Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
STO 609 C19H10N2O3 • CH3CO2H 374.4 CaMKK Levine Y. (2007) J. Biol. Chem. 282 20351 Tokumitsu H. (2003) J. Biol. Chem. 278 10908 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 46 1
MKK2 95 7
MKK6 88 6
ERK1 108 8
ERK2 91 11
JNK1 96 2
JNK2 95 8
JNK3 53 7
p38 alpha MAPK 114 0
p38 beta MAPK 87 6
p38 gamma MAPK 96 3
p38 delta MAPK 109 10
ERK8 2 0
RSK1 93 4
RSK2 106 6
PDK1 112 11
PKB alpha 90 6
PKB beta 103 2
SGK1 60 15
S6K1 77 14
PKA 100 4
ROCK 2 112 4
PRK2 92 2
PKC alpha 84 8
PKC zeta 93 5
PKD1 105 7
MSK1 93 2
MNK1 14 1
MNK2 92 5
MAPKAP-K2 107 4
MAPKAP-K3 103 9
PRAK 102 1
CAMKK beta 5 1
CAMK1 100 5
SmMLCK 87 2
PHK 94 14
DAPK1 7 1
CHK1 97 13
CHK2 23 4
GSK3 beta 9 1
CDK2-Cyclin A 52 1
PLK1 93 6
Aurora A 111 7
Aurora B 113 4
LKB1 91 4
AMPK 30 1
MARK1 82 8
MARK2 110 1
MARK3 88 1
MARK4 74 1
BRSK1 94 6
BRSK2 87 7
MELK 76 4
NUAK1 33 8
CK1 delta 81 3
CK2 15 1
DYRK1A 18 1
DYRK2 32 1
DYRK3 36 0
NEK2a 53 0
NEK6 104 11
IKK beta 97 14
IKK epsilon 28 8
TBK1 27 1
PIM1 39 6
PIM2 14 2
PIM3 25 2
SRPK1 77 4
EF2K 31 6
HIPK1 93 6
HIPK2 50 6
HIPK3 88 3
CLK2 38 12
PAK2 111 14
PAK4 84 1
PAK5 104 4
PAK6 92 8
MST2 88 3
MST4 92 1
GCK 15 2
MINK1 49 3
MEKK1 36 1
MLK1 40 1
MLK3 16 3
TAO1 87 8
ASK1 100 13
TAK1 47 5
IRAK4 104 1
RIPK2 95 9
TTK 60 1
Src 112 1
Lck 107 9
CSK 97 1
YES1 99 7
BTK 100 0
JAK2 52 4
SYK 95 15
EPH-A2 102 11
EPH-A4 92 3
EPH-B1 122 1
EPH-B2 125 6
EPH-B3 95 2
EPH-B4 102 1
FGF-R1 98 0
HER4 102 8
IGF-1R 72 6
IR 47 7
IRR 44 5
TrkA 90 4
VEGFR1 57 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 67 3
MKK2 111 6
MKK6 88 4
ERK1 106 12
ERK2 85 3
JNK1 98 5
JNK2 94 8
JNK3 66 4
p38 alpha MAPK 93 7
p38 beta MAPK 86 12
p38 gamma MAPK 92 0
p38 delta MAPK 115 4
ERK8 6 1
RSK1 95 3
RSK2 85 4
PDK1 95 4
PKB alpha 90 3
PKB beta 91 9
SGK1 70 5
S6K1 86 0
PKA 94 8
ROCK 2 86 1
PRK2 89 7
PKC alpha 99 0
PKC zeta 88 9
PKD1 111 15
MSK1 95 4
MNK1 10 2
MNK2 109 6
MAPKAP-K2 103 9
MAPKAP-K3 109 6
PRAK 98 6
CAMKK beta 4 1
CAMK1 116 9
SmMLCK 93 6
PHK 108 8
DAPK1 54 1
CHK1 83 5
CHK2 47 11
GSK3 beta 73 5
CDK2-Cyclin A 83 3
PLK1 96 1
Aurora A 101 6
Aurora B 100 10
LKB1 87 1
