Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
VX-745 C19H9Cl2F2N3OS 436.26 p38 MAPK Tsai YR Epub 2013 Jan 21 Eur J Pharmacol. 2013 Feb 15 701(1-3) 96-105 WO1998027098 Selleck Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 98 2
ERK1 103 0
ERK2 105 0
JNK1 114 19
JNK2 111 6
p38 alpha MAPK 17 6
p38 beta MAPK 66 8
p38 gamma MAPK 95 19
p38 delta MAPK 119 24
ERK8 111 26
RSK1 109 6
RSK2 85 4
PDK1 111 6
PKB alpha 95 6
PKB beta 93 1
SGK1 127 21
S6K1 112 19
PKA 103 9
ROCK 2 96 4
PRK2 89 14
PKC alpha 102 9
PKC zeta 111 0
PKD1 112 19
MSK1 91 6
MNK1 75 1
MNK2 94 1
MAPKAP-K2 107 2
PRAK 96 8
CAMKK beta 110 4
CAMK1 93 17
SmMLCK 120 1
PHK 50 3
CHK1 113 4
CHK2 106 3
GSK3 beta 112 4
CDK2-Cyclin A 101 17
PLK1 118 15
Aurora B 99 18
LKB1 96 3
AMPK 100 3
MARK3 112 2
BRSK2 94 11
MELK 101 13
NUAK1 101 3
CK1 delta 100 1
CK2 94 4
DYRK1A 101 11
DYRK2 108 0
DYRK3 104 0
NEK2a 111 1
NEK6 101 0
IKK beta 98 8
IKK epsilon 105 3
TBK1 108 2
PIM1 101 16
PIM2 114 9
PIM3 100 13
SRPK1 106 9
EF2K 99 31
HIPK2 107 15
PAK4 107 4
PAK5 99 4
PAK6 96 9
MST2 132 16
MST4 103 1
GCK 104 2
MINK1 120 2
MLK1 91 3
MLK3 102 10
IRAK4 100 7
TTK 106 16
Src 93 9
Lck 103 13
CSK 115 3
YES1 103 3
BTK 98 7
SYK 114 0
EPH-A2 123 5
EPH-B3 89 6
FGF-R1 106 4
HER4 119 5
IGF-1R 115 4
IR 86 9
IRR 101 4
VEGFR1 117 2
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 86 7
MKK2 71 1
MKK6 104 4
ERK1 95 2
ERK2 84 1
JNK1 93 2
JNK2 84 7
JNK3 91 1
p38 alpha MAPK 4 0
p38 beta MAPK 20 2
p38 gamma MAPK 82 5
p38 delta MAPK 89 3
ERK8 109 4
RSK1 104 3
RSK2 78 1
PDK1 91 1
PKB alpha 98 6
PKB beta 91 7
SGK1 100 12
S6K1 90 6
PKA 90 4
ROCK 2 80 6
PRK2 89 6
PKC alpha 97 6
PKC zeta 106 6
PKD1 96 7
MSK1 86 2
MNK1 94 2
MNK2 97 7
MAPKAP-K2 94 7
MAPKAP-K3 89 2
PRAK 95 5
CAMKK beta 86 0
CAMK1 86 5
SmMLCK 74 5
PHK 116 3
DAPK1 80 10
CHK1 78 2
CHK2 90 6
GSK3 beta 83 3
CDK2-Cyclin A 106 3
PLK1 106 5
Aurora A 103 2
Aurora B 85 9
LKB1 93 0
AMPK 81 5
MARK1 84 4
MARK2 92 4
MARK3 98 2
MARK4 96 3
BRSK1 106 2
BRSK2 88 11
MELK 87 8
NUAK1 89 4
CK1 delta 99 5
CK2 119 3
DYRK1A 104 10
DYRK2 86 3
DYRK3 95 12
NEK2a 85 2
NEK6 97 11
IKK beta 95 4
IKK epsilon 95 7
TBK1 89 7
PIM1 91 8
PIM2 105 4
PIM3 80 3
SRPK1 95 7
EF2K 84 3
HIPK1 101 2
HIPK2 97 7
HIPK3 102 7
CLK2 76 15
PAK2 93 6
PAK4 91 9
PAK5 80 2
PAK6 83 14
MST2 95 12
MST4 98 1
GCK 98 2
MINK1 95 3
MEKK1 96 5
MLK1 97 6
MLK3 85 10
TAO1 83 3
ASK1 106 13
TAK1 91 10
IRAK4 88 0
RIPK2 110 12
TTK 97 1
Src 92 15
Lck 89 1
CSK 89 7
YES1 91 6
BTK 84 11
JAK2 101 7
SYK 99 2
EPH-A2 96 1
EPH-A4 103 4
EPH-B1 92 4
EPH-B2 97 11
EPH-B3 93 9
EPH-B4 95 4
FGF-R1 116 14
HER4 99 1
IGF-1R 103 5
IR 88 15
IRR 105 7
TrkA 89 11
VEGFR1 80 12
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 7
MKK2 93 2
MKK6 111 6
ERK1 93 7
ERK2 100 15
JNK1 89 6
JNK2 94 2
JNK3 92 6
p38 alpha MAPK 5 1
p38 beta MAPK 28 5
p38 gamma MAPK 84 13
p38 delta MAPK 77 3
ERK8 101 6
RSK1 104 1
RSK2 95 11
PDK1 93 3
PKB alpha 87 3
PKB beta 91 7
SGK1 103 3
S6K1 92 10
PKA 99 11
ROCK 2 87 4
PRK2 84 10
PKC alpha 97 1
PKC zeta 99 3
PKD1 86 5
MSK1 89 3
MNK1 124 1
MNK2 109 9
MAPKAP-K2 96 3
MAPKAP-K3 86 5
PRAK 95 5
CAMKK beta 89 5
CAMK1 104 8
SmMLCK 83 3
PHK 114 0
DAPK1 86 5
CHK1 97 2
CHK2 107 6
GSK3 beta 91 4
CDK2-Cyclin A 110 2
PLK1 99 12
Aurora A 98 7
Aurora B 88 0
LKB1 87 6
AMPK 97 2
MARK1 95 2
MARK2 86 0
MARK3 93 0
MARK4 103 2
BRSK1 103 3
BRSK2 87 8
MELK 96 1
NUAK1 94 2
CK1 delta 93 5
CK2 106 8
DYRK1A 109 0
DYRK2 103 7
DYRK3 104 1
NEK2a 83 3
NEK6 103 15
IKK beta 93 2
IKK epsilon 97 1
TBK1 94 6
PIM1 94 9
PIM2 108 5
PIM3 86 4
SRPK1 97 1
EF2K 90 1
HIPK1 98 1
HIPK2 91 0
HIPK3 102 2
CLK2 81 8
PAK2 98 10
PAK4 93 5
PAK5 94 1
PAK6 95 6
MST2 96 2
MST4 92 3
GCK 96 4
MINK1 107 15
MEKK1 95 12
MLK1 104 1
MLK3 91 2
TAO1 102 2
ASK1 105 12
TAK1 89 3
IRAK4 81 5
RIPK2 102 5
TTK 85 1
Src 93 1
Lck 101 11
CSK 99 5
YES1 95 4
BTK 102 1
JAK2 85 9
SYK 113 4
EPH-A2 89 7
EPH-A4 106 11
EPH-B1 97 1
EPH-B2 94 13
EPH-B3 95 1
EPH-B4 92 2
FGF-R1 105 9
HER4 99 6
IGF-1R 89 15
IR 108 8
IRR 83 2
TrkA 89 9
VEGFR1 100 12

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