Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
ZM 336372 C23H23N3O3 389.4 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 77 29
ERK2 92 1
JNK1 92 2
JNK3 83 6
p38 alpha MAPK 28 1
p38 beta MAPK 53 15
p38 gamma MAPK 86 2
p38 delta MAPK 92 9
ERK8 100 6
RSK1 102 15
RSK2 106 3
PDK1 95 3
PKB alpha 105 2
PKB beta 100 13
SGK1 90 5
S6K1 86 1
PKA 87 3
ROCK 2 85 1
PRK2 87 16
PKC alpha 95 5
PKD1 81 7
MSK1 96 2
MNK1 84 10
MNK2 95 2
MAPKAP-K2 89 1
MAPKAP-K3 91 0
PRAK 91 4
CAMK1 99 2
SmMLCK 91 5
PHK 96 11
CHK1 84 9
CHK2 83 6
GSK3 beta 85 12
CDK2-Cyclin A 96 3
PLK1 97 1
Aurora B 87 0
AMPK 89 0
MARK3 100 13
CK1 delta 90 2
CK2 100 7
DYRK1A 97 7
NEK2a 76 0
NEK6 105 3
NEK7 95 8
IKK beta 82 5
PIM2 74 10
SRPK1 94 9
EF2K 89 1
MST2 86 3
Src 95 5
Lck 28 0
CSK 95 25
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 105 0
ERK1 81 1
ERK2 93 2
JNK1 85 2
JNK2 84 6
JNK3 85 0
p38 alpha MAPK 7 0
p38 beta MAPK 14 1
p38 gamma MAPK 94 0
p38 delta MAPK 94 8
ERK8 87 1
RSK1 70 0
RSK2 69 4
PDK1 84 2
PKB alpha 104 1
PKB beta 62 1
SGK1 91 2
S6K1 110 3
PKA 92 6
ROCK 2 95 2
PRK2 91 5
PKC alpha 88 4
PKC zeta 77 7
PKD1 104 2
MSK1 95 1
MNK1 85 0
MNK2 101 8
MAPKAP-K2 89 6
MAPKAP-K3 105 8
PRAK 61 7
CAMKK alpha 101 2
CAMKK beta 96 1
CAMK1 77 9
SmMLCK 84 7
PHK 120 4
CHK1 89 8
CHK2 80 4
GSK3 beta 107 4
CDK2-Cyclin A 101 3
PLK1 95 3
Aurora B 94 2
Aurora C 85 5
AMPK 82 2
MARK3 121 8
BRSK2 78 9
MELK 82 8
CK1 delta 90 3
CK2 92 3
DYRK1A 75 6
DYRK2 92 1
DYRK3 90 1
NEK2a 85 6
NEK6 90 4
NEK7 97 0
IKK beta 90 7
IKK epsilon 97 6
TBK1 94 5
PIM1 95 6
PIM2 92 7
PIM3 80 3
SRPK1 86 3
EF2K 105 0
HIPK2 105 8
HIPK3 107 7
PAK4 97 3
PAK5 96 1
PAK6 107 1
MST2 84 1
MST4 103 11
Src 84 4
Lck 10 0
CSK 67 3
YES1 77 6
BTK 93 13
SYK 127 36
EPH-A2 13 3
EPH-B3 9 0
FGF-R1 105 6
IGF-1R 86 5
IR 94 8
IRR 88 1
VEGFR1 108 8

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