Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Roscovitine C19H26N6O 354.5 CDK De Azevedo W.F. (1997) Eur. J. Biochem. 243 518 Meijer L. (1997) Eur. J. Biochem. 243 527 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 81 5
ERK1 82 2
ERK2 83 2
JNK1 89 5
JNK2 88 6
JNK3 87 2
p38 alpha MAPK 96 4
p38 beta MAPK 94 3
p38 gamma MAPK 99 2
p38 delta MAPK 92 7
ERK8 40 5
RSK1 97 2
RSK2 71 3
PDK1 80 8
PKB alpha 100 3
PKB beta 83 4
SGK1 75 2
S6K1 90 5
PKA 73 1
ROCK 2 90 4
PRK2 89 2
PKC alpha 89 2
PKC zeta 82 6
PKD1 90 4
MSK1 78 1
MNK1 90 8
MNK2 97 2
MAPKAP-K2 97 7
MAPKAP-K3 86 5
PRAK 83 4
CAMKK alpha 73 5
CAMKK beta 71 5
CAMK1 104 3
SmMLCK 84 3
PHK 93 1
CHK1 87 5
CHK2 93 4
GSK3 beta 76 6
CDK2-Cyclin A 4 0
PLK1 91 1
Aurora B 94 6
Aurora C 96 4
AMPK 91 2
MARK3 87 5
BRSK2 79 4
MELK 88 7
CK1 delta 76 1
CK2 92 7
DYRK1A 87 5
DYRK2 90 4
DYRK3 97 2
NEK2a 85 6
NEK6 92 4
NEK7 87 5
IKK beta 80 3
PIM1 83 5
PIM2 106 4
PIM3 83 9
SRPK1 84 4
EF2K 85 8
HIPK2 84 5
HIPK3 90 1
PAK4 90 3
PAK5 74 3
PAK6 80 2
MST2 95 5
Src 89 2
Lck 76 2
CSK 88 4
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 61 1
ERK1 60 9
ERK2 41 7
JNK1 104 19
JNK2 105 1
p38 alpha MAPK 92 2
p38 beta MAPK 106 4
p38 gamma MAPK 109 0
p38 delta MAPK 88 14
ERK8 11 4
RSK1 66 5
RSK2 98 16
PDK1 116 14
PKB alpha 111 14
PKB beta 98 3
SGK1 92 4
S6K1 125 2
PKA 102 4
ROCK 2 110 8
PRK2 110 8
PKC alpha 160 53
PKC zeta 89 7
PKD1 103 3
MSK1 115 0
MNK1 105 21
MNK2 109 10
MAPKAP-K2 106 7
PRAK 102 2
CAMKK beta 46 0
CAMK1 96 5
SmMLCK 78 1
PHK 99 8
CHK1 103 9
CHK2 67 15
GSK3 beta 102 1
CDK2-Cyclin A 3 1
PLK1 73 4
Aurora B 110 8
AMPK 109 4
MARK3 102 0
BRSK2 103 24
MELK 70 11
CK1 delta 30 1
CK2 102 0
DYRK1A 13 0
DYRK2 81 4
DYRK3 99 2
NEK2a 96 2
NEK6 105 5
IKK beta 100 14
IKK epsilon 104 2
TBK1 97 7
PIM1 103 4
PIM2 99 5
PIM3 103 3
SRPK1 51 1
EF2K 111 4
HIPK2 99 9
PAK4 40 2
PAK5 56 5
PAK6 84 2
MST2 103 7
MST4 100 3
Src 97 6
Lck 125 5
CSK 103 5
YES1 103 12
BTK 90 9
SYK 113 6
EPH-A2 97 3
EPH-B3 91 7
FGF-R1 96 6
IGF-1R 60 5
IR 42 3
IRR 40 0
VEGFR1 95 4

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