Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SRT 1720 C27H24F3N7O3S 583.59 SIRT1 Milne J.C. Lambert P.D. Schenk S. (2007) Nature 450 712-716 Cayman Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 87 8
MKK2 90 3
MKK6 98 8
ERK1 117 13
ERK2 97 5
JNK1 86 5
JNK2 87 4
JNK3 89 1
p38 alpha MAPK 99 5
p38 beta MAPK 90 1
p38 gamma MAPK 92 4
p38 delta MAPK 85 2
ERK8 86 1
RSK1 34 1
RSK2 46 2
PDK1 112 13
PKB alpha 88 8
PKB beta 61 6
SGK1 84 3
S6K1 61 11
PKA 84 9
ROCK 2 79 2
PRK2 104 8
PKC alpha 80 5
PKC zeta 103 0
PKD1 105 10
MSK1 68 6
MNK1 97 12
MNK2 96 1
MAPKAP-K2 59 5
MAPKAP-K3 100 11
PRAK 105 2
CAMKK beta 44 0
CAMK1 22 4
SmMLCK 10 3
PHK 14 1
DAPK1 25 7
CHK1 96 9
CHK2 54 5
GSK3 beta 67 5
CDK2-Cyclin A 115 8
PLK1 104 5
Aurora A 94 3
Aurora B 90 15
LKB1 97 2
AMPK 60 3
MARK1 74 6
MARK2 83 7
MARK3 99 2
MARK4 85 11
BRSK1 87 4
BRSK2 90 2
MELK 52 11
NUAK1 78 2
CK1 delta 91 5
CK2 77 2
DYRK1A 58 1
DYRK2 94 2
DYRK3 64 5
NEK2a 87 10
NEK6 83 9
IKK beta 84 5
IKK epsilon 83 8
TBK1 56 1
PIM1 10 2
PIM2 78 10
PIM3 24 0
SRPK1 86 4
EF2K 117 1
HIPK1 91 9
HIPK2 38 5
HIPK3 73 2
CLK2 18 3
PAK2 108 7
PAK4 96 7
PAK5 72 5
PAK6 87 4
MST2 92 9
MST4 77 6
GCK 99 6
MINK1 55 1
MEKK1 45 1
MLK1 40 8
MLK3 56 0
TAO1 97 6
ASK1 100 7
TAK1 86 2
IRAK4 24 0
RIPK2 95 14
TTK 68 5
Src 121 1
Lck 58 3
CSK 97 5
YES1 80 3
BTK 79 7
JAK2 86 14
SYK 67 9
EPH-A2 84 6
EPH-A4 76 6
EPH-B1 88 0
EPH-B2 84 2
EPH-B3 90 5
EPH-B4 103 1
FGF-R1 68 9
HER4 86 12
IGF-1R 25 2
IR 100 12
IRR 53 1
TrkA 30 4
VEGFR1 53 3
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 12
MKK2 109 1
MKK6 97 10
ERK1 105 8
ERK2 103 4
JNK1 103 12
JNK2 93 6
JNK3 105 0
p38 alpha MAPK 91 13
p38 beta MAPK 89 11
p38 gamma MAPK 95 1
p38 delta MAPK 78 1
ERK8 96 7
RSK1 66 3
RSK2 84 2
PDK1 97 0
PKB alpha 91 6
PKB beta 70 10
SGK1 94 5
S6K1 111 11
PKA 106 3
ROCK 2 89 12
PRK2 103 12
PKC alpha 106 2
PKC zeta 105 1
PKD1 92 10
MSK1 90 7
MNK1 100 8
MNK2 92 11
MAPKAP-K2 92 5
MAPKAP-K3 90 3
PRAK 91 1
CAMKK beta 83 2
CAMK1 83 1
SmMLCK 27 0
PHK 53 3
DAPK1 68 1
CHK1 98 1
CHK2 93 0
GSK3 beta 78 3
CDK2-Cyclin A 100 5
PLK1 94 6
Aurora A 102 3
Aurora B 93 1
LKB1 93 10
AMPK 88 2
MARK1 85 1
MARK2 106 0
MARK3 108 6
MARK4 110 3
BRSK1 94 6
BRSK2 97 0
MELK 74 4
NUAK1 106 2
CK1 delta 106 4
CK2 102 2
DYRK1A 94 8
DYRK2 94 10
DYRK3 91 4
NEK2a 95 3
NEK6 108 15
IKK beta 93 1
IKK epsilon 102 14
TBK1 91 5
PIM1 18 2
PIM2 95 9
PIM3 55 7
SRPK1 92 3
EF2K 106 4
HIPK1 104 2
HIPK2 86 6
HIPK3 92 8
CLK2 60 10
PAK2 107 1
PAK4 110 5
PAK5 91 4
PAK6 92 5
MST2 96 10
MST4 100 3
GCK 102 2
MINK1 91 5
MEKK1 92 4
MLK1 92 3
MLK3 88 7
TAO1 86 3
ASK1 98 2
TAK1 91 14
IRAK4 63 9
RIPK2 100 1
TTK 85 0
Src 93 8
Lck 106 15
CSK 85 8
YES1 82 7
BTK 99 9
JAK2 90 9
SYK 93 6
EPH-A2 99 4
EPH-A4 78 1
EPH-B1 102 3
EPH-B2 82 5
EPH-B3 99 6
EPH-B4 96 6
FGF-R1 91 13
HER4 80 11
IGF-1R 96 12
IR 101 5
IRR 77 1
TrkA 47 2
VEGFR1 89 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 91 0
ERK1 88 5
ERK2 93 16
JNK1 116 16
JNK2 101 12
p38 alpha MAPK 87 6
p38 beta MAPK 102 13
p38 gamma MAPK 84 8
p38 delta MAPK 91 7
ERK8 81 0
RSK1 88 6
RSK2 84 23
PDK1 108 9
PKB alpha 86 3
PKB beta 75 15
SGK1 89 5
S6K1 86 6
PKA 80 1
ROCK 2 100 6
PRK2 90 8
PKC alpha 114 2
PKC zeta 78 8
PKD1 87 10
MSK1 94 0
MNK1 92 4
MNK2 90 3
MAPKAP-K2 90 2
PRAK 101 11
CAMKK beta 92 1
CAMK1 109 5
SmMLCK 82 2
PHK 96 1
CHK1 86 5
CHK2 85 8
GSK3 beta 85 31
CDK2-Cyclin A 88 3
PLK1 84 13
AMPK 83 3
MARK3 100 4
BRSK2 86 5
MELK 97 3
CK1 delta 99 9
CK2 90 7
DYRK1A 101 3
DYRK2 98 19
DYRK3 82 1
NEK2a 91 3
NEK6 84 3
IKK beta 84 12
IKK epsilon 90 3
TBK1 97 0
PIM1 40 5
PIM2 90 0
PIM3 95 13
SRPK1 94 0
EF2K 102 4
HIPK3 88 6
PAK4 83 11
PAK5 79 11
PAK6 101 11
MST2 85 8
MST4 73 5
Src 85 1
Lck 88 9
CSK 97 4
YES1 69 9
BTK 88 3
SYK 109 8
EPH-A2 97 9
EPH-B3 99 14
FGF-R1 103 18
IGF-1R 92 3
IR 127 11
IRR 73 0
VEGFR1 90 18

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