Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Wyeth PDK1 Inhibitor Compound 1 C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549 Download

Results as Barchart

View results as a bar chart
10µM
0.1µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 6 4
ERK1 48 1
ERK2 49 7
JNK1 80 19
JNK2 86 1
p38 alpha MAPK 108 7
p38 beta MAPK 84 15
p38 gamma MAPK 86 3
p38 delta MAPK 87 8
ERK8 18 1
RSK1 3 0
RSK2 4 0
PDK1 3 1
PKB alpha 93 5
PKB beta 88 5
SGK1 58 3
S6K1 34 0
PKA 53 8
ROCK 2 14 2
PRK2 16 1
PKC alpha 23 1
PKC zeta 37 2
PKD1 2 2
MSK1 59 8
MNK1 99 12
MNK2 93 2
MAPKAP-K2 105 55
PRAK 36 0
CAMKK beta 71 4
CAMK1 17 5
SmMLCK 33 5
PHK 13 0
CHK1 2 1
CHK2 13 2
GSK3 beta 24 0
CDK2-Cyclin A 58 3
PLK1 26 5
AMPK 25 21
MARK3 5 0
BRSK2 74 5
MELK 34 13
CK1 delta 46 2
CK2 80 2
DYRK1A 55 5
DYRK2 51 5
DYRK3 53 3
NEK2a 6 1
NEK6 79 8
IKK beta 50 1
IKK epsilon 6 0
TBK1 18 2
PIM1 36 12
PIM2 88 4
PIM3 21 1
SRPK1 82 0
EF2K 103 7
HIPK2 41 0
PAK4 21 0
PAK5 25 1
PAK6 54 2
MST2 1 0
MST4 35 7
Src 70 0
Lck 24 2
CSK 78 5
YES1 64 9
BTK 49 1
SYK 37 2
EPH-A2 70 1
EPH-B3 34 0
FGF-R1 30 0
IGF-1R 38 7
IR 53 2
IRR 36 4
VEGFR1 20 12
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 2 3
MKK2 16 3
MKK6 100 1
ERK1 31 2
ERK2 58 7
JNK1 80 8
JNK2 94 8
JNK3 63 4
p38 alpha MAPK 116 7
p38 beta MAPK 90 1
p38 gamma MAPK 109 8
p38 delta MAPK 84 13
ERK8 48 1
RSK1 2 1
RSK2 9 0
PDK1 14 1
PKB alpha 84 0
PKB beta 64 2
SGK1 86 2
S6K1 57 6
PKA 77 1
ROCK 2 15 4
PRK2 34 3
PKC alpha 62 5
PKC zeta 115 4
PKD1 10 1
MSK1 71 5
MNK1 90 3
MNK2 115 2
MAPKAP-K2 97 0
MAPKAP-K3 79 3
PRAK 82 8
CAMKK beta 91 2
CAMK1 82 3
SmMLCK 56 2
PHK 26 1
DAPK1 59 8
CHK1 20 1
CHK2 7 2
GSK3 beta 32 2
CDK2-Cyclin A 69 8
PLK1 45 2
Aurora A 82 3
Aurora B 68 6
LKB1 84 11
AMPK 20 3
MARK1 34 2
MARK2 72 9
MARK3 18 3
MARK4 40 7
BRSK1 67 6
BRSK2 77 6
MELK 61 3
NUAK1 25 7
CK1 delta 70 5
CK2 75 1
DYRK1A 55 2
DYRK2 78 1
DYRK3 71 2
NEK2a 18 3
NEK6 95 3
IKK beta 31 0
IKK epsilon 9 1
TBK1 17 7
PIM1 69 3
PIM2 95 1
PIM3 29 4
SRPK1 105 10
EF2K 77 3
HIPK1 53 3
HIPK2 23 7
HIPK3 69 5
CLK2 27 0
PAK2 50 1
PAK4 42 5
PAK5 38 0
PAK6 56 3
MST2 4 1
MST4 14 1
GCK 4 1
MINK1 7 2
MEKK1 40 11
MLK1 27 2
MLK3 4 1
TAO1 28 6
ASK1 21 1
TAK1 5 2
IRAK4 46 4
RIPK2 70 6
TTK 44 1
Src 89 10
Lck 65 11
CSK 88 1
YES1 57 0
BTK 70 7
JAK2 6 1
SYK 43 4
EPH-A2 99 7
EPH-A4 87 2
EPH-B1 102 0
EPH-B2 105 8
EPH-B3 91 1
EPH-B4 95 1
FGF-R1 49 0
HER4 46 3
IGF-1R 72 10
IR 32 4
IRR 54 2
TrkA 56 4
VEGFR1 23 1
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 10 0
MKK2 34 4
MKK6 95 2
ERK1 72 3
ERK2 69 3
JNK1 90 3
JNK2 91 10
JNK3 97 6
p38 alpha MAPK 100 3
p38 beta MAPK 95 4
p38 gamma MAPK 98 9
p38 delta MAPK 92 1
ERK8 85 6
RSK1 14 1
RSK2 15 1
PDK1 35 4
PKB alpha 94 9
PKB beta 86 3
SGK1 98 2
S6K1 82 5
PKA 86 1
ROCK 2 54 1
PRK2 71 2
PKC alpha 79 4
PKC zeta 89 3
PKD1 19 5
MSK1 82 5
MNK1 114 9
MNK2 123 3
MAPKAP-K2 101 5
MAPKAP-K3 94 6
PRAK 86 3
CAMKK beta 87 5
CAMK1 91 1
SmMLCK 77 2
PHK 69 2
DAPK1 81 1
CHK1 53 3
CHK2 46 14
GSK3 beta 64 2
CDK2-Cyclin A 74 2
PLK1 79 5
Aurora A 103 8
Aurora B 97 5
LKB1 77 4
AMPK 46 1
MARK1 55 3
MARK2 73 3
MARK3 35 0
MARK4 65 7
BRSK1 82 1
BRSK2 84 5
MELK 71 3
NUAK1 30 1
CK1 delta 83 1
CK2 89 7
DYRK1A 100 1
DYRK2 91 11
DYRK3 89 2
NEK2a 55 6
NEK6 99 6
IKK beta 56 6
IKK epsilon 8 0
TBK1 11 0
PIM1 94 7
PIM2 91 7
PIM3 72 6
SRPK1 96 7
EF2K 83 3
HIPK1 78 1
HIPK2 56 1
HIPK3 98 0
CLK2 61 4
PAK2 77 7
PAK4 72 3
PAK5 76 7
PAK6 64 0
MST2 15 1
MST4 32 0
GCK 11 0
MINK1 15 2
MEKK1 51 9
MLK1 26 2
MLK3 8 1
TAO1 59 2
ASK1 67 7
TAK1 41 7
IRAK4 61 0
RIPK2 82 6
TTK 68 1
Src 86 2
Lck 84 11
CSK 85 5
YES1 81 1
BTK 87 1
JAK2 14 1
SYK 74 5
EPH-A2 109 14
EPH-A4 95 2
EPH-B1 105 3
EPH-B2 112 3
EPH-B3 93 13
EPH-B4 98 0
FGF-R1 76 0
HER4 73 5
IGF-1R 99 4
IR 65 12
IRR 73 2
TrkA 73 4
VEGFR1 47 5

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