Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SU-5416 (VEGFR2 Kinase Inhibitor III) C15H14N2O 238.3 VEGF-R Tille J.C. (2003) Exp. Cell Res. 285 286 Itokawa T. (2002) Mol. Cancer Ther. 1 295 Tocris Download

Results as Barchart

View results as a bar chart
10µM
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 50 2
MKK2 60 4
MKK6 122 1
ERK1 89 10
ERK2 107 7
JNK1 98 7
JNK2 104 10
JNK3 90 4
p38 alpha MAPK 113 5
p38 beta MAPK 110 4
p38 gamma MAPK 98 4
p38 delta MAPK 112 9
ERK8 105 12
RSK1 46 2
RSK2 72 1
PDK1 87 3
PKB alpha 104 1
PKB beta 88 2
SGK1 94 6
S6K1 98 3
PKA 107 13
ROCK 2 100 5
PRK2 98 4
PKC alpha 126 6
PKC zeta 127 10
PKD1 93 15
MSK1 95 6
MNK1 97 8
MNK2 112 5
MAPKAP-K2 110 5
MAPKAP-K3 86 7
PRAK 114 7
CAMKK beta 86 4
CAMK1 107 3
SmMLCK 41 2
PHK 24 3
DAPK1 74 6
CHK1 85 2
CHK2 17 3
GSK3 beta 104 2
CDK2-Cyclin A 71 6
PLK1 99 8
Aurora A 63 1
Aurora B 68 1
LKB1 83 8
AMPK 65 10
MARK1 91 2
MARK2 97 6
MARK3 92 13
MARK4 77 1
BRSK1 91 1
BRSK2 96 6
MELK 69 5
NUAK1 40 6
CK1 delta 56 4
CK2 99 10
DYRK1A 86 4
DYRK2 106 2
DYRK3 88 3
NEK2a 92 10
NEK6 108 5
IKK beta 89 12
IKK epsilon 72 5
TBK1 77 10
PIM1 74 3
PIM2 112 0
PIM3 95 2
SRPK1 105 5
EF2K 90 4
HIPK1 109 8
HIPK2 71 2
HIPK3 121 6
CLK2 32 7
PAK2 107 2
PAK4 122 11
PAK5 101 9
PAK6 119 4
MST2 42 1
MST4 108 11
GCK 58 4
MINK1 37 7
MEKK1 25 4
MLK1 43 5
MLK3 18 0
TAO1 93 0
ASK1 77 15
TAK1 52 9
IRAK4 40 10
RIPK2 95 5
TTK 89 10
Src 103 4
Lck 77 1
CSK 91 2
YES1 73 10
BTK 106 11
JAK2 60 11
SYK 110 3
EPH-A2 109 11
EPH-A4 107 15
EPH-B1 100 14
EPH-B2 115 7
EPH-B3 112 4
EPH-B4 101 3
FGF-R1 78 12
HER4 75 3
IGF-1R 52 3
IR 16 1
IRR 103 1
TrkA 25 4
VEGFR1 28 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 79 4
MKK2 96 7
MKK6 108 0
ERK1 81 3
ERK2 87 1
JNK1 97 8
JNK2 99 3
JNK3 87 10
p38 alpha MAPK 102 4
p38 beta MAPK 92 0
p38 gamma MAPK 93 0
p38 delta MAPK 124 6
ERK8 106 1
RSK1 97 6
RSK2 91 3
PDK1 99 15
PKB alpha 104 6
PKB beta 91 6
SGK1 107 3
S6K1 91 9
PKA 90 4
ROCK 2 103 7
PRK2 104 8
PKC alpha 102 2
PKC zeta 115 0
PKD1 90 8
MSK1 88 6
MNK1 99 2
MNK2 96 3
MAPKAP-K2 115 5
MAPKAP-K3 94 2
PRAK 96 8
CAMKK beta 95 6
CAMK1 120 2
SmMLCK 87 1
PHK 74 5
DAPK1 87 1
CHK1 95 11
CHK2 72 2
GSK3 beta 81 3
CDK2-Cyclin A 75 1
PLK1 98 13
Aurora A 122 10
Aurora B 80 3
LKB1 86 1
AMPK 85 5
MARK1 88 6
MARK2 93 5
MARK3 106 3
MARK4 100 2
BRSK1 99 1
BRSK2 102 10
MELK 86 1
NUAK1 79 8
CK1 delta 92 3
CK2 88 4
DYRK1A 108 8
DYRK2 97 1
DYRK3 93 1
NEK2a 95 5
NEK6 103 11
IKK beta 97 3
IKK epsilon 99 6
TBK1 92 2
PIM1 104 11
PIM2 107 6
PIM3 92 8
SRPK1 109 0
EF2K 76 0
HIPK1 98 3
HIPK2 83 10
HIPK3 106 11
CLK2 66 12
PAK2 101 6
PAK4 102 7
PAK5 98 2
PAK6 93 2
MST2 89 6
MST4 97 2
GCK 93 3
MINK1 74 7
MEKK1 73 8
MLK1 84 4
MLK3 49 3
TAO1 76 12
ASK1 91 3
TAK1 90 1
IRAK4 80 9
RIPK2 101 6
TTK 100 15
Src 96 2
Lck 101 3
CSK 87 0
YES1 104 0
BTK 110 8
JAK2 84 1
SYK 102 6
EPH-A2 105 14
EPH-A4 110 1
EPH-B1 117 14
EPH-B2 101 0
EPH-B3 108 10
EPH-B4 94 6
FGF-R1 96 0
HER4 90 7
IGF-1R 88 6
IR 60 9
IRR 106 9
TrkA 29 3
VEGFR1 45 3
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 22 1
ERK2 72 1
JNK1 86 1
JNK3 75 1
p38 alpha MAPK 72 0
p38 beta MAPK 85 2
p38 gamma MAPK 78 2
p38 delta MAPK 69 7
ERK8 54 3
RSK1 11 3
RSK2 15 3
PDK1 58 6
PKB alpha 81 1
PKB beta 88 1
SGK1 13 4
S6K1 19 1
MNK2 91 1
MAPKAP-K3 80 6
PRAK 65 4
SmMLCK 22 4
PHK 3 0
CHK1 28 6
CHK2 6 2
GSK3 beta 84 4
CDK2-Cyclin A 91 5
PLK1 84 7
Aurora B 4 1
AMPK 42 8
MARK3 30 2
CK1 delta 21 3
CK2 80 8
DYRK1A 50 1
NEK2a 54 0
NEK6 90 7
NEK7 88 3
IKK beta 99 6
SRPK1 67 1
EF2K 79 1
MST2 5 0
Src 51 4
Lck 26 5
CSK 95 5

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