Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SB-203580 C21H16N3OSF 377.4 p38 MAPK Powell D.J. (2003) Mol. Cell Biol. 23 7794 Davies S.P. (2000) Biochem. J. 351 95 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 7
ERK1 88 0
ERK2 83 7
JNK1 95 0
JNK2 60 3
JNK3 72 6
p38 alpha MAPK 9 0
p38 beta MAPK 12 0
p38 gamma MAPK 104 0
p38 delta MAPK 106 3
ERK8 93 8
RSK1 52 7
RSK2 93 6
PDK1 81 2
PKB alpha 89 11
PKB beta 89 0
SGK1 90 0
S6K1 79 5
PKA 89 3
ROCK 2 72 13
PRK2 95 7
PKC alpha 86 6
PKC zeta 88 0
PKD1 77 7
MSK1 90 10
MNK1 108 10
MNK2 106 1
MAPKAP-K2 84 2
MAPKAP-K3 119 5
PRAK 95 5
CAMKK alpha 105 13
CAMKK beta 98 4
CAMK1 86 5
SmMLCK 85 1
PHK 104 2
CHK1 66 6
CHK2 91 4
GSK3 beta 34 2
CDK2-Cyclin A 103 2
PLK1 108 0
Aurora B 85 1
Aurora C 92 0
AMPK 80 0
MARK3 98 1
BRSK2 85 11
MELK 82 8
CK1 delta 8 0
CK2 97 2
DYRK1A 84 0
DYRK2 96 1
DYRK3 112 0
NEK2a 80 5
NEK6 98 0
NEK7 95 6
IKK beta 94 2
PIM1 82 4
PIM2 97 2
PIM3 81 4
SRPK1 90 2
EF2K 97 0
HIPK2 85 6
HIPK3 96 1
PAK4 86 12
PAK5 88 0
PAK6 82 10
MST2 85 5
Src 72 3
Lck 56 3
CSK 68 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 4
ERK1 82 1
ERK2 85 1
JNK1 77 5
JNK2 16 0
JNK3 29 0
p38 alpha MAPK 2 0
p38 beta MAPK 3 1
p38 gamma MAPK 83 4
p38 delta MAPK 83 3
ERK8 80 8
RSK1 34 6
RSK2 60 7
PDK1 67 2
PKB alpha 77 7
PKB beta 80 4
SGK1 66 1
S6K1 78 4
PKA 53 4
ROCK 2 65 1
PRK2 67 1
PKC alpha 42 0
PKC zeta 65 8
PKD1 60 3
MSK1 78 5
MNK1 63 0
MNK2 92 1
MAPKAP-K2 111 4
MAPKAP-K3 88 8
PRAK 64 6
CAMKK alpha 72 4
CAMKK beta 78 0
CAMK1 79 4
SmMLCK 73 3
PHK 62 2
CHK1 67 3
CHK2 107 5
GSK3 beta 12 2
CDK2-Cyclin A 81 2
PLK1 83 6
Aurora B 63 4
Aurora C 68 4
AMPK 20 3
MARK3 66 3
BRSK2 58 4
MELK 53 0
CK1 delta 0 0
CK2 89 3
DYRK1A 91 1
DYRK2 88 8
DYRK3 75 5
NEK2a 83 2
NEK6 85 1
NEK7 108 3
IKK beta 87 4
PIM1 81 0
PIM2 106 8
PIM3 54 3
SRPK1 81 7
EF2K 101 1
HIPK2 90 1
HIPK3 99 7
PAK4 80 6
PAK5 88 4
PAK6 82 1
MST2 75 6
Src 47 5
Lck 24 4
CSK 37 2

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