Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SU-6656 C19H21N3O3S 371.5 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319 Blake R.A. (2000) Mol. Cell. Biol. 20 9018 Sigma Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 28 2
MKK2 41 7
MKK6 82 9
ERK1 94 12
ERK2 76 11
JNK1 103 15
JNK2 90 2
JNK3 85 1
p38 alpha MAPK 80 0
p38 beta MAPK 80 5
p38 gamma MAPK 102 5
p38 delta MAPK 88 6
ERK8 29 3
RSK1 27 2
RSK2 62 0
PDK1 91 3
PKB alpha 94 1
PKB beta 79 23
SGK1 69 15
S6K1 63 10
PKA 82 1
ROCK 2 19 3
PRK2 21 2
PKC alpha 95 1
PKC gamma 95 1
PKC zeta 100 3
PKD1 108 14
STK33 23 2
MSK1 83 8
MNK1 100 7
MNK2 89 10
MAPKAP-K2 102 16
MAPKAP-K3 64 1
PRAK 62 2
CAMKK beta 9 1
CAMK1 78 3
SmMLCK 69 1
PHK 51 8
DAPK1 83 7
CHK1 55 10
CHK2 11 3
GSK3 beta 76 20
CDK2-Cyclin A 68 39
CDK9-Cyclin T1 65 10
PLK1 114 11
Aurora A 3 2
Aurora B 2 0
TLK1 96 11
LKB1 96 16
AMPK 10 2
AMPK (hum) 3 3
MARK1 53 31
MARK2 75 23
MARK3 38 3
MARK4 21 0
BRSK1 18 2
BRSK2 6 2
MELK 80 10
NUAK1 6 0
SIK2 62 1
SIK3 51 0
TSSK1 51 14
CK1 gamma 2 100 10
CK1 delta 74 4
CK2 94 11
TTBK1 91 7
TTBK2 112 22
DYRK1A 30 7
DYRK2 87 2
DYRK3 85 14
NEK2a 57 14
NEK6 80 5
IKK beta 87 9
IKK epsilon 21 2
TBK1 56 8
PIM1 104 5
PIM2 94 1
PIM3 84 11
SRPK1 6 1
EF2K 77 12
EIF2AK3 102 8
HIPK1 90 8
HIPK2 66 9
HIPK3 107 6
CLK2 7 1
PAK2 90 2
PAK4 36 1
PAK5 95 11
PAK6 103 28
MST2 6 2
MST3 23 2
MST4 51 48
GCK 6 1
MAP4K3 3 1
MAP4K5 4 0
MINK1 37 8
MEKK1 75 12
MLK1 45 8
MLK3 25 3
TESK1 51 7
TAO1 50 15
ASK1 66 4
TAK1 56 6
IRAK1 1 1
IRAK4 6 1
RIPK2 48 2
OSR1 51 5
TTK 44 7
MPSK1 98 3
WNK1 98 8
ULK1 2 1
ULK2 7 7
Src 11 4
Lck 12 2
CSK 44 10
YES1 3 1
ABL 36 5
BTK 53 5
JAK2 0 2
SYK 44 5
ZAP70 103 3
TIE2 74 3
BRK 64 12
EPH-A2 41 0
EPH-A4 41 6
EPH-B1 89 3
EPH-B2 41 4
EPH-B3 37 2
EPH-B4 76 20
FGF-R1 21 0
HER4 90 5
IGF-1R 60 30
IR 29 16
IRR 59 3
TrkA 5 2
DDR2 24 2
VEGFR1 19 6
PDGFRA 31 7
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 38 11
MKK2 56 4
MKK6 93 12
ERK1 95 10
ERK2 75 6
JNK1 83 9
JNK2 91 3
JNK3 104 7
p38 alpha MAPK 85 2
p38 beta MAPK 88 7
p38 gamma MAPK 101 9
p38 delta MAPK 89 7
ERK8 65 4
RSK1 38 9
RSK2 66 11
PDK1 104 20
PKB alpha 102 4
PKB beta 103 14
SGK1 92 15
S6K1 78 1
PKA 89 4
ROCK 2 46 2
PRK2 26 3
PKC alpha 106 15
PKC gamma 101 4
PKC zeta 114 3
PKD1 102 4
STK33 30 1
MSK1 98 5
MNK1 111 6
MNK2 97 2
MAPKAP-K2 102 10
MAPKAP-K3 86 12
PRAK 83 15
CAMKK alpha 20 4
CAMKK beta 12 4
CAMK1 101 2
SmMLCK 79 2
PHK 52 6
DAPK1 95 10
CHK1 49 3
CHK2 14 1
GSK3 beta 88 6
CDK2-Cyclin A 92 0
CDK9-Cyclin T1 101 9
PLK1 105 5
Aurora A 2 1
Aurora B 3 0
Aurora C 7 0
TLK1 101 12
LKB1 79 10
AMPK 17 0
AMPK (hum) 4 1
MARK1 45 18
MARK2 37 0
MARK3 35 4
MARK4 53 1
BRSK1 13 1
BRSK2 13 1
MELK 79 5
NUAK1 56 75
SIK2 59 3
SIK3 54 12
TSSK1 50 23
CK1 gamma 2 109 3
CK1 delta 104 6
CK2 93 1
TTBK1 91 9
TTBK2 74 17
DYRK1A 45 4
DYRK2 88 7
DYRK3 87 1
NEK2a 66 2
NEK6 106 8
IKK beta 89 13
IKK epsilon 33 0
TBK1 66 3
PIM1 112 1
PIM2 106 6
PIM3 65 0
SRPK1 19 5
EF2K 91 7
EIF2AK3 101 0
HIPK1 102 6
HIPK2 72 12
HIPK3 118 15
CLK2 5 1
PAK2 99 3
PAK4 73 1
PAK5 75 2
PAK6 80 0
MST2 7 1
MST3 42 1
MST4 21 2
GCK 7 0
MAP4K3 1 0
MAP4K5 4 0
MINK1 58 34
MEKK1 72 3
MLK1 33 6
MLK3 32 5
TESK1 51 11
TAO1 60 2
ASK1 86 3
TAK1 55 6
IRAK1 2 0
IRAK4 10 4
RIPK2 51 2
OSR1 74 0
TTK 58 2
MPSK1 95 2
WNK1 104 5
ULK1 1 1
ULK2 8 1
Src 12 4
Lck 12 0
CSK 85 1
YES1 3 0
ABL 32 3
BTK 62 9
JAK2 2 4
SYK 71 8
ZAP70 102 1
TIE2 71 14
BRK 26 5
EPH-A2 75 6
EPH-A4 64 12
EPH-B1 90 1
EPH-B2 91 2
EPH-B3 77 5
EPH-B4 70 6
FGF-R1 37 4
HER4 76 31
IGF-1R 96 25
IR 35 6
IRR 80 39
TrkA 49 66
DDR2 31 1
VEGFR1 64 58

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