Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BI-78D3 C13H9N5O5S2 379.37 JNK Stebbins J.L. (2008) PNAS 105 16809-16813 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
0.1µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PKB beta 1 0
NEK2a 1 0
Aurora B 2 0
BTK 2 0
PLK1 3 0
CAMK1 12 3
S6K1 18 0
RSK2 24 2
NEK6 24 2
IKK beta 27 2
MST4 34 4
VEGFR1 38 1
PKC alpha 49 2
EPH-B3 62 4
YES1 63 4
PKD1 63 2
PIM1 63 0
DYRK3 64 3
PKC zeta 65 2
RSK1 69 12
BRSK2 70 8
TBK1 73 9
DYRK2 76 3
PIM3 78 1
MELK 78 14
IKK epsilon 79 0
MST2 80 3
PRAK 80 4
CAMKK beta 80 1
MAPKAP-K2 82 9
Src 82 7
IRR 82 5
MARK3 83 5
EF2K 83 6
ERK1 83 5
GSK3 beta 84 4
CDK2-Cyclin A 84 8
MSK1 85 0
JNK2 87 0
CHK2 87 0
MNK2 90 0
MKK1 90 8
IGF-1R 91 1
AMPK 91 11
PAK6 91 0
SmMLCK 91 11
CSK 91 7
ROCK 2 91 2
Lck 93 2
p38 alpha MAPK 94 4
JNK1 95 1
PRK2 95 3
SYK 95 3
MNK1 96 0
DYRK1A 98 5
PKB alpha 98 10
ERK2 98 0
PKA 98 4
CHK1 100 3
PAK5 101 5
p38 delta MAPK 104 3
SRPK1 105 8
PHK 105 2
CK2 106 4
EPH-A2 110 16
p38 beta MAPK 110 2
p38 gamma MAPK 110 2
SGK1 116 17
FGF-R1 116 13
HIPK2 118 1
IR 119 9
CK1 delta 119 5
PAK4 120 1
PIM2 123 11
PDK1 125 7
ERK8 148 26
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
BTK 23 4
NEK2a 25 6
Aurora B 38 4
VEGFR1 38 1
PKB beta 46 5
HER4 46 13
CAMK1 50 2
MLK1 51 0
RSK2 53 5
Src 55 8
PIM1 68 2
MINK1 68 6
BRSK2 71 2
Aurora A 71 3
AMPK 71 3
MARK2 72 8
MARK4 72 1
PLK1 73 1
MAPKAP-K3 73 5
IKK epsilon 73 1
EPH-A2 74 9
LKB1 74 7
PAK6 74 4
TBK1 75 1
DAPK1 75 5
DYRK2 75 3
p38 delta MAPK 75 0
RSK1 76 11
PKD1 77 5
TrkA 77 8
YES1 78 8
PAK5 79 7
MKK2 80 11
MST2 80 3
IRAK4 81 9
p38 alpha MAPK 81 7
MSK1 82 2
IRR 82 5
IKK beta 82 0
MST4 82 5
CAMKK beta 83 11
GCK 84 3
MKK1 84 15
MARK3 84 2
CDK2-Cyclin A 84 7
TTK 84 6
SRPK1 85 5
TAO1 85 2
NUAK1 85 14
CSK 85 2
BRSK1 86 11
MELK 86 5
HIPK1 86 10
PRK2 86 6
PRAK 87 1
GSK3 beta 87 4
p38 gamma MAPK 87 5
ROCK 2 88 1
FGF-R1 88 4
MLK3 89 6
EF2K 89 6
p38 beta MAPK 89 2
DYRK3 89 10
PDK1 90 4
MKK6 90 1
TAK1 90 2
PAK2 90 8
PAK4 90 10
EPH-B3 91 8
EPH-B4 91 2
PKB alpha 92 1
SmMLCK 92 9
S6K1 92 4
CHK1 92 10
CLK2 92 2
RIPK2 92 12
SGK1 93 2
PIM3 93 8
JNK1 93 2
HIPK3 93 4
Lck 93 2
NEK6 93 2
JAK2 94 4
ERK2 94 14
MAPKAP-K2 94 9
MARK1 94 0
PKA 95 3
ASK1 95 3
JNK3 95 3
MNK2 95 3
MEKK1 96 3
JNK2 97 3
CHK2 97 8
DYRK1A 97 1
PKC alpha 98 5
MNK1 98 10
EPH-B1 99 5
PIM2 100 14
HIPK2 100 4
CK1 delta 101 4
EPH-A4 102 4
IR 102 1
SYK 103 13
PKC zeta 103 3
PHK 107 1
IGF-1R 107 7
CK2 108 2
ERK8 113 3
EPH-B2 119 2
ERK1 123 8
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
MLK1 59 1
BTK 71 4
NEK2a 74 5
VEGFR1 77 9
HER4 78 4
PAK6 79 5
CAMK1 80 4
NUAK1 80 4
PAK5 81 5
TBK1 82 2
CDK2-Cyclin A 82 5
Aurora B 82 1
AMPK 83 8
IR 83 12
CAMKK beta 84 7
p38 gamma MAPK 85 9
LKB1 85 3
MARK4 86 1
HIPK1 86 10
DYRK2 86 1
MARK2 87 4
MARK1 88 8
EPH-A2 88 15
SmMLCK 88 8
IGF-1R 88 13
Aurora A 88 0
RSK2 89 2
MAPKAP-K3 89 2
JAK2 89 14
PIM1 89 5
PKD1 89 3
PKB beta 90 8
BRSK2 90 5
MLK3 90 2
MSK1 90 1
RSK1 91 2
EPH-B3 91 12
HIPK3 91 4
FGF-R1 91 3
PLK1 91 1
YES1 92 1
SYK 92 7
JNK1 92 6
PRK2 92 9
IRAK4 92 1
TTK 92 10
MAPKAP-K2 93 4
IKK epsilon 93 4
TAK1 93 6
GSK3 beta 93 1
RIPK2 93 0
p38 delta MAPK 93 1
PRAK 94 0
MINK1 94 10
MKK2 95 1
ROCK 2 95 6
ERK2 96 7
CLK2 96 6
IKK beta 97 5
MST2 97 7
PDK1 97 4
GCK 97 9
SRPK1 97 0
EPH-B1 97 6
HIPK2 97 8
EPH-B4 97 2
p38 alpha MAPK 97 8
MARK3 98 6
PKA 98 3
PKC alpha 98 0
IRR 98 12
PKB alpha 99 1
PIM2 99 6
BRSK1 99 11
EPH-A4 99 9
CK1 delta 99 2
p38 beta MAPK 99 0
TAO1 100 9
ASK1 100 4
MNK2 100 2
MKK1 101 12
S6K1 101 7
DAPK1 101 1
CSK 101 11
SGK1 102 0
CHK1 102 14
PAK4 102 10
MKK6 103 6
EPH-B2 103 6
TrkA 103 7
MST4 105 8
JNK2 105 3
DYRK1A 105 5
DYRK3 105 1
ERK8 105 2
ERK1 106 4
PAK2 106 6
MNK1 106 15
PKC zeta 107 8
Lck 107 4
JNK3 108 13
EF2K 109 12
CHK2 109 3
NEK6 111 14
PIM3 115 5
PHK 117 4
CK2 118 4
MEKK1 120 0
MELK 121 7
Src 122 4

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