Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BI-78D3 C13H9N5O5S2 379.37 JNK Stebbins J.L. (2008) PNAS 105 16809-16813 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 84 15
MKK2 80 11
MKK6 90 1
ERK1 123 8
ERK2 94 14
JNK1 93 2
JNK2 97 3
JNK3 95 3
p38 alpha MAPK 81 7
p38 beta MAPK 89 2
p38 gamma MAPK 87 5
p38 delta MAPK 75 0
ERK8 113 3
RSK1 76 11
RSK2 53 5
PDK1 90 4
PKB alpha 92 1
PKB beta 46 5
SGK1 93 2
S6K1 92 4
PKA 95 3
ROCK 2 88 1
PRK2 86 6
PKC alpha 98 5
PKC zeta 103 3
PKD1 77 5
MSK1 82 2
MNK1 98 10
MNK2 95 3
MAPKAP-K2 94 9
MAPKAP-K3 73 5
PRAK 87 1
CAMKK beta 83 11
CAMK1 50 2
SmMLCK 92 9
PHK 107 1
DAPK1 75 5
CHK1 92 10
CHK2 97 8
GSK3 beta 87 4
CDK2-Cyclin A 84 7
PLK1 73 1
Aurora A 71 3
Aurora B 38 4
LKB1 74 7
AMPK 71 3
MARK1 94 0
MARK2 72 8
MARK3 84 2
MARK4 72 1
BRSK1 86 11
BRSK2 71 2
MELK 86 5
NUAK1 85 14
CK1 delta 101 4
CK2 108 2
DYRK1A 97 1
DYRK2 75 3
DYRK3 89 10
NEK2a 25 6
NEK6 93 2
IKK beta 82 0
IKK epsilon 73 1
TBK1 75 1
PIM1 68 2
PIM2 100 14
PIM3 93 8
SRPK1 85 5
EF2K 89 6
HIPK1 86 10
HIPK2 100 4
HIPK3 93 4
CLK2 92 2
PAK2 90 8
PAK4 90 10
PAK5 79 7
PAK6 74 4
MST2 80 3
MST4 82 5
GCK 84 3
MINK1 68 6
MEKK1 96 3
MLK1 51 0
MLK3 89 6
TAO1 85 2
ASK1 95 3
TAK1 90 2
IRAK4 81 9
RIPK2 92 12
TTK 84 6
Src 55 8
Lck 93 2
CSK 85 2
YES1 78 8
BTK 23 4
JAK2 94 4
SYK 103 13
EPH-A2 74 9
EPH-A4 102 4
EPH-B1 99 5
EPH-B2 119 2
EPH-B3 91 8
EPH-B4 91 2
FGF-R1 88 4
HER4 46 13
IGF-1R 107 7
IR 102 1
IRR 82 5
TrkA 77 8
VEGFR1 38 1
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 101 12
MKK2 95 1
MKK6 103 6
ERK1 106 4
ERK2 96 7
JNK1 92 6
JNK2 105 3
JNK3 108 13
p38 alpha MAPK 97 8
p38 beta MAPK 99 0
p38 gamma MAPK 85 9
p38 delta MAPK 93 1
ERK8 105 2
RSK1 91 2
RSK2 89 2
PDK1 97 4
PKB alpha 99 1
PKB beta 90 8
SGK1 102 0
S6K1 101 7
PKA 98 3
ROCK 2 95 6
PRK2 92 9
PKC alpha 98 0
PKC zeta 107 8
PKD1 89 3
MSK1 90 1
MNK1 106 15
MNK2 100 2
MAPKAP-K2 93 4
MAPKAP-K3 89 2
PRAK 94 0
CAMKK beta 84 7
CAMK1 80 4
SmMLCK 88 8
PHK 117 4
DAPK1 101 1
CHK1 102 14
CHK2 109 3
GSK3 beta 93 1
CDK2-Cyclin A 82 5
PLK1 91 1
Aurora A 88 0
Aurora B 82 1
LKB1 85 3
AMPK 83 8
MARK1 88 8
MARK2 87 4
MARK3 98 6
MARK4 86 1
BRSK1 99 11
BRSK2 90 5
MELK 121 7
NUAK1 80 4
CK1 delta 99 2
CK2 118 4
DYRK1A 105 5
DYRK2 86 1
DYRK3 105 1
NEK2a 74 5
NEK6 111 14
IKK beta 97 5
IKK epsilon 93 4
TBK1 82 2
PIM1 89 5
PIM2 99 6
PIM3 115 5
SRPK1 97 0
EF2K 109 12
HIPK1 86 10
HIPK2 97 8
HIPK3 91 4
CLK2 96 6
PAK2 106 6
PAK4 102 10
PAK5 81 5
PAK6 79 5
MST2 97 7
MST4 105 8
GCK 97 9
MINK1 94 10
MEKK1 120 0
MLK1 59 1
MLK3 90 2
TAO1 100 9
ASK1 100 4
TAK1 93 6
IRAK4 92 1
RIPK2 93 0
TTK 92 10
Src 122 4
Lck 107 4
CSK 101 11
YES1 92 1
BTK 71 4
JAK2 89 14
SYK 92 7
EPH-A2 88 15
EPH-A4 99 9
EPH-B1 97 6
EPH-B2 103 6
EPH-B3 91 12
EPH-B4 97 2
FGF-R1 91 3
HER4 78 4
IGF-1R 88 13
IR 83 12
IRR 98 12
TrkA 103 7
VEGFR1 77 9
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 90 8
ERK1 83 5
ERK2 98 0
JNK1 95 1
JNK2 87 0
p38 alpha MAPK 94 4
p38 beta MAPK 110 2
p38 gamma MAPK 110 2
p38 delta MAPK 104 3
ERK8 148 26
RSK1 69 12
RSK2 24 2
PDK1 125 7
PKB alpha 98 10
PKB beta 1 0
SGK1 116 17
S6K1 18 0
PKA 98 4
ROCK 2 91 2
PRK2 95 3
PKC alpha 49 2
PKC zeta 65 2
PKD1 63 2
MSK1 85 0
MNK1 96 0
MNK2 90 0
MAPKAP-K2 82 9
PRAK 80 4
CAMKK beta 80 1
CAMK1 12 3
SmMLCK 91 11
PHK 105 2
CHK1 100 3
CHK2 87 0
GSK3 beta 84 4
CDK2-Cyclin A 84 8
PLK1 3 0
Aurora B 2 0
AMPK 91 11
MARK3 83 5
BRSK2 70 8
MELK 78 14
CK1 delta 119 5
CK2 106 4
DYRK1A 98 5
DYRK2 76 3
DYRK3 64 3
NEK2a 1 0
NEK6 24 2
IKK beta 27 2
IKK epsilon 79 0
TBK1 73 9
PIM1 63 0
PIM2 123 11
PIM3 78 1
SRPK1 105 8
EF2K 83 6
HIPK2 118 1
PAK4 120 1
PAK5 101 5
PAK6 91 0
MST2 80 3
MST4 34 4
Src 82 7
Lck 93 2
CSK 91 7
YES1 63 4
BTK 2 0
SYK 95 3
EPH-A2 110 16
EPH-B3 62 4
FGF-R1 116 13
IGF-1R 91 1
IR 119 9
IRR 82 5
VEGFR1 38 1

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