Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Sodium valproate C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734 Kostrouchova (2007) Folia Biologica 53 37 Sigma Download

Results as Barchart

View results as a bar chart
1µM
10µM
50µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 86 7
ERK2 98 4
JNK1 86 1
JNK3 88 4
p38 alpha MAPK 82 8
p38 beta MAPK 82 4
p38 gamma MAPK 93 1
p38 delta MAPK 106 12
ERK8 90 5
RSK1 99 1
RSK2 94 10
PDK1 98 10
PKB alpha 99 5
PKB beta 105 4
SGK1 89 13
S6K1 81 5
PKA 82 0
ROCK 2 84 8
PRK2 83 1
PKC alpha 88 1
PKD1 97 3
MSK1 94 7
MNK1 86 9
MNK2 90 10
MAPKAP-K2 85 0
MAPKAP-K3 90 5
PRAK 92 4
CAMK1 89 4
SmMLCK 98 3
PHK 110 1
CHK1 82 5
CHK2 83 0
GSK3 beta 74 8
CDK2-Cyclin A 90 1
PLK1 97 0
Aurora B 90 7
AMPK 98 8
MARK3 100 2
CK1 delta 108 2
CK2 105 0
DYRK1A 98 3
NEK2a 79 0
NEK6 99 1
NEK7 99 6
IKK beta 86 6
PIM2 83 4
SRPK1 94 0
EF2K 97 5
MST2 90 1
Src 100 12
Lck 84 3
CSK 94 28
Screening Concentration: 50µM
Kinase % Activity Remaining Standard Deviation
MKK1 99 10
MKK2 92 0
MKK6 81 0
ERK1 101 1
ERK2 80 4
JNK1 92 3
JNK2 104 8
JNK3 89 1
p38 alpha MAPK 109 1
p38 beta MAPK 106 13
p38 gamma MAPK 89 11
p38 delta MAPK 92 3
ERK8 94 15
RSK1 96 11
RSK2 93 5
PDK1 107 0
PKB alpha 102 2
PKB beta 80 3
SGK1 105 1
S6K1 91 8
PKA 93 5
ROCK 2 89 1
PRK2 103 4
PKC alpha 95 4
PKC zeta 93 1
PKD1 90 8
MSK1 91 5
MNK1 105 2
MNK2 126 6
MAPKAP-K2 99 5
MAPKAP-K3 97 11
PRAK 88 8
CAMKK beta 104 8
CAMK1 101 6
SmMLCK 96 1
PHK 81 1
DAPK1 94 9
CHK1 95 9
CHK2 95 10
GSK3 beta 76 5
CDK2-Cyclin A 80 8
PLK1 93 2
Aurora A 111 4
Aurora B 83 7
LKB1 85 6
AMPK 91 4
MARK1 101 1
MARK2 90 5
MARK3 105 1
MARK4 106 9
BRSK1 124 10
BRSK2 113 12
MELK 92 8
NUAK1 86 10
CK1 delta 90 3
CK2 86 2
DYRK1A 89 7
DYRK2 101 1
DYRK3 91 13
NEK2a 91 11
NEK6 102 2
IKK beta 88 3
IKK epsilon 81 2
TBK1 97 1
PIM1 100 14
PIM2 98 3
PIM3 95 4
SRPK1 108 0
EF2K 71 4
HIPK1 94 10
HIPK2 92 10
HIPK3 97 1
CLK2 86 6
PAK2 91 7
PAK4 90 9
PAK5 90 6
PAK6 104 5
MST2 87 14
MST4 100 3
GCK 98 4
MINK1 76 3
MEKK1 96 0
MLK1 102 5
MLK3 96 6
TAO1 89 4
ASK1 83 1
TAK1 103 1
IRAK4 99 5
RIPK2 90 6
TTK 82 1
Src 94 2
Lck 106 12
CSK 93 3
YES1 102 12
BTK 94 1
JAK2 86 5
SYK 98 2
EPH-A2 99 4
EPH-A4 104 0
EPH-B1 106 4
EPH-B2 126 1
EPH-B3 96 10
EPH-B4 97 2
FGF-R1 104 3
HER4 76 14
IGF-1R 56 6
IR 77 5
IRR 101 1
TrkA 89 9
VEGFR1 89 2
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 89 6
MKK2 102 4
MKK6 95 10
ERK1 88 2
ERK2 77 6
JNK1 95 7
JNK2 103 3
JNK3 85 7
p38 alpha MAPK 107 10
p38 beta MAPK 91 5
p38 gamma MAPK 95 8
p38 delta MAPK 95 10
ERK8 86 8
RSK1 100 9
RSK2 94 5
PDK1 106 5
PKB alpha 99 2
PKB beta 86 9
SGK1 98 10
S6K1 84 8
PKA 91 1
ROCK 2 97 9
PRK2 106 2
PKC alpha 91 1
PKC zeta 101 7
PKD1 104 3
MSK1 86 10
MNK1 112 3
MNK2 106 14
MAPKAP-K2 102 2
MAPKAP-K3 93 11
PRAK 91 2
CAMKK beta 98 1
CAMK1 107 4
SmMLCK 109 12
PHK 89 10
DAPK1 97 6
CHK1 95 1
CHK2 97 4
GSK3 beta 79 0
CDK2-Cyclin A 76 7
PLK1 95 9
Aurora A 107 1
Aurora B 99 0
LKB1 84 9
AMPK 94 2
MARK1 97 7
MARK2 104 11
MARK3 108 12
MARK4 106 1
BRSK1 102 0
BRSK2 114 14
MELK 97 3
NUAK1 88 1
CK1 delta 107 10
CK2 86 4
DYRK1A 105 10
DYRK2 102 9
DYRK3 87 2
NEK2a 93 2
NEK6 100 4
IKK beta 79 6
IKK epsilon 101 2
TBK1 99 3
PIM1 98 7
PIM2 104 8
PIM3 97 1
SRPK1 107 5
EF2K 61 7
HIPK1 84 6
HIPK2 86 6
HIPK3 89 1
CLK2 90 9
PAK2 86 3
PAK4 86 7
PAK5 101 4
PAK6 95 9
MST2 88 1
MST4 102 0
GCK 87 1
MINK1 68 12
MEKK1 107 4
MLK1 94 1
MLK3 104 4
TAO1 93 7
ASK1 92 5
TAK1 92 10
IRAK4 94 5
RIPK2 104 3
TTK 101 7
Src 87 2
Lck 114 4
CSK 91 6
YES1 91 7
BTK 104 4
JAK2 80 6
SYK 100 5
EPH-A2 95 0
EPH-A4 117 7
EPH-B1 107 11
EPH-B2 106 14
EPH-B3 103 9
EPH-B4 98 1
FGF-R1 104 3
HER4 80 8
IGF-1R 76 4
IR 66 7
IRR 101 1
TrkA 91 3
VEGFR1 84 8

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