Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Princeton's TrkA inhibitor compound 20h C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639 Download

Results as Barchart

View results as a bar chart
10µM
0.1µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 40 2
ERK1 99 1
ERK2 85 8
JNK1 53 9
JNK2 54 5
JNK3 54 3
p38 alpha MAPK 47 5
p38 beta MAPK 48 7
p38 gamma MAPK 45 5
p38 delta MAPK 5 1
ERK8 1 0
RSK1 6 0
RSK2 18 7
PDK1 106 8
PKB alpha 53 1
PKB beta 46 1
SGK1 41 8
S6K1 11 6
PKA 54 2
ROCK 2 63 5
PRK2 32 2
PKC alpha 11 2
PKC zeta 58 4
PKD1 45 5
MSK1 22 5
MNK1 77 13
MNK2 73 3
MAPKAP-K2 80 0
MAPKAP-K3 85 7
PRAK 96 9
CAMKK beta 19 2
CAMK1 11 0
SmMLCK 5 0
PHK 2 0
DAPK1 63 5
CHK1 52 6
CHK2 4 1
GSK3 beta 37 3
CDK2-Cyclin A 3 1
PLK1 114 3
Aurora A 0 0
Aurora B 7 1
LKB1 8 1
AMPK 3 1
MARK1 58 1
MARK2 44 3
MARK3 57 2
MARK4 43 3
BRSK1 41 11
BRSK2 40 1
MELK 5 2
NUAK1 7 0
CK1 delta 68 8
CK2 85 1
DYRK1A 61 3
DYRK2 80 3
DYRK3 43 1
NEK2a 71 4
NEK6 85 10
IKK beta 84 7
IKK epsilon 76 9
TBK1 93 1
PIM1 11 1
PIM2 77 11
PIM3 21 1
SRPK1 11 3
EF2K 92 10
HIPK1 5 1
HIPK2 5 0
HIPK3 17 1
CLK2 1 0
PAK2 16 2
PAK4 20 6
PAK5 22 0
PAK6 27 1
MST2 3 0
MST4 17 0
GCK 33 5
MINK1 8 1
MEKK1 5 1
MLK1 17 2
MLK3 51 0
TAK1 27 0
IRAK4 2 1
RIPK2 8 2
TTK 42 4
Src 2 0
Lck 5 3
CSK 9 1
YES1 6 0
BTK 8 0
JAK2 30 0
SYK 28 7
EPH-A2 13 2
EPH-A4 0 5
EPH-B2 4 0
EPH-B3 6 4
EPH-B4 4 1
FGF-R1 11 0
HER4 51 0
IGF-1R 2 1
IR 1 0
IRR 52 0
TrkA 4 1
VEGFR1 19 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 1
MKK2 77 7
MKK6 95 2
ERK1 78 6
ERK2 103 9
JNK1 99 4
JNK2 94 5
JNK3 107 0
p38 alpha MAPK 89 0
p38 beta MAPK 76 5
p38 gamma MAPK 80 6
p38 delta MAPK 24 2
ERK8 1 1
RSK1 29 1
RSK2 64 7
PDK1 98 5
PKB alpha 86 10
PKB beta 94 2
SGK1 90 1
S6K1 92 2
PKA 88 0
ROCK 2 82 3
PRK2 78 2
PKC alpha 45 7
PKC zeta 98 9
PKD1 85 1
MSK1 51 1
MNK1 103 13
MNK2 92 11
MAPKAP-K2 86 2
MAPKAP-K3 77 2
PRAK 94 1
CAMKK beta 19 2
CAMK1 59 9
SmMLCK 43 5
PHK 15 2
DAPK1 96 8
CHK1 53 10
CHK2 18 1
GSK3 beta 41 3
CDK2-Cyclin A 15 4
PLK1 85 1
Aurora A 3 0
Aurora B 42 7
LKB1 62 4
AMPK 47 2
MARK1 78 9
