Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Purvalanol A C19H25ClN6O 388.9 cyclin-dependent kinases Gray N.S. (1998) Science 281 533 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 115 3
MKK2 108 5
MKK6 94 3
ERK1 121 14
ERK2 98 11
JNK1 104 3
JNK2 89 4
JNK3 108 1
p38 alpha MAPK 99 3
p38 beta MAPK 105 10
p38 gamma MAPK 98 13
p38 delta MAPK 99 10
ERK8 59 1
RSK1 98 13
RSK2 97 13
PDK1 118 6
PKB alpha 125 14
PKB beta 105 15
SGK1 89 1
S6K1 106 12
PKA 107 2
ROCK 2 101 5
PRK2 81 9
PKC alpha 100 1
PKC gamma 97 1
PKC zeta 105 2
PKD1 118 14
STK33 99 13
MSK1 113 11
MNK1 92 5
MNK2 98 1
MAPKAP-K2 98 15
MAPKAP-K3 119 10
PRAK 118 14
CAMKK beta 60 2
CAMK1 113 10
SmMLCK 106 3
PHK 99 0
DAPK1 106 7
CHK1 103 1
CHK2 90 8
GSK3 beta 109 8
CDK2-Cyclin A 10 1
PLK1 94 1
Aurora A 125 9
Aurora B 116 9
LKB1 92 9
AMPK 101 6
MARK1 106 1
MARK2 96 3
MARK3 101 15
MARK4 118 7
BRSK1 100 0
BRSK2 76 6
MELK 72 3
NUAK1 106 0
CK1 delta 91 10
CK2 92 0
DYRK1A 79 3
DYRK2 117 3
DYRK3 94 6
NEK2a 95 1
NEK6 107 1
IKK beta 101 0
IKK epsilon 91 13
TBK1 109 11
PIM1 97 4
PIM2 112 12
PIM3 119 12
SRPK1 80 5
EF2K 83 6
HIPK1 114 5
HIPK2 99 11
HIPK3 109 6
CLK2 17 4
PAK2 94 2
PAK4 34 2
PAK5 78 3
PAK6 107 1
MST2 77 0
MST4 91 13
GCK 83 9
MINK1 104 10
MEKK1 80 5
MLK1 51 1
MLK3 65 9
TAO1 118 8
ASK1 112 2
TAK1 61 9
IRAK4 60 5
RIPK2 110 5
TTK 102 5
MPSK1 112 9
Src 19 1
Lck 95 10
CSK 97 7
YES1 34 6
ABL 95 5
BTK 66 7
JAK2 95 14
SYK 118 4
ZAP70 131 4
TIE2 164 21
BRK 133 8
EPH-A2 119 14
EPH-A4 122 2
EPH-B1 127 3
EPH-B2 100 1
EPH-B3 100 0
EPH-B4 101 1
FGF-R1 118 6
HER4 123 10
IGF-1R 71 7
IR 106 18
IRR 73 12
TrkA 45 4
VEGFR1 81 6
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 93 24
MKK2 108 8
MKK6 101 23
ERK1 87 5
ERK2 57 2
JNK1 90 9
JNK2 88 2
JNK3 92 2
p38 alpha MAPK 86 10
p38 beta MAPK 109 6
p38 gamma MAPK 87 10
p38 delta MAPK 97 1
ERK8 11 0
RSK1 47 7
RSK2 59 2
PDK1 110 2
PKB alpha 116 10
PKB beta 91 14
SGK1 76 15
S6K1 110 0
PKA 105 1
ROCK 2 101 3
PRK2 70 9
PKC alpha 98 4
PKC gamma 91 4
PKC zeta 98 6
PKD1 121 2
STK33 62 7
MSK1 110 9
MNK1 94 11
MNK2 112 1
MAPKAP-K2 94 14
MAPKAP-K3 116 1
PRAK 65 2
CAMKK beta 21 5
CAMK1 96 2
SmMLCK 36 1
PHK 79 1
DAPK1 104 12
CHK1 90 1
CHK2 64 12
GSK3 beta 71 7
CDK2-Cyclin A 3 0
PLK1 108 10
Aurora A 100 5
Aurora B 95 9
LKB1 60 3
AMPK 93 6
MARK1 90 6
MARK2 89 5
MARK3 73 6
MARK4 78 2
BRSK1 76 1
BRSK2 107 6
MELK 57 0
NUAK1 60 2
CK1 delta 78 1
CK2 72 11
DYRK1A 24 1
DYRK2 103 1
DYRK3 82 10
NEK2a 94 12
NEK6 90 3
IKK beta 84 10
IKK epsilon 99 23
TBK1 97 7
PIM1 87 9
PIM2 98 0
PIM3 93 13
SRPK1 32 0
EF2K 87 7
HIPK1 85 15
HIPK2 52 2
HIPK3 119 6
CLK2 4 1
PAK2 95 6
PAK4 8 1
PAK5 29 1
PAK6 59 3
MST2 28 2
MST4 48 0
GCK 40 2
MINK1 80 1
MEKK1 36 7
MLK1 7 0
MLK3 11 0
TAO1 70 5
ASK1 100 1
TAK1 19 1
IRAK4 21 0
RIPK2 111 3
TTK 53 3
MPSK1 100 2
Src 2 1
Lck 35 3
CSK 89 13
YES1 9 1
ABL 41 8
BTK 33 3
JAK2 73 3
SYK 109 14
ZAP70 119 6
TIE2 120 12
BRK 111 2
EPH-A2 66 7
EPH-A4 45 9
EPH-B1 83 8
EPH-B2 30 2
EPH-B3 63 1
EPH-B4 37 15
FGF-R1 69 5
HER4 109 20
IGF-1R 38 11
IR 53 15
IRR 34 3
TrkA 13 1
VEGFR1 70 1

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