Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IPA-3 C20H14O2S2 350.45 PAK1 Deacon S.W. (2008) Chemistry and Biology 15 322 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
5µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 1
MKK2 90 9
MKK6 93 3
ERK1 9 0
ERK2 56 4
JNK1 99 8
JNK2 94 8
JNK3 106 4
p38 alpha MAPK 80 5
p38 beta MAPK 114 13
p38 gamma MAPK 97 3
p38 delta MAPK 102 4
ERK8 2 1
RSK1 78 11
RSK2 12 1
PDK1 106 6
PKB alpha 87 7
PKB beta 1 0
SGK1 89 7
S6K1 56 0
PKA 101 1
ROCK 2 95 0
PRK2 72 7
PKC alpha 91 5
PKC zeta 44 6
PKD1 24 1
MSK1 79 5
MNK1 88 2
MNK2 97 3
MAPKAP-K2 90 7
MAPKAP-K3 26 4
PRAK 86 1
CAMKK beta 98 13
CAMK1 6 0
SmMLCK 74 10
PHK 100 0
DAPK1 101 9
CHK1 89 6
CHK2 58 2
GSK3 beta 68 0
CDK2-Cyclin A 101 4
PLK1 90 14
Aurora A 2 0
Aurora B 2 0
LKB1 60 8
AMPK 55 1
MARK1 65 5
MARK2 85 5
MARK3 81 4
MARK4 47 7
BRSK1 29 2
BRSK2 39 0
MELK 13 7
NUAK1 11 1
CK1 delta 96 4
CK2 104 6
DYRK1A 47 1
DYRK2 68 6
DYRK3 54 9
NEK2a 10 3
NEK6 34 6
IKK beta 33 3
IKK epsilon 7 3
TBK1 59 5
PIM1 37 1
PIM2 65 2
PIM3 76 0
SRPK1 62 2
EF2K 83 3
HIPK1 52 3
HIPK2 24 1
HIPK3 37 2
CLK2 77 0
PAK2 5 1
PAK4 119 2
PAK5 99 6
PAK6 86 4
MST2 5 0
MST4 6 1
GCK 30 6
MINK1 3 1
MEKK1 64 5
MLK1 16 2
MLK3 9 1
TAO1 103 1
ASK1 129 8
TAK1 47 9
IRAK4 47 1
RIPK2 117 10
TTK 68 2
Src 42 7
Lck 99 2
CSK 102 1
YES1 59 2
BTK 28 5
JAK2 72 12
SYK 77 4
EPH-A2 91 11
EPH-A4 98 4
EPH-B1 118 13
EPH-B2 137 5
EPH-B3 86 12
EPH-B4 109 7
FGF-R1 24 0
HER4 62 7
IGF-1R 87 1
IR 110 6
IRR 84 2
TrkA 63 5
VEGFR1 6 1
Screening Concentration: 5µM
Kinase % Activity Remaining Standard Deviation
MKK1 18 1
MKK2 48 6
MKK6 70 3
ERK1 6 2
ERK2 39 5
JNK1 76 1
JNK2 80 7
JNK3 77 8
p38 alpha MAPK 68 13
p38 beta MAPK 112 13
p38 gamma MAPK 99 4
p38 delta MAPK 102 15
ERK8 1 0
RSK1 62 6
RSK2 6 1
PDK1 75 13
PKB alpha 62 7
PKB beta 0 0
SGK1 48 0
S6K1 14 3
PKA 92 2
ROCK 2 87 3
PRK2 30 2
PKC alpha 48 12
PKC zeta 11 6
PKD1 10 1
MSK1 65 0
MNK1 76 12
MNK2 78 10
MAPKAP-K2 69 1
MAPKAP-K3 10 1
PRAK 46 12
CAMKK beta 49 7
CAMK1 3 0
SmMLCK 51 5
PHK 103 6
DAPK1 83 8
CHK1 88 8
CHK2 34 6
GSK3 beta 30 3
CDK2-Cyclin A 106 1
PLK1 12 2
Aurora A 2 0
Aurora B 2 1
LKB1 17 1
AMPK 27 4
MARK1 38 5
MARK2 66 10
MARK3 63 1
MARK4 41 3
BRSK1 24 5
BRSK2 14 6
MELK 14 5
NUAK1 6 2
CK1 delta 94 5
CK2 97 4
DYRK1A 19 4
DYRK2 45 1
DYRK3 33 4
NEK2a 8 1
NEK6 11 0
IKK beta 6 2
IKK epsilon 4 1
TBK1 22 5
PIM1 15 3
PIM2 21 5
PIM3 17 1
SRPK1 47 4
EF2K 60 8
HIPK1 48 1
HIPK2 15 1
HIPK3 33 10
CLK2 48 4
PAK2 2 0
PAK4 45 6
PAK5 49 14
PAK6 45 6
MST2 6 0
MST4 8 8
GCK 2 0
MINK1 1 1
MEKK1 38 3
MLK1 4 1
MLK3 2 0
TAO1 102 3
ASK1 154 10
TAK1 15 7
IRAK4 9 1
RIPK2 114 10
TTK 40 5
Src 17 1
Lck 99 1
CSK 109 2
YES1 34 2
BTK 19 2
JAK2 34 1
SYK 12 1
EPH-A2 75 7
EPH-A4 89 5
EPH-B1 102 10
EPH-B2 169 8
EPH-B3 69 6
EPH-B4 119 8
FGF-R1 4 1
HER4 49 6
IGF-1R 94 10
IR 93 7
IRR 47 1
TrkA 19 2
VEGFR1 4 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 0
ERK1 8 5
ERK2 101 5
JNK1 89 5
JNK2 94 17
p38 alpha MAPK 83 8
p38 beta MAPK 117 12
p38 gamma MAPK 103 12
p38 delta MAPK 104 5
ERK8 49 3
RSK1 184 133
RSK2 6 2
PDK1 86 14
PKB alpha 85 0
PKB beta 0 0
SGK1 107 5
S6K1 3 0
PKA 100 0
ROCK 2 78 5
PRK2 87 6
PKC alpha 65 2
PKC zeta 39 5
PKD1 28 4
MSK1 101 5
MNK1 100 5
MNK2 87 11
MAPKAP-K2 76 0
PRAK 102 6
CAMKK beta 90 0
CAMK1 7 2
SmMLCK 87 1
PHK 108 2
CHK1 88 0
CHK2 94 8
GSK3 beta 106 8
CDK2-Cyclin A 88 0
PLK1 9 3
Aurora B 5 0
AMPK 90 7
MARK3 69 2
BRSK2 48 4
MELK 97 2
CK1 delta 130 25
CK2 127 3
DYRK1A 83 3
DYRK2 64 9
DYRK3 74 1
NEK2a 54 12
NEK6 65 18
IKK beta 68 3
IKK epsilon 70 1
TBK1 77 2
PIM1 46 0
PIM2 81 7
PIM3 58 3
SRPK1 84 12
EF2K 89 8
HIPK2 73 4
PAK4 98 9
PAK5 121 2
PAK6 101 4
MST2 51 0
MST4 53 3
Src 89 0
Lck 90 5
CSK 99 7
YES1 60 3
BTK 27 2
SYK 92 0
EPH-A2 97 4
EPH-B3 26 1
FGF-R1 29 1
IGF-1R 84 1
IR 113 6
IRR 83 0
VEGFR1 47 0

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