Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SB-415286 C16H10ClN3O5 359.73 GSK3 Coghlan (2000) Chem.Biol. 7 793 Cross (2001) J.Neurochem. 77 94 Tocris Download

Results as Barchart

View results as a bar chart
2µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 28 3
ERK1 94 9
ERK2 95 8
JNK1 95 1
JNK2 88 4
JNK3 90 6
p38 alpha MAPK 72 6
p38 beta MAPK 89 7
p38 gamma MAPK 98 7
p38 delta MAPK 82 2
ERK8 13 3
RSK1 31 2
RSK2 29 1
PDK1 62 2
PKB alpha 92 1
PKB beta 85 10
SGK1 82 6
S6K1 81 2
PKA 80 8
ROCK 2 79 4
PRK2 43 7
PKC alpha 39 3
PKC zeta 69 4
PKD1 64 8
MSK1 62 5
MNK1 77 8
MNK2 91 8
MAPKAP-K2 85 5
MAPKAP-K3 99 6
PRAK 81 5
CAMKK alpha 53 6
CAMKK beta 29 3
CAMK1 61 3
SmMLCK 65 8
PHK 84 3
CHK1 60 5
CHK2 69 10
GSK3 beta 4 1
CDK2-Cyclin A 18 1
PLK1 85 7
Aurora B 64 3
Aurora C 70 4
AMPK 33 4
MARK3 29 2
BRSK2 38 3
MELK 72 5
CK1 delta 68 4
CK2 97 1
DYRK1A 30 3
DYRK2 83 7
DYRK3 84 5
NEK2a 86 6
NEK6 74 1
NEK7 86 9
IKK beta 84 5
IKK epsilon 27 3
TBK1 12 1
PIM1 37 2
PIM2 46 3
PIM3 46 8
SRPK1 54 6
EF2K 94 2
HIPK2 63 2
HIPK3 85 6
PAK4 52 4
PAK5 67 2
PAK6 74 1
MST2 14 2
MST4 22 2
Src 77 7
Lck 66 3
CSK 89 2
YES1 72 4
SYK 82 1
EPH-A2 90 1
FGF-R1 24 2
IRR 34 0
Screening Concentration: 2µM
Kinase % Activity Remaining Standard Deviation
MKK1 58 11
ERK1 82 9
ERK2 78 3
JNK1 101 9
JNK2 101 13
JNK3 77 3
p38 alpha MAPK 79 2
p38 beta MAPK 83 9
p38 gamma MAPK 94 5
p38 delta MAPK 93 8
ERK8 16 5
RSK1 52 3
RSK2 50 4
PDK1 83 2
PKB alpha 92 7
PKB beta 85 2
SGK1 109 7
S6K1 85 1
PKA 108 9
ROCK 2 86 8
PRK2 71 6
PKC alpha 78 7
PKC zeta 91 13
PKD1 92 7
MSK1 87 8
MNK1 78 4
MNK2 105 4
MAPKAP-K2 75 2
MAPKAP-K3 105 0
PRAK 93 3
CAMKK beta 59 3
CAMK1 86 11
SmMLCK 63 6
PHK 75 11
CHK1 83 1
CHK2 60 3
GSK3 beta 5 1
CDK2-Cyclin A 62 4
PLK1 110 1
Aurora B 70 1
Aurora C 89 1
AMPK 52 8
MARK3 78 11
BRSK2 60 1
MELK 82 0
CK1 delta 79 5
CK2 99 1
DYRK1A 46 3
DYRK2 107 2
DYRK3 86 6
NEK2a 70 8
NEK6 77 6
NEK7 82 11
IKK beta 91 0
IKK epsilon 63 6
TBK1 43 4
PIM1 65 0
PIM2 70 1
PIM3 74 7
SRPK1 91 8
EF2K 103 6
HIPK2 87 10
HIPK3 91 9
PAK4 88 7
PAK5 95 6
PAK6 97 8
MST2 25 0
MST4 47 1
Src 70 6
Lck 83 1
CSK 113 2
YES1 79 13
SYK 82 6
EPH-A2 88 12
FGF-R1 58 6
IRR 56 11

Do you need any help? Please get in touch and we’ll be happy to lend a hand.