AMPK 57 1
MARK1 108 3
MARK2 87 3
MARK3 92 6
MARK4 75 4
BRSK1 91 3
BRSK2 90 9
MELK 69 3
NUAK1 37 3
CK1 delta 92 14
CK2 64 2
DYRK1A 70 1
DYRK2 75 1
DYRK3 79 4
NEK2a 84 1
NEK6 90 12
IKK beta 97 14
IKK epsilon 72 4
TBK1 61 8
PIM1 87 7
PIM2 61 4
PIM3 25 1
SRPK1 87 5
EF2K 69 1
HIPK1 100 1
HIPK2 88 11
HIPK3 89 7
CLK2 71 1
PAK2 103 3
PAK4 88 5
PAK5 113 8
PAK6 88 0
MST2 89 1
MST4 91 2
GCK 62 5
MINK1 71 15
MEKK1 65 3
MLK1 73 2
MLK3 55 1
TAO1 97 6
ASK1 103 5
TAK1 85 10
IRAK4 107 11
RIPK2 93 3
TTK 78 1
Src 93 9
Lck 98 4
CSK 86 0
YES1 97 5
BTK 98 7
JAK2 68 9
SYK 101 10
EPH-A2 92 2
EPH-A4 97 3
EPH-B1 106 3
EPH-B2 112 14
EPH-B3 96 2
EPH-B4 90 0
FGF-R1 107 9
HER4 100 4
IGF-1R 90 9
IR 58 10
IRR 63 2
TrkA 85 0
VEGFR1 98 2
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 81 5
MKK2 106 1
MKK6 92 6
ERK1 117 11
ERK2 84 10
JNK1 95 1
JNK2 99 12
JNK3 82 4
p38 alpha MAPK 103 5
p38 beta MAPK 95 9
p38 gamma MAPK 96 5
p38 delta MAPK 111 8
ERK8 38 0
RSK1 91 2
RSK2 108 6
PDK1 102 3
PKB alpha 88 4
PKB beta 90 6
SGK1 84 8
S6K1 80 0
PKA 87 0
ROCK 2 88 1
PRK2 85 12
PKC alpha 105 12
PKC zeta 91 13
PKD1 101 3
MSK1 91 9
MNK1 30 3
MNK2 112 3
MAPKAP-K2 99 6
MAPKAP-K3 90 4
PRAK 102 3
CAMKK beta 9 1
CAMK1 117 7
SmMLCK 106 9
PHK 43 3
DAPK1 103 1
CHK1 101 1
CHK2 70 4
GSK3 beta 70 3
CDK2-Cyclin A 71 4
PLK1 105 11
Aurora A 117 3
Aurora B 96 10
LKB1 76 13
AMPK 64 7
MARK1 110 6
MARK2 98 5
MARK3 99 3
MARK4 81 3
BRSK1 91 1
BRSK2 96 4
MELK 90 13
NUAK1 69 11
CK1 delta 47 1
CK2 85 6
DYRK1A 44 0
DYRK2 88 0
DYRK3 74 0
NEK2a 94 5
NEK6 90 6
IKK beta 79 1
IKK epsilon 88 5
TBK1 100 12
PIM1 100 7
PIM2 105 4
PIM3 106 5
SRPK1 102 5
EF2K 84 4
HIPK1 101 0
HIPK2 93 8
HIPK3 96 2
CLK2 38 0
PAK2 111 12
PAK4 87 8
PAK5 108 4
PAK6 95 0
MST2 92 7
MST4 99 6
GCK 29 4
MINK1 62 7
MEKK1 103 11
MLK1 70 11
MLK3 90 0
TAO1 103 11
ASK1 96 15
TAK1 71 3
IRAK4 103 13
RIPK2 23 2
TTK 86 6
Src 76 5
Lck 73 5
CSK 83 6
YES1 50 3
BTK 89 3
JAK2 86 2
SYK 92 6
EPH-A2 91 8
EPH-A4 112 5
EPH-B1 70 5
EPH-B2 80 2
EPH-B3 78 9
EPH-B4 81 3
FGF-R1 90 5
HER4 104 9
IGF-1R 98 6
IR 46 12
IRR 69 3
TrkA 51 2
VEGFR1 18 0

Do you need any help? Please get in touch and we’ll be happy to lend a hand.