Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PP1 C16H19N5 281.36 Src Hanke (1996) J.Biol.Chem. 271 695 Liu (1999) Chem.Biol. 6 671 WO2012109732 Enzo (Alexis) Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 67 5
ERK1 113 1
ERK2 94 2
JNK1 93 10
JNK2 85 4
JNK3 85 0
p38 alpha MAPK 43 2
p38 beta MAPK 38 2
p38 gamma MAPK 98 8
p38 delta MAPK 69 7
ERK8 94 2
RSK1 94 4
RSK2 99 1
PDK1 84 11
PKB alpha 95 0
PKB beta 97 11
SGK1 87 0
S6K1 42 5
PKA 52 3
ROCK 2 81 0
PRK2 84 3
PKC alpha 75 4
PKC zeta 93 7
PKD1 76 2
MSK1 72 12
MNK1 76 1
MNK2 97 1
MAPKAP-K2 101 1
MAPKAP-K3 98 3
PRAK 101 0
CAMKK alpha 91 16
CAMKK beta 96 3
CAMK1 90 3
SmMLCK 92 9
PHK 85 7
CHK1 90 6
CHK2 101 6
GSK3 beta 94 6
CDK2-Cyclin A 89 6
PLK1 83 6
Aurora B 73 1
Aurora C 47 5
AMPK 102 9
MARK3 128 5
BRSK2 90 8
MELK 58 1
CK1 delta 20 2
CK2 99 4
DYRK1A 97 6
DYRK2 85 1
DYRK3 92 2
NEK2a 85 1
NEK6 80 3
NEK7 116 2
IKK beta 79 14
IKK epsilon 72 2
TBK1 60 6
PIM1 89 8
PIM2 111 15
PIM3 91 10
SRPK1 93 4
EF2K 127 7
HIPK2 86 8
HIPK3 101 3
PAK4 92 7
PAK5 87 3
PAK6 96 2
MST2 70 3
MST4 78 5
Src 4 1
Lck 6 1
CSK 39 1
YES1 1 0
BTK 3 0
SYK 92 12
EPH-A2 11 2
EPH-B3 6 4
FGF-R1 19 1
IGF-1R 106 4
IR 103 2
IRR 67 20
VEGFR1 16 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 59 1
ERK1 104 6
ERK2 75 0
JNK1 92 0
JNK2 42 2
JNK3 50 0
p38 alpha MAPK 11 2
p38 beta MAPK 10 1
p38 gamma MAPK 88 1
p38 delta MAPK 87 8
ERK8 73 8
RSK1 49 6
RSK2 69 5
PDK1 82 5
PKB alpha 79 6
PKB beta 93 8
SGK1 84 0
S6K1 15 0
PKA 29 0
ROCK 2 43 3
PRK2 81 7
PKC alpha 52 2
PKC zeta 77 2
PKD1 41 9
MSK1 45 1
MNK1 50 6
MNK2 74 2
MAPKAP-K2 107 6
MAPKAP-K3 114 4
PRAK 77 8
CAMKK alpha 71 4
CAMKK beta 52 2
CAMK1 87 2
SmMLCK 76 0
PHK 67 1
CHK1 95 1
CHK2 55 4
GSK3 beta 100 1
CDK2-Cyclin A 58 0
PLK1 92 8
Aurora B 40 1
Aurora C 17 1
AMPK 107 1
MARK3 93 1
BRSK2 2 0
MELK 23 4
CK1 delta 4 0
CK2 100 7
DYRK1A 81 7
DYRK2 94 2
DYRK3 61 2
NEK2a 84 3
NEK6 111 8
NEK7 107 2
IKK beta 85 1
PIM1 97 1
PIM2 89 7
PIM3 79 2
SRPK1 82 5
EF2K 100 0
HIPK2 65 0
HIPK3 102 4
PAK4 63 2
PAK5 71 3
PAK6 90 0
MST2 34 2
Src 0 0
Lck 2 0
CSK 4 0
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 3
ERK1 82 0
ERK2 103 2
JNK1 95 11
JNK2 88 1
p38 alpha MAPK 78 3
p38 beta MAPK 89 4
p38 gamma MAPK 102 0
p38 delta MAPK 84 9
ERK8 88 2
RSK1 94 16
RSK2 91 6
PDK1 99 11
PKB alpha 95 1
PKB beta 127 42
SGK1 87 3
S6K1 86 14
PKA 86 2
ROCK 2 86 2
PRK2 108 4
PKC alpha 95 15
PKC zeta 89 6
PKD1 89 9
MSK1 92 10
MNK1 93 3
MNK2 94 7
MAPKAP-K2 78 2
PRAK 102 11
CAMKK beta 84 4
CAMK1 102 3
SmMLCK 103 23
PHK 90 12
CHK1 90 4
CHK2 117 12
GSK3 beta 94 2
CDK2-Cyclin A 105 6
PLK1 88 6
AMPK 99 7
MARK3 93 5
BRSK2 93 15
MELK 87 0
CK1 delta 75 1
CK2 107 1
DYRK1A 88 3
DYRK2 91 8
DYRK3 98 12
NEK2a 100 8
NEK6 88 5
IKK beta 89 4
IKK epsilon 98 13
TBK1 78 0
PIM1 98 11
PIM2 103 5
PIM3 88 13
SRPK1 105 9
EF2K 97 18
HIPK2 99 5
PAK4 89 3
PAK5 98 17
PAK6 97 0
MST2 82 6
MST4 99 3
Src 17 0
Lck 33 0
CSK 68 1
YES1 10 0
BTK 12 4
SYK 96 5
EPH-A2 40 0
EPH-B3 30 8
FGF-R1 68 11
IGF-1R 102 8
IR 96 6
IRR 77 13
VEGFR1 67 5

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