Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Rottlerin C30H28O8 516.5 PKC Villalba M. (1999) J. Immunol. 163 5813 Gschwendt M. (1994) Biochem. Biophys. Res. Commun. 199 93 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
20µM

Results as Table

Screening Concentration: 20µM
Kinase % Activity Remaining Standard Deviation
MKK1 82 8
ERK1 105 1
ERK2 97 2
JNK1 22 4
JNK2 69 0
JNK3 52 0
p38 alpha MAPK 118 0
p38 beta MAPK 127 1
p38 gamma MAPK 122 1
p38 delta MAPK 80 1
ERK8 91 2
RSK1 16 2
RSK2 23 1
PDK1 62 5
PKB alpha 93 5
PKB beta 11 5
SGK1 22 5
S6K1 33 0
PKA 3 1
ROCK 2 75 1
PRK2 93 1
PKC alpha 64 0
PKC zeta 92 3
PKD1 63 3
MSK1 53 1
MNK1 75 0
MNK2 100 4
MAPKAP-K2 8 4
MAPKAP-K3 4 0
PRAK 0 0
CAMKK alpha 55 2
CAMKK beta 27 3
CAMK1 37 1
SmMLCK 15 3
PHK 72 2
CHK1 133 1
CHK2 6 0
GSK3 beta 33 3
CDK2-Cyclin A 87 2
PLK1 20 8
Aurora B 51 3
Aurora C 42 4
AMPK 54 2
MARK3 102 0
BRSK2 25 7
MELK 38 4
CK1 delta 94 8
CK2 91 1
DYRK1A 13 2
DYRK2 16 6
DYRK3 5 0
NEK2a 89 2
NEK6 87 4
NEK7 110 2
IKK beta 13 2
PIM1 23 1
PIM2 68 3
PIM3 3 0
SRPK1 9 1
EF2K 74 7
HIPK2 72 8
HIPK3 79 8
PAK4 19 1
PAK5 65 0
PAK6 67 5
MST2 51 3
Src 97 8
Lck 77 4
CSK 73 3
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 74 7
ERK1 96 6
ERK2 77 10
JNK1 80 5
JNK2 84 6
JNK3 74 0
p38 alpha MAPK 93 1
p38 beta MAPK 118 7
p38 gamma MAPK 94 4
p38 delta MAPK 86 7
ERK8 77 3
RSK1 74 5
RSK2 52 5
PDK1 80 1
PKB alpha 76 3
PKB beta 48 0
SGK1 72 7
S6K1 85 3
PKA 64 11
ROCK 2 91 5
PRK2 83 4
PKC alpha 59 7
PKC zeta 107 10
PKD1 79 7
MSK1 75 1
MNK1 77 0
MNK2 84 3
MAPKAP-K2 34 12
MAPKAP-K3 82 5
PRAK 41 9
CAMKK beta 42 8
CAMK1 93 7
SmMLCK 24 9
PHK 74 6
CHK1 105 6
CHK2 11 2
GSK3 beta 94 11
CDK2-Cyclin A 93 9
PLK1 40 11
Aurora B 45 0
Aurora C 50 3
AMPK 93 4
MARK3 94 2
BRSK2 94 6
MELK 60 4
CK1 delta 83 6
CK2 91 8
DYRK1A 96 5
DYRK2 96 2
DYRK3 31 4
NEK2a 104 5
NEK6 96 12
NEK7 96 9
IKK beta 77 0
IKK epsilon 71 12
TBK1 82 1
PIM1 63 3
PIM2 93 3
PIM3 14 0
SRPK1 6 2
EF2K 92 11
HIPK2 80 12
HIPK3 93 6
PAK4 53 7
PAK5 84 0
PAK6 120 8
MST2 73 6
MST4 87 9
Src 63 7
Lck 84 14
CSK 99 12
YES1 42 5
SYK 66 0
EPH-A2 71 11
FGF-R1 57 0
IRR 101 9

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