Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
RO-31-8220 C25H23N5O2S • CH4O3S 553.7 PKC Trapp J. (2006) J. Med. Chem. 49 7307-16 Powell D.J. (2003) Mol. Cell Biol. 23 7794 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 7 0
MKK2 7 2
MKK6 60 1
ERK1 45 1
ERK2 59 2
JNK1 48 6
JNK2 48 5
JNK3 57 1
p38 alpha MAPK 58 6
p38 beta MAPK 68 1
p38 gamma MAPK 82 5
p38 delta MAPK 42 2
ERK8 3 1
RSK1 2 1
RSK2 1 0
PDK1 10 0
PKB alpha 2 1
PKB beta 4 1
SGK1 2 1
S6K1 2 0
PKA 4 1
ROCK 2 23 2
PRK2 1 0
PKC alpha 1 1
PKC gamma 16 1
PKC zeta 3 0
PKD1 25 5
STK33 7 1
MSK1 0 0
MNK1 80 8
MNK2 86 6
MAPKAP-K2 50 8
MAPKAP-K3 63 1
PRAK 79 7
CAMKK beta 5 0
CAMK1 11 9
SmMLCK 3 0
PHK 4 1
DAPK1 6 0
CHK1 5 2
CHK2 6 1
GSK3 beta 1 0
CDK2-Cyclin A 3 1
PLK1 94 10
Aurora A 65 1
Aurora B 24 5
LKB1 36 5
AMPK 17 4
MARK1 44 3
MARK2 11 2
MARK3 16 4
MARK4 29 0
BRSK1 24 1
BRSK2 15 0
MELK 25 3
NUAK1 4 0
CK1 delta 98 1
CK2 80 8
DYRK1A 3 2
DYRK2 62 4
DYRK3 3 0
NEK2a 83 1
NEK6 75 11
IKK beta 56 0
IKK epsilon 30 2
TBK1 6 1
PIM1 4 0
PIM2 4 0
PIM3 1 0
SRPK1 6 1
EF2K 88 10
HIPK1 8 0
HIPK2 8 0
HIPK3 15 0
CLK2 0 0
PAK2 43 7
PAK4 19 2
PAK5 30 1
PAK6 46 9
MST2 8 2
MST4 15 9
GCK 4 0
MINK1 3 0
MEKK1 79 5
MLK1 14 1
MLK3 3 0
TAO1 7 2
ASK1 68 3
TAK1 8 3
IRAK4 16 2
RIPK2 70 6
TTK 16 1
MPSK1 90 7
Src 129 10
Lck 12 2
CSK 70 2
YES1 19 4
ABL 59 3
BTK 10 0
JAK2 16 1
SYK 23 1
ZAP70 83 12
TIE2 35 4
BRK 68 8
EPH-A2 20 1
EPH-A4 19 0
EPH-B1 52 27
EPH-B2 22 1
EPH-B3 63 0
EPH-B4 38 1
FGF-R1 13 5
HER4 15 3
IGF-1R 2 0
IR 52 15
IRR 19 5
TrkA 1 1
VEGFR1 2 0
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 28 0
MKK2 24 5
MKK6 74 2
ERK1 85 1
ERK2 88 8
JNK1 76 3
JNK2 79 6
JNK3 91 8
p38 alpha MAPK 85 8
p38 beta MAPK 92 4
p38 gamma MAPK 91 6
p38 delta MAPK 84 8
ERK8 3 1
RSK1 4 1
RSK2 1 0
PDK1 30 4
PKB alpha 13 1
PKB beta 13 1
SGK1 6 1
S6K1 2 0
PKA 21 1
ROCK 2 70 3
PRK2 3 1
PKC alpha 4 0
PKC gamma 39 2
PKC zeta 6 0
PKD1 38 5
STK33 10 2
MSK1 1 0
MNK1 94 4
MNK2 107 7
MAPKAP-K2 75 8
MAPKAP-K3 92 20
PRAK 92 0
CAMKK beta 13 1
CAMK1 38 6
SmMLCK 11 0
PHK 8 1
DAPK1 43 5
CHK1 12 3
CHK2 34 6
GSK3 beta 1 1
CDK2-Cyclin A 4 1
PLK1 95 13
Aurora A 93 2
Aurora B 31 4
LKB1 77 5
AMPK 39 13
MARK1 75 7
MARK2 61 23
MARK3 80 37
MARK4 72 3
BRSK1 38 1
BRSK2 37 8
MELK 42 10
NUAK1 19 1
CK1 delta 94 5
CK2 93 15
DYRK1A 4 1
DYRK2 86 8
DYRK3 18 1
NEK2a 85 4
NEK6 85 12
IKK beta 84 3
IKK epsilon 75 7
TBK1 28 2
PIM1 6 2
PIM2 14 3
PIM3 32 44
SRPK1 29 1
EF2K 79 5
HIPK1 23 2
HIPK2 14 1
HIPK3 47 5
CLK2 1 0
PAK2 84 13
PAK4 49 2
PAK5 75 5
PAK6 78 11
MST2 16 3
MST4 21 1
GCK 15 0
MINK1 9 1
MEKK1 84 13
MLK1 66 43
MLK3 7 1
TAO1 34 8
ASK1 90 1
TAK1 37 7
IRAK4 40 4
RIPK2 89 4
TTK 35 2
MPSK1 103 1
Src 89 5
Lck 56 6
CSK 95 8
YES1 41 10
ABL 88 0
BTK 40 3
JAK2 55 4
SYK 69 5
ZAP70 73 3
TIE2 89 7
BRK 84 8
EPH-A2 57 4
EPH-A4 53 3
EPH-B1 83 2
EPH-B2 57 1
EPH-B3 91 21
EPH-B4 74 4
FGF-R1 40 24
HER4 40 4
IGF-1R 41 3
IR 101 0
IRR 23 0
TrkA 7 1
VEGFR1 5 1
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 64 0
ERK1 91 1
ERK2 98 1
JNK1 98 2
JNK2 93 2
JNK3 113 0
p38 alpha MAPK 108 2
p38 beta MAPK 114 1
p38 gamma MAPK 100 6
p38 delta MAPK 91 1
ERK8 54 0
RSK1 11 5
RSK2 3 1
PDK1 53 2
PKB alpha 63 2
PKB beta 69 2
SGK1 47 0
S6K1 20 0
PKA 58 1
ROCK 2 95 5
PRK2 8 2
PKC alpha 3 0
PKC zeta 33 3
PKD1 77 5
MSK1 12 2
MNK1 89 2
MNK2 110 1
MAPKAP-K2 90 7
MAPKAP-K3 89 0
PRAK 80 9
CAMKK alpha 114 1
CAMKK beta 68 3
CAMK1 90 0
SmMLCK 51 0
PHK 43 3
CHK1 53 2
CHK2 107 2
GSK3 beta 4 0
CDK2-Cyclin A 3 0
PLK1 80 0
Aurora B 86 5
Aurora C 73 3
AMPK 26 8
MARK3 72 1
BRSK2 65 2
MELK 51 5
CK1 delta 93 6
CK2 99 5
DYRK1A 36 1
DYRK2 90 1
DYRK3 63 7
NEK2a 87 1
NEK6 106 5
NEK7 108 2
IKK beta 91 3
PIM1 45 7
PIM2 30 1
PIM3 11 0
SRPK1 80 7
EF2K 115 1
HIPK2 47 7
HIPK3 86 8
PAK4 83 1
PAK5 74 6
PAK6 84 0
MST2 21 4
Src 92 6
Lck 64 1
CSK 75 5

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