta 90 0
Lck 90 5
JNK1 89 5
EF2K 89 8
Src 89 0
CDK2-Cyclin A 88 0
CHK1 88 0
PRK2 87 6
MNK2 87 11
SmMLCK 87 1
PDK1 86 14
PKB alpha 85 0
SRPK1 84 12
IGF-1R 84 1
IRR 83 0
p38 alpha MAPK 83 8
DYRK1A 83 3
PIM2 81 7
ROCK 2 78 5
TBK1 77 2
MAPKAP-K2 76 0
DYRK3 74 1
HIPK2 73 4
IKK epsilon 70 1
MARK3 69 2
IKK beta 68 3
NEK6 65 18
PKC alpha 65 2
DYRK2 64 9
YES1 60 3
PIM3 58 3
NEK2a 54 12
MST4 53 3
MST2 51 0
ERK8 49 3
BRSK2 48 4
VEGFR1 47 0
PIM1 46 0
PKC zeta 39 5
FGF-R1 29 1
PKD1 28 4
BTK 27 2
EPH-B3 26 1
PLK1 9 3
ERK1 8 5
CAMK1 7 2
RSK2 6 2
Aurora B 5 0
S6K1 3 0
PKB beta 0 0
Screening Concentration: 5µM
Kinase % Activity Remainingsort ascending Standard Deviation
EPH-B2 169 8
ASK1 154 10
EPH-B4 119 8
RIPK2 114 10
p38 beta MAPK 112 13
CSK 109 2
CDK2-Cyclin A 106 1
PHK 103 6
EPH-B1 102 10
TAO1 102 3
p38 delta MAPK 102 15
p38 gamma MAPK 99 4
Lck 99 1
CK2 97 4
CK1 delta 94 5
IGF-1R 94 10
IR 93 7
PKA 92 2
EPH-A4 89 5
CHK1 88 8
ROCK 2 87 3
DAPK1 83 8
JNK2 80 7
MNK2 78 10
JNK3 77 8
JNK1 76 1
MNK1 76 12
PDK1 75 13
EPH-A2 75 7
MKK6 70 3
EPH-B3 69 6
MAPKAP-K2 69 1
p38 alpha MAPK 68 13
MARK2 66 10
MSK1 65 0
MARK3 63 1
RSK1 62 6
PKB alpha 62 7
EF2K 60 8
SmMLCK 51 5
HER4 49 6
PAK5 49 14
CAMKK beta 49 7
HIPK1 48 1
PKC alpha 48 12
CLK2 48 4
MKK2 48 6
SGK1 48 0
SRPK1 47 4
IRR 47 1
PRAK 46 12
DYRK2 45 1
PAK4 45 6
PAK6 45 6
MARK4 41 3
TTK 40 5
ERK2 39 5
MARK1 38 5
MEKK1 38 3
CHK2 34 6
YES1 34 2
JAK2 34 1
HIPK3 33 10
DYRK3 33 4
PRK2 30 2
GSK3 beta 30 3
AMPK 27 4
BRSK1 24 5
TBK1 22 5
PIM2 21 5
DYRK1A 19 4
TrkA 19 2
BTK 19 2
MKK1 18 1
Src 17 1
LKB1 17 1
PIM3 17 1
HIPK2 15 1
TAK1 15 7
PIM1 15 3
S6K1 14 3
BRSK2 14 6
MELK 14 5
PLK1 12 2
SYK 12 1
PKC zeta 11 6
NEK6 11 0
PKD1 10 1
MAPKAP-K3 10 1
IRAK4 9 1
NEK2a 8 1
MST4 8 8
ERK1 6 2
NUAK1 6 2
IKK beta 6 2
MST2 6 0
RSK2 6 1
FGF-R1 4 1
IKK epsilon 4 1
VEGFR1 4 1
MLK1 4 1
CAMK1 3 0
MLK3 2 0
PAK2 2 0
Aurora A 2 0
Aurora B 2 1
GCK 2 0
ERK8 1 0
MINK1 1 1
PKB beta 0 0
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
EPH-B2 137 5
ASK1 129 8
PAK4 119 2
EPH-B1 118 13
RIPK2 117 10
p38 beta MAPK 114 13
IR 110 6
EPH-B4 109 7
JNK3 106 4
PDK1 106 6
CK2 104 6
TAO1 103 1
p38 delta MAPK 102 4
CSK 102 1
PKA 101 1
DAPK1 101 9
CDK2-Cyclin A 101 4
PHK 100 0
JNK1 99 8
PAK5 99 6
Lck 99 2
CAMKK beta 98 13
EPH-A4 98 4
p38 gamma MAPK 97 3
MNK2 97 3
CK1 delta 96 4
ROCK 2 95 0
JNK2 94 8
MKK6 93 3
PKC alpha 91 5
EPH-A2 91 11
PLK1 90 14
MAPKAP-K2 90 7
MKK2 90 9
CHK1 89 6
SGK1 89 7
MNK1 88 2
IGF-1R 87 1
PKB alpha 87 7
EPH-B3 86 12
PAK6 86 4
PRAK 86 1
MARK2 85 5
MKK1 85 1
IRR 84 2
EF2K 83 3
MARK3 81 4
p38 alpha MAPK 80 5
MSK1 79 5
RSK1 78 11
CLK2 77 0
SYK 77 4
PIM3 76 0
SmMLCK 74 10
PRK2 72 7
JAK2 72 12
GSK3 beta 68 0
DYRK2 68 6
TTK 68 2
MARK1 65 5
PIM2 65 2
MEKK1 64 5
TrkA 63 5
HER4 62 7
SRPK1 62 2
LKB1 60 8
YES1 59 2
TBK1 59 5
CHK2 58 2
ERK2 56 4
S6K1 56 0
AMPK 55 1
DYRK3 54 9
HIPK1 52 3
TAK1 47 9
IRAK4 47 1
DYRK1A 47 1
MARK4 47 7
PKC zeta 44 6
Src 42 7
BRSK2 39 0
HIPK3 37 2
PIM1 37 1
NEK6 34 6
IKK beta 33 3
GCK 30 6
BRSK1 29 2
BTK 28 5
MAPKAP-K3 26 4
HIPK2 24 1
PKD1 24 1
FGF-R1 24 0
MLK1 16 2
MELK 13 7
RSK2 12 1
NUAK1 11 1
NEK2a 10 3
ERK1 9 0
MLK3 9 1
IKK epsilon 7 3
MST4 6 1
VEGFR1 6 1
CAMK1 6 0
PAK2 5 1
MST2 5 0
MINK1 3 1
Aurora A 2 0
Aurora B 2 0
ERK8 2 1
PKB beta 1 0

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