Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PLX 4720 (Raf Kinase Inhibitor V) C17H14ClF2N3O3S 413.83 B-Raf Tsai J. (2008) Proc Natl Acad Sci USA. 3041-6 WO2011028540 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 45 1
MKK2 25 3
MKK6 94 10
ERK1 103 7
ERK2 90 6
JNK1 89 1
JNK2 88 6
JNK3 85 4
p38 alpha MAPK 58 6
p38 beta MAPK 57 2
p38 gamma MAPK 94 2
p38 delta MAPK 79 6
ERK8 42 3
RSK1 98 4
RSK2 80 3
PDK1 85 12
PKB alpha 101 6
PKB beta 78 15
SGK1 88 11
S6K1 84 1
PKA 104 1
ROCK 2 66 1
PRK2 89 12
PKC alpha 84 4
PKC zeta 93 7
PKD1 87 13
MSK1 91 3
MNK1 79 13
MNK2 98 10
MAPKAP-K2 100 7
MAPKAP-K3 89 2
PRAK 93 2
CAMKK beta 71 6
CAMK1 27 1
SmMLCK 36 1
PHK 110 1
DAPK1 83 13
CHK1 28 0
CHK2 77 0
GSK3 beta 53 3
CDK2-Cyclin A 102 3
PLK1 95 1
Aurora A 23 1
Aurora B 20 4
LKB1 64 4
AMPK 56 4
MARK1 70 0
MARK2 87 2
MARK3 74 0
MARK4 65 3
BRSK1 82 6
BRSK2 73 8
MELK 24 0
NUAK1 61 7
CK1 delta 96 4
CK2 77 3
DYRK1A 77 6
DYRK2 81 4
DYRK3 68 1
NEK2a 52 0
NEK6 114 13
IKK beta 71 3
IKK epsilon 81 10
TBK1 96 7
PIM1 68 5
PIM2 92 3
PIM3 61 3
SRPK1 79 3
EF2K 100 2
HIPK1 93 3
HIPK2 48 7
HIPK3 90 14
CLK2 20 2
PAK2 40 8
PAK4 46 1
PAK5 49 4
PAK6 79 2
MST2 40 1
MST4 66 4
GCK 26 2
MINK1 15 0
MEKK1 65 3
MLK1 34 4
MLK3 33 3
TAO1 63 3
ASK1 95 15
TAK1 92 9
IRAK4 87 4
RIPK2 7 1
TTK 75 11
Src 21 0
Lck 34 6
CSK 84 2
YES1 13 3
BTK 69 0
JAK2 45 1
SYK 96 14
EPH-A2 97 2
EPH-A4 96 3
EPH-B1 85 3
EPH-B2 76 1
EPH-B3 83 12
EPH-B4 97 0
FGF-R1 30 3
HER4 49 3
IGF-1R 80 3
IR 117 9
IRR 64 6
TrkA 54 4
VEGFR1 10 0
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 84 8
MKK2 79 2
MKK6 125 11
ERK1 116 0
ERK2 112 6
JNK1 106 3
JNK2 98 0
JNK3 75 7
p38 alpha MAPK 83 2
p38 beta MAPK 88 3
p38 gamma MAPK 108 5
p38 delta MAPK 92 9
ERK8 88 3
RSK1 92 2
RSK2 111 7
PDK1 94 0
PKB alpha 105 3
PKB beta 82 14
SGK1 103 4
S6K1 93 1
PKA 112 1
ROCK 2 91 3
PRK2 99 2
PKC alpha 104 7
PKC zeta 101 2
PKD1 93 15
MSK1 111 3
MNK1 107 7
MNK2 113 7
MAPKAP-K2 112 12
MAPKAP-K3 115 5
PRAK 93 5
CAMKK beta 98 7
CAMK1 84 2
SmMLCK 90 4
PHK 111 3
DAPK1 98 3
CHK1 81 5
CHK2 115 14
GSK3 beta 97 12
CDK2-Cyclin A 110 4
PLK1 126 4
Aurora A 84 0
Aurora B 71 8
LKB1 109 5
AMPK 114 2
MARK1 97 0
MARK2 93 3
MARK3 93 15
MARK4 98 1
BRSK1 97 3
BRSK2 107 10
MELK 116 10
NUAK1 83 6
CK1 delta 98 3
CK2 109 10
DYRK1A 99 10
DYRK2 106 2
DYRK3 98 6
NEK2a 98 8
NEK6 112 3
IKK beta 89 3
IKK epsilon 102 8
TBK1 102 3
PIM1 104 13
PIM2 102 1
PIM3 97 3
SRPK1 101 4
EF2K 122 11
HIPK1 109 1
HIPK2 95 3
HIPK3 104 4
CLK2 84 14
PAK2 83 5
PAK4 77 1
PAK5 108 2
PAK6 107 13
MST2 76 13
MST4 109 1
GCK 94 8
MINK1 105 13
MEKK1 96 2
MLK1 88 10
MLK3 84 7
TAO1 109 9
ASK1 100 7
TAK1 96 11
IRAK4 107 1
RIPK2 21 7
TTK 88 1
Src 62 3
Lck 58 8
CSK 59 2
YES1 43 2
BTK 116 12
JAK2 95 11
SYK 114 9
EPH-A2 105 2
EPH-A4 113 5
EPH-B1 94 0
EPH-B2 114 0
EPH-B3 126 13
EPH-B4 125 1
FGF-R1 80 14
HER4 96 0
IGF-1R 110 9
IR 116 0
IRR 95 11
TrkA 107 12
VEGFR1 49 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 116 28
ERK1 115 44
ERK2 81 17
JNK1 104 5
JNK2 90 9
p38 alpha MAPK 84 13
p38 beta MAPK 85 13
p38 gamma MAPK 95 8
p38 delta MAPK 106 8
ERK8 91 10
RSK1 105 0
RSK2 93 17
PDK1 96 1
PKB alpha 92 13
PKB beta 100 10
SGK1 88 9
S6K1 93 13
PKA 94 6
ROCK 2 99 1
PRK2 93 5
PKC alpha 96 2
PKC zeta 102 6
PKD1 97 2
MSK1 90 10
MNK1 82 6
MNK2 77 5
MAPKAP-K2 102 12
PRAK 98 11
CAMKK beta 92 1
CAMK1 107 13
SmMLCK 93 1
PHK 97 22
CHK1 87 6
CHK2 78 19
GSK3 beta 95 3
CDK2-Cyclin A 80 12
PLK1 94 0
Aurora B 86 0
AMPK 91 17
MARK3 92 8
BRSK2 109 4
MELK 81 7
CK1 delta 92 0
CK2 88 25
DYRK1A 96 2
DYRK2 87 16
DYRK3 97 4
NEK2a 84 13
NEK6 94 2
IKK beta 100 14
IKK epsilon 84 3
TBK1 94 9
PIM1 106 11
PIM2 115 13
PIM3 109 9
SRPK1 89 8
EF2K 97 6
HIPK2 92 8
PAK4 79 5
PAK5 119 8
PAK6 101 13
MST2 85 6
MST4 104 3
Src 71 4
Lck 77 7
CSK 95 18
YES1 74 4
BTK 102 4
SYK 98 1
EPH-A2 100 2
EPH-B3 105 18
FGF-R1 101 0
IGF-1R 90 3
IR 99 0
IRR 88 10
VEGFR1 87 3

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