Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PP2 C15H16ClN5 301.77 Src Kirihara T. (2013) Exp Eye Res. S0014 WO2006068760 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 25 4
MKK2 37 2
MKK6 85 2
ERK1 75 10
ERK2 84 2
JNK1 101 12
JNK2 81 1
JNK3 66 10
p38 alpha MAPK 25 0
p38 beta MAPK 25 3
p38 gamma MAPK 104 6
p38 delta MAPK 89 13
ERK8 71 5
RSK1 64 3
RSK2 77 12
PDK1 101 4
PKB alpha 96 2
PKB beta 91 13
SGK1 102 11
S6K1 80 9
PKA 28 1
ROCK 2 84 2
PRK2 92 8
PKC alpha 39 3
PKC zeta 95 2
PKD1 64 0
MSK1 42 2
MNK1 82 9
MNK2 73 3
MAPKAP-K2 99 3
MAPKAP-K3 80 10
PRAK 97 1
CAMKK beta 72 9
CAMK1 73 10
SmMLCK 49 2
PHK 97 3
DAPK1 87 3
CHK1 95 6
CHK2 75 10
GSK3 beta 105 2
CDK2-Cyclin A 101 5
PLK1 109 5
Aurora A 96 7
Aurora B 66 0
LKB1 89 3
AMPK 84 5
MARK1 115 1
MARK2 86 7
MARK3 77 5
MARK4 77 2
BRSK1 59 1
BRSK2 81 1
MELK 35 1
NUAK1 100 1
CK1 delta 14 2
CK2 98 6
DYRK1A 93 8
DYRK2 91 8
DYRK3 100 5
NEK2a 102 5
NEK6 95 1
IKK beta 85 10
IKK epsilon 92 1
TBK1 94 10
PIM1 105 3
PIM2 95 4
PIM3 97 5
SRPK1 108 2
EF2K 94 2
HIPK1 99 3
HIPK2 91 5
HIPK3 108 7
CLK2 59 9
PAK2 74 1
PAK4 74 12
PAK5 78 0
PAK6 96 1
MST2 71 6
MST4 59 2
GCK 71 9
MINK1 74 5
MEKK1 105 11
MLK1 83 3
MLK3 43 11
TAO1 99 7
ASK1 91 1
TAK1 77 7
IRAK4 70 6
RIPK2 8 1
TTK 91 5
Src 7 5
Lck 2 1
CSK 6 0
YES1 15 1
BTK 14 2
JAK2 81 4
SYK 96 4
EPH-A2 20 3
EPH-A4 7 1
EPH-B1 5 1
EPH-B2 10 0
EPH-B3 5 1
EPH-B4 6 0
FGF-R1 19 1
HER4 18 2
IGF-1R 72 2
IR 69 2
IRR 82 5
TrkA 40 8
VEGFR1 26 5
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 51 5
MKK2 81 13
MKK6 90 5
ERK1 82 6
ERK2 77 0
JNK1 101 1
JNK2 84 3
JNK3 71 2
p38 alpha MAPK 74 2
p38 beta MAPK 36 6
p38 gamma MAPK 93 10
p38 delta MAPK 79 2
ERK8 67 4
RSK1 81 6
RSK2 86 1
PDK1 91 1
PKB alpha 93 8
PKB beta 88 8
SGK1 109 0
S6K1 72 0
PKA 77 6
ROCK 2 72 12
PRK2 87 10
PKC alpha 70 5
PKC zeta 103 7
PKD1 85 7
MSK1 71 0
MNK1 88 5
MNK2 79 0
MAPKAP-K2 107 3
MAPKAP-K3 89 10
PRAK 91 9
CAMKK beta 82 6
CAMK1 87 10
SmMLCK 73 4
PHK 99 4
DAPK1 89 11
CHK1 88 11
CHK2 86 2
GSK3 beta 80 2
CDK2-Cyclin A 76 14
PLK1 101 4
Aurora A 105 8
Aurora B 84 9
LKB1 82 3
AMPK 82 6
MARK1 92 4
MARK2 95 0
MARK3 89 8
MARK4 93 7
BRSK1 84 13
BRSK2 78 7
MELK 68 7
NUAK1 91 1
CK1 delta 17 1
CK2 93 9
DYRK1A 94 7
DYRK2 104 3
DYRK3 88 5
NEK2a 98 7
NEK6 96 2
IKK beta 100 10
IKK epsilon 71 7
TBK1 96 7
PIM1 106 1
PIM2 101 1
PIM3 84 4
SRPK1 107 9
EF2K 68 8
HIPK1 84 2
HIPK2 87 15
HIPK3 92 6
CLK2 63 3
PAK2 89 1
PAK4 85 5
PAK5 97 5
PAK6 88 5
MST2 78 4
MST4 77 3
GCK 92 9
MINK1 74 6
MEKK1 92 5
MLK1 68 4
MLK3 87 13
TAO1 80 9
ASK1 101 12
TAK1 90 12
IRAK4 78 10
RIPK2 6 2
TTK 81 11
Src 8 3
Lck 6 1
CSK 21 1
YES1 17 8
BTK 16 2
JAK2 78 8
SYK 97 8
EPH-A2 28 4
EPH-A4 13 1
EPH-B1 25 1
EPH-B2 10 2
EPH-B3 8 0
EPH-B4 8 0
FGF-R1 32 1
HER4 24 1
IGF-1R 99 10
IR 84 13
IRR 84 9
TrkA 40 8
VEGFR1 34 3
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 0
ERK1 96 3
ERK2 102 0
JNK1 97 9
JNK2 91 2
p38 alpha MAPK 105 15
p38 beta MAPK 81 1
p38 gamma MAPK 91 25
p38 delta MAPK 91 17
ERK8 95 1
RSK1 102 4
RSK2 125 25
PDK1 93 7
PKB alpha 98 11
PKB beta 79 12
SGK1 105 6
S6K1 86 9
PKA 84 0
ROCK 2 82 5
PRK2 78 1
PKC alpha 97 0
PKC zeta 101 3
PKD1 87 6
MSK1 88 3
MNK1 98 2
MNK2 111 19
MAPKAP-K2 79 13
PRAK 106 6
CAMKK beta 75 11
CAMK1 102 7
SmMLCK 104 8
PHK 94 2
CHK1 91 0
CHK2 109 0
GSK3 beta 82 8
CDK2-Cyclin A 87 1
PLK1 93 3
AMPK 97 3
MARK3 96 13
BRSK2 94 6
MELK 87 6
CK1 delta 59 5
CK2 100 1
DYRK1A 93 1
DYRK2 92 8
DYRK3 95 8
NEK2a 89 5
NEK6 88 5
IKK beta 87 10
IKK epsilon 87 3
TBK1 76 11
PIM1 98 15
PIM2 97 2
PIM3 94 2
SRPK1 96 12
EF2K 96 3
HIPK2 105 20
PAK4 90 2
PAK5 94 10
PAK6 95 4
MST2 93 2
MST4 93 6
Src 17 0
Lck 30 0
CSK 67 7
YES1 11 0
BTK 9 2
SYK 105 3
EPH-A2 29 9
EPH-B3 23 12
FGF-R1 75 16
IGF-1R 97 9
IR 82 16
IRR 72 3
VEGFR1 88 3

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