Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SP600125 (JNK Inhibitor II, SAPK Inhibitor II) C14H8N2O 220.2 JNK Shin M. Boyd Y.D. (2002) Biochim. Biophys. Acta 1589 311 Bennett B.L. (2001) Proc. Natl. Acad. Sci. USA 98 13681 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 58 7
ERK1 88 4
ERK2 85 2
JNK1 22 1
JNK2 24 2
JNK3 47 0
p38 alpha MAPK 109 2
p38 beta MAPK 106 1
p38 gamma MAPK 85 1
p38 delta MAPK 82 2
ERK8 42 1
RSK1 55 0
RSK2 69 1
PDK1 55 5
PKB alpha 97 1
PKB beta 92 1
SGK1 27 0
S6K1 84 1
PKA 79 5
ROCK 2 91 2
PRK2 70 5
PKC alpha 67 5
PKC zeta 106 2
PKD1 25 0
MSK1 72 9
MNK1 67 3
MNK2 58 4
MAPKAP-K2 102 2
MAPKAP-K3 103 0
PRAK 58 8
CAMKK alpha 68 7
CAMKK beta 40 3
CAMK1 73 1
SmMLCK 34 4
PHK 30 0
CHK1 62 2
CHK2 44 4
GSK3 beta 81 4
CDK2-Cyclin A 49 1
PLK1 80 2
Aurora B 14 0
Aurora C 20 2
AMPK 44 4
MARK3 49 5
BRSK2 43 8
MELK 14 3
CK1 delta 15 0
CK2 57 4
DYRK1A 40 1
DYRK2 18 1
DYRK3 30 7
NEK2a 77 1
NEK6 102 4
NEK7 112 6
IKK beta 48 3
PIM1 39 2
PIM2 57 2
PIM3 17 0
SRPK1 83 4
EF2K 118 1
HIPK2 34 7
HIPK3 55 4
PAK4 60 3
PAK5 81 0
PAK6 71 5
MST2 31 4
Src 88 1
Lck 67 2
CSK 64 4

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