Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IPA-3 C20H14O2S2 350.45 PAK1 Deacon S.W. (2008) Chemistry and Biology 15 322 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
5µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PKB beta 0 0
S6K1 3 0
Aurora B 5 0
RSK2 6 2
CAMK1 7 2
ERK1 8 5
PLK1 9 3
EPH-B3 26 1
BTK 27 2
PKD1 28 4
FGF-R1 29 1
PKC zeta 39 5
PIM1 46 0
VEGFR1 47 0
BRSK2 48 4
ERK8 49 3
MST2 51 0
MST4 53 3
NEK2a 54 12
PIM3 58 3
YES1 60 3
DYRK2 64 9
NEK6 65 18
PKC alpha 65 2
IKK beta 68 3
MARK3 69 2
IKK epsilon 70 1
HIPK2 73 4
DYRK3 74 1
MAPKAP-K2 76 0
TBK1 77 2
ROCK 2 78 5
PIM2 81 7
DYRK1A 83 3
IRR 83 0
p38 alpha MAPK 83 8
SRPK1 84 12
IGF-1R 84 1
PKB alpha 85 0
PDK1 86 14
MNK2 87 11
SmMLCK 87 1
PRK2 87 6
CHK1 88 0
CDK2-Cyclin A 88 0
EF2K 89 8
Src 89 0
JNK1 89 5
CAMKK beta 90 0
Lck 90 5
AMPK 90 7
SYK 92 0
CHK2 94 8
JNK2 94 17
MKK1 96 0
MELK 97 2
EPH-A2 97 4
PAK4 98 9
CSK 99 7
PKA 100 0
MNK1 100 5
PAK6 101 4
ERK2 101 5
MSK1 101 5
PRAK 102 6
p38 gamma MAPK 103 12
p38 delta MAPK 104 5
GSK3 beta 106 8
SGK1 107 5
PHK 108 2
IR 113 6
p38 beta MAPK 117 12
PAK5 121 2
CK2 127 3
CK1 delta 130 25
RSK1 184 133
Screening Concentration: 5µM
Kinase % Activity Remainingsort descending Standard Deviation
PKB beta 0 0
ERK8 1 0
MINK1 1 1
Aurora A 2 0
Aurora B 2 1
GCK 2 0
MLK3 2 0
PAK2 2 0
CAMK1 3 0
IKK epsilon 4 1
VEGFR1 4 1
MLK1 4 1
FGF-R1 4 1
IKK beta 6 2
MST2 6 0
RSK2 6 1
ERK1 6 2
NUAK1 6 2
NEK2a 8 1
MST4 8 8
IRAK4 9 1
MAPKAP-K3 10 1
PKD1 10 1
NEK6 11 0
PKC zeta 11 6
SYK 12 1
PLK1 12 2
S6K1 14 3
BRSK2 14 6
MELK 14 5
PIM1 15 3
HIPK2 15 1
TAK1 15 7
Src 17 1
LKB1 17 1
PIM3 17 1
MKK1 18 1
TrkA 19 2
BTK 19 2
DYRK1A 19 4
PIM2 21 5
TBK1 22 5
BRSK1 24 5
AMPK 27 4
PRK2 30 2
GSK3 beta 30 3
DYRK3 33 4
HIPK3 33 10
YES1 34 2
JAK2 34 1
CHK2 34 6
MARK1 38 5
MEKK1 38 3
ERK2 39 5
TTK 40 5
MARK4 41 3
PAK4 45 6
PAK6 45 6
DYRK2 45 1
PRAK 46 12
IRR 47 1
SRPK1 47 4
MKK2 48 6
SGK1 48 0
HIPK1 48 1
PKC alpha 48 12
CLK2 48 4
PAK5 49 14
CAMKK beta 49 7
HER4 49 6
SmMLCK 51 5
EF2K 60 8
RSK1 62 6
PKB alpha 62 7
MARK3 63 1
MSK1 65 0
MARK2 66 10
p38 alpha MAPK 68 13
MAPKAP-K2 69 1
EPH-B3 69 6
MKK6 70 3
PDK1 75 13
EPH-A2 75 7
MNK1 76 12
JNK1 76 1
JNK3 77 8
MNK2 78 10
JNK2 80 7
DAPK1 83 8
ROCK 2 87 3
CHK1 88 8
EPH-A4 89 5
PKA 92 2
IR 93 7
CK1 delta 94 5
IGF-1R 94 10
CK2 97 4
p38 gamma MAPK 99 4
Lck 99 1
p38 delta MAPK 102 15
EPH-B1 102 10
TAO1 102 3
PHK 103 6
CDK2-Cyclin A 106 1
CSK 109 2
p38 beta MAPK 112 13
RIPK2 114 10
EPH-B4 119 8
ASK1 154 10
EPH-B2 169 8
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
PKB beta 1 0
Aurora B 2 0
ERK8 2 1
Aurora A 2 0
MINK1 3 1
MST2 5 0
PAK2 5 1
MST4 6 1
VEGFR1 6 1
CAMK1 6 0
IKK epsilon 7 3
MLK3 9 1
ERK1 9 0
NEK2a 10 3
NUAK1 11 1
RSK2 12 1
MELK 13 7
MLK1 16 2
HIPK2 24 1
PKD1 24 1
FGF-R1 24 0
MAPKAP-K3 26 4
BTK 28 5
BRSK1 29 2
GCK 30 6
IKK beta 33 3
NEK6 34 6
PIM1 37 1
HIPK3 37 2
BRSK2 39 0
Src 42 7
PKC zeta 44 6
MARK4 47 7
TAK1 47 9
IRAK4 47 1
DYRK1A 47 1
HIPK1 52 3
DYRK3 54 9
AMPK 55 1
S6K1 56 0
ERK2 56 4
CHK2 58 2
YES1 59 2
TBK1 59 5
LKB1 60 8
HER4 62 7
SRPK1 62 2
TrkA 63 5
MEKK1 64 5
MARK1 65 5
PIM2 65 2
GSK3 beta 68 0
DYRK2 68 6
TTK 68 2
JAK2 72 12
PRK2 72 7
SmMLCK 74 10
PIM3 76 0
SYK 77 4
CLK2 77 0
RSK1 78 11
MSK1 79 5
p38 alpha MAPK 80 5
MARK3 81 4
EF2K 83 3
IRR 84 2
MARK2 85 5
MKK1 85 1
PAK6 86 4
PRAK 86 1
EPH-B3 86 12
IGF-1R 87 1
PKB alpha 87 7
MNK1 88 2
SGK1 89 7
CHK1 89 6
MAPKAP-K2 90 7
MKK2 90 9
PLK1 90 14
EPH-A2 91 11
PKC alpha 91 5
MKK6 93 3
JNK2 94 8
ROCK 2 95 0
CK1 delta 96 4
p38 gamma MAPK 97 3
MNK2 97 3
CAMKK beta 98 13
EPH-A4 98 4
PAK5 99 6
Lck 99 2
JNK1 99 8
PHK 100 0
PKA 101 1
DAPK1 101 9
CDK2-Cyclin A 101 4
p38 delta MAPK 102 4
CSK 102 1
TAO1 103 1
CK2 104 6
PDK1 106 6
JNK3 106 4
EPH-B4 109 7
IR 110 6
p38 beta MAPK 114 13
RIPK2 117 10
EPH-B1 118 13
PAK4 119 2
ASK1 129 8
EPH-B2 137 5

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