Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
VX-680 C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262 Tocris Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 48 1
ERK1 96 4
ERK2 96 0
JNK1 100 2
JNK2 102 8
JNK3 96 1
p38 alpha MAPK 104 1
p38 beta MAPK 91 5
p38 gamma MAPK 98 5
p38 delta MAPK 90 1
ERK8 93 1
RSK1 31 5
RSK2 57 6
PDK1 91 4
PKB alpha 103 6
PKB beta 102 3
SGK1 80 7
S6K1 84 2
PKA 60 6
ROCK 2 86 1
PRK2 61 7
PKC alpha 93 3
PKC zeta 76 6
PKD1 100 4
MSK1 85 1
MNK1 88 4
MNK2 96 2
MAPKAP-K2 83 6
MAPKAP-K3 87 1
PRAK 86 2
CAMKK alpha 89 4
CAMKK beta 86 7
CAMK1 86 4
SmMLCK 102 7
PHK 58 2
CHK1 77 3
CHK2 93 4
GSK3 beta 78 4
CDK2-Cyclin A 86 2
PLK1 94 6
Aurora B 7 1
Aurora C 17 0
AMPK 80 6
MARK3 74 3
BRSK2 62 1
MELK 20 1
CK1 delta 104 5
CK2 102 1
DYRK1A 91 6
DYRK2 83 2
DYRK3 102 5
NEK2a 90 2
NEK6 86 1
NEK7 102 1
IKK beta 84 5
PIM1 88 2
PIM2 99 3
PIM3 77 6
SRPK1 82 6
EF2K 93 3
HIPK2 93 4
HIPK3 94 5
PAK4 38 1
PAK5 60 3
PAK6 69 6
MST2 54 2
Src 23 3
Lck 10 4
CSK 71 7
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 36 5
ERK1 112 5
ERK2 99 6
JNK1 77 0
JNK2 79 5
JNK3 83 0
p38 alpha MAPK 92 6
p38 beta MAPK 99 1
p38 gamma MAPK 86 1
p38 delta MAPK 66 3
ERK8 84 3
RSK1 25 6
RSK2 20 2
PDK1 88 0
PKB alpha 90 6
PKB beta 104 4
SGK1 68 1
S6K1 54 1
PKA 66 7
ROCK 2 75 0
PRK2 66 1
PKC alpha 55 2
PKC zeta 66 3
PKD1 86 3
MSK1 69 1
MNK1 78 0
MNK2 83 5
MAPKAP-K2 96 4
MAPKAP-K3 97 5
PRAK 91 7
CAMKK alpha 49 0
CAMKK beta 63 6
CAMK1 68 6
SmMLCK 89 9
PHK 22 1
CHK1 51 4
CHK2 66 2
GSK3 beta 58 5
CDK2-Cyclin A 67 4
PLK1 86 5
Aurora B 8 1
Aurora C 7 1
AMPK 68 3
MARK3 66 3
BRSK2 58 4
MELK 3 0
CK1 delta 97 4
CK2 99 5
DYRK1A 77 7
DYRK2 101 1
DYRK3 96 1
NEK2a 64 3
NEK6 79 1
NEK7 105 3
IKK beta 72 4
PIM1 96 6
PIM2 83 1
PIM3 46 3
SRPK1 75 3
EF2K 103 1
HIPK2 73 3
HIPK3 104 1
PAK4 10 0
PAK5 25 0
PAK6 55 3
MST2 15 3
Src 3 0
Lck 2 0
CSK 44 1

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