Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SC514 ( IKK-2 Inhibitor) C9H8N2OS2 224.3 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817 Kishore N. (2003) J. Biol. Chem. 278 32861 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
20µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 83 8
ERK1 88 6
ERK2 96 9
JNK1 89 4
JNK2 93 7
JNK3 94 9
p38 alpha MAPK 102 9
p38 beta MAPK 99 8
p38 gamma MAPK 79 8
p38 delta MAPK 87 1
ERK8 47 2
RSK1 97 5
RSK2 90 6
PDK1 93 11
PKB alpha 81 7
PKB beta 103 8
SGK1 105 6
S6K1 84 9
PKA 85 2
ROCK 2 59 3
PRK2 35 1
PKC alpha 67 6
PKC zeta 75 10
PKD1 75 2
MSK1 86 8
MNK1 72 4
MNK2 91 3
MAPKAP-K2 97 3
MAPKAP-K3 92 3
PRAK 61 6
CAMKK alpha 90 4
CAMKK beta 87 1
CAMK1 87 7
SmMLCK 80 7
PHK 103 8
CHK1 69 9
CHK2 93 12
GSK3 beta 76 2
CDK2-Cyclin A 84 7
PLK1 99 7
Aurora B 50 4
Aurora C 70 2
AMPK 77 10
MARK3 64 5
BRSK2 77 2
MELK 80 5
CK1 delta 91 12
CK2 75 6
DYRK1A 41 1
DYRK2 66 4
DYRK3 47 6
NEK2a 90 5
NEK6 93 9
NEK7 114 1
IKK beta 28 1
IKK epsilon 93 1
TBK1 95 5
PIM1 40 6
PIM2 55 2
PIM3 25 4
SRPK1 82 3
EF2K 113 6
HIPK2 47 2
HIPK3 77 7
PAK4 88 4
PAK5 82 3
PAK6 89 11
MST2 69 6
MST4 114 3
Src 90 6
Lck 70 7
CSK 81 2
YES1 97 0
SYK 90 12
EPH-A2 74 2
FGF-R1 63 10
IRR 63 4
Screening Concentration: 20µM
Kinase % Activity Remaining Standard Deviation
MKK1 71 0
ERK1 98 12
ERK2 93 13
JNK1 84 14
JNK2 93 12
JNK3 84 4
p38 alpha MAPK 80 10
p38 beta MAPK 93 11
p38 gamma MAPK 96 15
p38 delta MAPK 88 7
ERK8 21 2
RSK1 75 12
RSK2 93 8
PDK1 86 14
PKB alpha 82 3
PKB beta 86 8
SGK1 81 3
S6K1 89 9
PKA 68 13
ROCK 2 48 10
PRK2 28 0
PKC alpha 57 12
PKC zeta 97 6
PKD1 46 3
MSK1 91 5
MNK1 51 5
MNK2 65 12
MAPKAP-K2 60 3
MAPKAP-K3 87 9
PRAK 57 1
CAMKK beta 78 3
CAMK1 68 5
SmMLCK 53 6
PHK 83 6
CHK1 64 13
CHK2 94 3
GSK3 beta 79 5
CDK2-Cyclin A 59 0
PLK1 113 7
Aurora B 32 4
Aurora C 49 15
AMPK 92 11
MARK3 73 2
BRSK2 74 8
MELK 67 5
CK1 delta 62 4
CK2 54 1
DYRK1A 41 3
DYRK2 62 4
DYRK3 40 2
NEK2a 83 0
NEK6 82 10
NEK7 101 1
IKK beta 17 2
IKK epsilon 108 6
TBK1 107 6
PIM1 25 5
PIM2 46 0
PIM3 12 1
SRPK1 78 9
EF2K 86 12
HIPK2 37 3
PAK4 97 4
PAK5 91 4
PAK6 98 12
MST2 79 3
MST4 107 5
Src 87 0
Lck 81 6
CSK 102 8
YES1 112 11
SYK 88 4
EPH-A2 67 10
FGF-R1 55 11
IRR 60 4

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