Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SB-203580 C21H16N3OSF 377.4 p38 MAPK Powell D.J. (2003) Mol. Cell Biol. 23 7794 Davies S.P. (2000) Biochem. J. 351 95 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
CK1 delta 0 0
p38 alpha MAPK 2 0
p38 beta MAPK 3 1
GSK3 beta 12 2
JNK2 16 0
AMPK 20 3
Lck 24 4
JNK3 29 0
RSK1 34 6
CSK 37 2
PKC alpha 42 0
Src 47 5
PKA 53 4
MELK 53 0
PIM3 54 3
BRSK2 58 4
PKD1 60 3
RSK2 60 7
PHK 62 2
Aurora B 63 4
MNK1 63 0
PRAK 64 6
ROCK 2 65 1
PKC zeta 65 8
SGK1 66 1
MARK3 66 3
CHK1 67 3
PRK2 67 1
PDK1 67 2
Aurora C 68 4
CAMKK alpha 72 4
SmMLCK 73 3
DYRK3 75 5
MST2 75 6
PKB alpha 77 7
JNK1 77 5
CAMKK beta 78 0
S6K1 78 4
MSK1 78 5
CAMK1 79 4
PKB beta 80 4
PAK4 80 6
ERK8 80 8
CDK2-Cyclin A 81 2
PIM1 81 0
SRPK1 81 7
ERK1 82 1
PAK6 82 1
NEK2a 83 2
PLK1 83 6
p38 gamma MAPK 83 4
p38 delta MAPK 83 3
MKK1 85 4
ERK2 85 1
NEK6 85 1
IKK beta 87 4
PAK5 88 4
DYRK2 88 8
MAPKAP-K3 88 8
CK2 89 3
HIPK2 90 1
DYRK1A 91 1
MNK2 92 1
HIPK3 99 7
EF2K 101 1
PIM2 106 8
CHK2 107 5
NEK7 108 3
MAPKAP-K2 111 4
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
CK1 delta 8 0
p38 alpha MAPK 9 0
p38 beta MAPK 12 0
GSK3 beta 34 2
RSK1 52 7
Lck 56 3
JNK2 60 3
CHK1 66 6
CSK 68 0
ROCK 2 72 13
JNK3 72 6
Src 72 3
PKD1 77 7
S6K1 79 5
NEK2a 80 5
AMPK 80 0
PIM3 81 4
PDK1 81 2
PIM1 82 4
MELK 82 8
PAK6 82 10
ERK2 83 7
MAPKAP-K2 84 2
DYRK1A 84 0
Aurora B 85 1
MST2 85 5
BRSK2 85 11
HIPK2 85 6
MKK1 85 7
SmMLCK 85 1
PKC alpha 86 6
PAK4 86 12
CAMK1 86 5
PKC zeta 88 0
PAK5 88 0
ERK1 88 0
PKB alpha 89 11
PKB beta 89 0
PKA 89 3
MSK1 90 10
SRPK1 90 2
SGK1 90 0
CHK2 91 4
Aurora C 92 0
ERK8 93 8
RSK2 93 6
IKK beta 94 2
JNK1 95 0
PRK2 95 7
NEK7 95 6
PRAK 95 5
HIPK3 96 1
DYRK2 96 1
PIM2 97 2
EF2K 97 0
CK2 97 2
NEK6 98 0
MARK3 98 1
CAMKK beta 98 4
CDK2-Cyclin A 103 2
p38 gamma MAPK 104 0
PHK 104 2
CAMKK alpha 105 13
p38 delta MAPK 106 3
MNK2 106 1
PLK1 108 0
MNK1 108 10
DYRK3 112 0
MAPKAP-K3 119 5

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