MARK2 87 5
MARK3 89 1
MARK4 118 13
BRSK1 81 9
BRSK2 80 3
MELK 15 5
NUAK1 37 5
CK1 delta 87 2
CK2 104 7
DYRK1A 101 5
DYRK2 87 7
DYRK3 78 4
NEK2a 87 1
NEK6 101 3
IKK beta 92 3
IKK epsilon 80 8
TBK1 78 4
PIM1 49 1
PIM2 92 1
PIM3 72 4
SRPK1 59 6
EF2K 96 10
HIPK1 42 2
HIPK2 13 0
HIPK3 31 3
CLK2 3 0
PAK2 44 1
PAK4 67 5
PAK5 58 3
PAK6 72 5
MST2 19 0
MST4 50 1
GCK 93 2
MINK1 64 4
MEKK1 35 0
MLK1 69 4
MLK3 77 12
TAO1 33 1
ASK1 101 12
TAK1 84 7
IRAK4 3 0
RIPK2 17 0
TTK 73 9
Src 20 3
Lck 13 1
CSK 88 12
YES1 11 1
BTK 53 3
JAK2 80 8
SYK 64 2
EPH-A2 36 7
EPH-A4 29 13
EPH-B1 36 5
EPH-B2 4 7
EPH-B3 20 4
EPH-B4 13 0
FGF-R1 43 3
HER4 64 15
IGF-1R 2 0
IR 14 3
IRR 80 15
TrkA 19 8
VEGFR1 52 11
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 2
MKK2 86 7
MKK6 94 14
ERK1 103 9
ERK2 99 6
JNK1 98 8
JNK2 98 1
JNK3 94 4
p38 alpha MAPK 101 9
p38 beta MAPK 87 1
p38 gamma MAPK 77 2
p38 delta MAPK 97 4
ERK8 1 0
RSK1 31 1
RSK2 67 1
PDK1 105 0
PKB alpha 105 3
PKB beta 80 8
SGK1 89 4
S6K1 95 6
PKA 98 7
ROCK 2 90 0
PRK2 80 13
PKC alpha 41 1
PKC zeta 104 4
PKD1 89 3
MSK1 59 3
MNK1 97 9
MNK2 120 5
MAPKAP-K2 98 4
MAPKAP-K3 91 6
PRAK 96 3
CAMKK beta 22 0
CAMK1 62 9
SmMLCK 51 6
PHK 43 0
DAPK1 99 5
CHK1 54 1
CHK2 20 1
GSK3 beta 46 1
CDK2-Cyclin A 35 2
PLK1 97 2
Aurora A 3 0
Aurora B 65 0
LKB1 64 4
AMPK 63 5
MARK1 70 11
MARK2 81 10
MARK3 103 8
MARK4 101 8
BRSK1 82 13
BRSK2 88 5
MELK 42 9
NUAK1 40 4
CK1 delta 99 6
CK2 119 11
DYRK1A 103 8
DYRK2 101 9
DYRK3 89 11
NEK2a 108 2
NEK6 103 5
IKK beta 107 3
IKK epsilon 91 3
TBK1 87 3
PIM1 54 7
PIM2 94 1
PIM3 53 13
SRPK1 71 12
EF2K 113 8
HIPK1 45 2
HIPK2 14 2
HIPK3 30 2
CLK2 3 0
PAK2 44 6
PAK4 69 5
PAK5 62 3
PAK6 71 12
MST2 16 0
MST4 50 0
GCK 101 4
MINK1 69 12
MEKK1 46 1
MLK1 78 4
MLK3 84 3
TAO1 42 5
ASK1 106 1
TAK1 107 3
IRAK4 5 2
RIPK2 20 0
TTK 75 2
Src 22 3
Lck 43 9
CSK 103 12
YES1 11 2
BTK 96 1
JAK2 84 9
SYK 82 14
EPH-A2 46 13
EPH-A4 22 6
EPH-B1 53 0
EPH-B2 11 1
EPH-B3 22 3
EPH-B4 15 1
FGF-R1 47 4
HER4 69 8
IGF-1R 2 0
IR 19 3
IRR 69 9
TrkA 14 1
VEGFR1 56 15

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