Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Pirfenidone C12H11NO 185.23 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125 Iyer (1999) J.Pharmacol.Exp.Ther. 289 211 WO2005040758 Tocris Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 77 0
MKK2 58 4
MKK6 106 5
ERK1 125 13
ERK2 95 4
JNK1 85 2
JNK2 85 12
JNK3 83 1
p38 alpha MAPK 102 10
p38 beta MAPK 120 11
p38 gamma MAPK 109 3
p38 delta MAPK 97 10
ERK8 95 8
RSK1 107 4
RSK2 98 2
PDK1 97 9
PKB alpha 108 11
PKB beta 99 11
SGK1 113 4
S6K1 115 10
PKA 90 10
ROCK 2 94 8
PRK2 121 9
PKC alpha 99 20
PKC gamma 99 11
PKC zeta 109 5
PKD1 122 12
STK33 82 9
MSK1 98 5
MNK1 101 12
MNK2 90 2
MAPKAP-K2 108 5
MAPKAP-K3 92 4
PRAK 100 2
CAMKK beta 97 1
CAMK1 98 3
SmMLCK 102 8
PHK 103 0
DAPK1 112 3
CHK1 97 8
CHK2 119 7
GSK3 beta 102 2
CDK2-Cyclin A 103 5
PLK1 96 1
Aurora A 106 4
Aurora B 93 5
TLK1 113 6
LKB1 103 16
AMPK 99 5
MARK1 99 16
MARK2 104 7
MARK3 108 0
MARK4 98 25
BRSK1 95 10
BRSK2 106 0
MELK 94 4
NUAK1 115 1
TSSK1 87 11
CK1 delta 97 12
CK2 98 0
TTBK1 124 0
DYRK1A 103 1
DYRK2 107 2
DYRK3 103 9
NEK2a 107 9
NEK6 99 2
IKK beta 87 10
IKK epsilon 104 7
TBK1 99 14
PIM1 105 9
PIM2 118 8
PIM3 111 5
SRPK1 95 9
EF2K 83 2
EIF2AK3 106 9
HIPK1 118 3
HIPK2 122 2
HIPK3 100 12
CLK2 120 16
PAK2 101 7
PAK4 101 8
PAK5 88 4
PAK6 106 8
MST2 112 15
MST4 105 6
GCK 106 9
MINK1 106 1
MEKK1 106 6
MLK1 95 12
MLK3 108 16
TESK1 94 6
TAO1 118 4
ASK1 114 25
TAK1 103 21
IRAK1 105 6
IRAK4 83 4
RIPK2 86 11
OSR1 114 20
TTK 73 11
MPSK1 87 0
Src 123 11
Lck 96 18
CSK 98 1
YES1 118 8
ABL 106 5
BTK 119 4
JAK2 103 7
SYK 99 17
ZAP70 110 1
TIE2 110 4
BRK 101 5
EPH-A2 113 11
EPH-A4 106 9
EPH-B1 109 22
EPH-B2 120 19
EPH-B3 96 5
EPH-B4 112 9
FGF-R1 101 8
HER4 123 23
IGF-1R 105 5
IR 110 4
IRR 104 3
TrkA 103 14
VEGFR1 100 13
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 65 10
MKK2 35 8
MKK6 88 7
ERK1 115 6
ERK2 97 1
JNK1 87 3
JNK2 86 1
JNK3 86 11
p38 alpha MAPK 83 7
p38 beta MAPK 111 1
p38 gamma MAPK 96 8
p38 delta MAPK 91 2
ERK8 86 13
RSK1 114 1
RSK2 94 0
PDK1 95 3
PKB alpha 102 12
PKB beta 91 8
SGK1 100 4
S6K1 111 7
PKA 97 7
ROCK 2 84 6
PRK2 91 1
PKC alpha 118 9
PKC gamma 94 8
PKC zeta 97 13
PKD1 91 6
STK33 90 4
MSK1 95 3
MNK1 99 0
MNK2 93 7
MAPKAP-K2 93 2
MAPKAP-K3 84 9
PRAK 95 7
CAMKK beta 108 2
CAMK1 81 1
SmMLCK 89 0
PHK 96 6
DAPK1 100 16
CHK1 90 2
CHK2 97 0
GSK3 beta 99 0
CDK2-Cyclin A 97 0
PLK1 82 9
Aurora A 107 2
Aurora B 87 0
TLK1 115 1
LKB1 95 14
AMPK 103 2
MARK1 98 6
MARK2 102 1
MARK3 108 3
MARK4 74 3
BRSK1 93 4
BRSK2 96 3
MELK 98 10
NUAK1 100 6
TSSK1 91 16
CK1 delta 102 13
CK2 103 4
TTBK1 107 15
DYRK1A 91 15
DYRK2 98 3
DYRK3 93 5
NEK2a 95 8
NEK6 91 9
IKK beta 88 6
IKK epsilon 99 2
TBK1 91 0
PIM1 106 12
PIM2 96 7
PIM3 95 8
SRPK1 89 8
EF2K 87 6
EIF2AK3 105 3
HIPK1 103 4
HIPK2 106 14
HIPK3 96 6
CLK2 112 7
PAK2 100 6
PAK4 89 4
PAK5 96 2
PAK6 96 3
MST2 112 10
MST4 102 2
GCK 108 0
MINK1 108 3
MEKK1 103 0
MLK1 89 8
MLK3 98 5
TESK1 82 8
TAO1 100 5
ASK1 99 3
TAK1 119 35
IRAK1 93 27
IRAK4 95 0
RIPK2 87 7
OSR1 115 8
TTK 76 7
MPSK1 96 6
Src 102 5
Lck 102 12
CSK 87 1
YES1 109 2
ABL 112 15
BTK 115 10
JAK2 90 10
SYK 103 9
ZAP70 100 21
TIE2 118 18
BRK 92 16
EPH-A2 111 3
EPH-A4 99 9
EPH-B1 104 2
EPH-B2 109 3
EPH-B3 112 15
EPH-B4 120 8
FGF-R1 104 22
HER4 106 19
IGF-1R 102 1
IR 103 3
IRR 99 7
TrkA 112 3
VEGFR1 107 15

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