Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Uo126 C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623 Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839 Tocris Download

Results as Barchart

View results as a bar chart
5µM
10µM

Results as Table

Screening Concentration: 5µM
Kinase % Activity Remaining Standard Deviation
MKK1 66 2
ERK1 79 2
ERK2 81 6
JNK1 77 1
JNK2 84 2
JNK3 78 2
p38 alpha MAPK 48 1
p38 beta MAPK 64 1
p38 gamma MAPK 87 4
p38 delta MAPK 96 4
ERK8 71 4
RSK1 94 9
RSK2 83 0
PDK1 91 6
PKB alpha 94 6
PKB beta 81 6
SGK1 70 3
S6K1 82 1
PKA 52 0
ROCK 2 64 5
PRK2 97 4
PKC alpha 83 8
PKC zeta 65 4
PKD1 73 0
MSK1 76 5
MNK1 56 7
MNK2 74 1
MAPKAP-K2 98 5
MAPKAP-K3 79 2
PRAK 67 0
CAMKK alpha 76 1
CAMKK beta 91 1
CAMK1 81 1
SmMLCK 81 6
PHK 75 4
CHK1 98 3
CHK2 85 8
GSK3 beta 62 5
CDK2-Cyclin A 89 0
PLK1 68 8
Aurora B 71 3
Aurora C 87 9
AMPK 58 6
MARK3 82 7
BRSK2 58 2
MELK 75 4
CK1 delta 102 2
CK2 85 1
DYRK1A 92 2
DYRK2 71 1
DYRK3 54 5
NEK2a 90 6
NEK6 90 3
NEK7 77 9
IKK beta 74 1
PIM1 86 7
PIM2 65 9
PIM3 74 2
SRPK1 91 0
EF2K 75 5
HIPK2 106 5
HIPK3 87 2
PAK4 64 3
PAK5 66 1
PAK6 63 3
MST2 70 8
Src 83 7
Lck 63 6
CSK 77 6
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 24 1
ERK1 72 5
ERK2 68 3
JNK1 90 2
JNK2 73 4
JNK3 98 4
p38 alpha MAPK 77 6
p38 beta MAPK 91 9
p38 gamma MAPK 90 1
p38 delta MAPK 93 7
ERK8 67 3
RSK1 83 6
RSK2 81 1
PDK1 77 3
PKB alpha 76 8
PKB beta 98 1
SGK1 72 6
S6K1 93 5
PKA 93 5
ROCK 2 81 6
PRK2 85 9
PKC alpha 95 5
PKC zeta 78 2
PKD1 77 6
MSK1 85 7
MNK1 78 2
MNK2 85 8
MAPKAP-K2 95 2
MAPKAP-K3 97 15
PRAK 92 2
CAMKK alpha 99 11
CAMKK beta 92 6
CAMK1 69 4
SmMLCK 95 5
PHK 94 7
CHK1 83 3
CHK2 98 3
GSK3 beta 82 5
CDK2-Cyclin A 86 1
PLK1 92 7
Aurora B 86 3
Aurora C 88 11
AMPK 76 12
MARK3 95 5
BRSK2 87 12
MELK 83 11
CK1 delta 90 10
CK2 99 4
DYRK1A 69 4
DYRK2 84 3
DYRK3 77 4
NEK2a 89 7
NEK6 90 3
NEK7 97 6
IKK beta 118 7
PIM1 87 0
PIM2 101 3
PIM3 63 8
SRPK1 102 6
EF2K 116 5
HIPK2 97 3
HIPK3 87 7
PAK4 94 4
PAK5 86 2
PAK6 85 11
MST2 96 5
Src 84 6
Lck 84 4
CSK 88 12

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