Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SL-327 (MEK1-2 Inhibitor) C16H12F3N3S 335.4 MEK1, MEK2 Hetman M. (2002) J. Biol. Chem. 277 49577 Ohno M. (2001) Nat. Neurosci. 4 1238 Tocris Download

Results as Barchart

View results as a bar chart
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 5
ERK1 103 17
ERK2 87 5
JNK1 100 0
JNK2 93 4
JNK3 104 6
p38 alpha MAPK 92 1
p38 beta MAPK 110 5
p38 gamma MAPK 100 8
p38 delta MAPK 92 9
ERK8 89 5
RSK1 107 4
RSK2 97 0
PDK1 96 1
PKB alpha 93 1
PKB beta 83 3
SGK1 118 9
S6K1 88 1
PKA 86 1
ROCK 2 92 1
PRK2 105 5
PKC alpha 96 0
PKC zeta 91 3
PKD1 90 7
MSK1 103 3
MNK1 97 8
MNK2 107 8
MAPKAP-K2 103 8
MAPKAP-K3 107 4
PRAK 88 5
CAMKK beta 93 7
CAMK1 99 4
SmMLCK 70 6
PHK 112 1
CHK1 114 3
CHK2 97 1
GSK3 beta 92 6
CDK2-Cyclin A 89 4
PLK1 95 12
Aurora B 98 4
AMPK 102 5
MARK3 89 0
BRSK2 91 6
MELK 83 4
CK1 delta 106 1
CK2 91 5
DYRK1A 94 7
DYRK2 125 36
DYRK3 88 8
NEK2a 88 2
NEK6 91 5
NEK7 107 2
IKK beta 85 3
IKK epsilon 102 0
TBK1 100 2
PIM1 92 1
PIM2 99 6
PIM3 84 6
SRPK1 82 2
EF2K 89 2
HIPK2 94 10
PAK4 73 1
PAK5 104 1
PAK6 95 1
MST2 95 4
MST4 90 7
Src 92 1
Lck 91 8
CSK 77 2
YES1 92 15
BTK 103 4
SYK 76 11
EPH-A2 99 7
EPH-B3 65 7
FGF-R1 88 25
IGF-1R 77 8
IR 102 3
IRR 93 16
VEGFR1 73 0

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