Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PI-103 C19H16N4O3 348.36 PI3K Samuels Y. (2004) Science 304 554 WO2001083456 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 68 5
ERK1 88 6
ERK2 96 4
JNK1 97 3
JNK2 93 4
JNK3 90 6
p38 alpha MAPK 91 5
p38 beta MAPK 85 5
p38 gamma MAPK 97 8
p38 delta MAPK 81 4
ERK8 74 3
RSK1 90 13
RSK2 104 9
PDK1 90 1
PKB alpha 74 2
PKB beta 76 5
SGK1 88 2
S6K1 81 7
PKA 73 6
ROCK 2 75 3
PRK2 80 8
PKC alpha 82 4
PKC zeta 76 2
PKD1 92 2
MSK1 96 1
MNK1 89 6
MNK2 103 11
MAPKAP-K2 99 17
MAPKAP-K3 88 15
PRAK 92 6
CAMKK alpha 88 7
CAMKK beta 79 5
CAMK1 108 7
SmMLCK 62 5
PHK 83 5
CHK1 94 5
CHK2 78 11
GSK3 beta 84 10
CDK2-Cyclin A 95 5
PLK1 79 10
Aurora B 83 1
Aurora C 103 3
AMPK 105 15
MARK3 99 6
BRSK2 96 0
MELK 79 8
CK1 delta 87 1
CK2 82 6
DYRK1A 87 5
DYRK2 81 7
DYRK3 79 8
NEK2a 114 2
NEK6 111 6
NEK7 106 1
IKK beta 95 4
PIM1 77 2
PIM2 106 7
PIM3 79 2
SRPK1 82 8
EF2K 110 13
HIPK2 67 0
HIPK3 75 6
PAK4 97 4
PAK5 90 8
PAK6 98 7
MST2 91 5
Src 90 7
Lck 89 2
CSK 82 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 69 3
ERK1 114 5
ERK2 90 4
JNK1 95 7
JNK2 81 6
JNK3 87 0
p38 alpha MAPK 86 0
p38 beta MAPK 97 3
p38 gamma MAPK 99 2
p38 delta MAPK 87 0
ERK8 45 6
RSK1 41 0
RSK2 51 5
PDK1 91 1
PKB alpha 65 0
PKB beta 79 2
SGK1 79 4
S6K1 86 2
PKA 77 1
ROCK 2 87 5
PRK2 55 4
PKC alpha 53 0
PKC zeta 79 4
PKD1 87 7
MSK1 83 1
MNK1 71 6
MNK2 84 1
MAPKAP-K2 110 5
MAPKAP-K3 97 7
PRAK 79 4
CAMKK alpha 78 5
CAMKK beta 72 1
CAMK1 73 1
SmMLCK 18 5
PHK 56 4
CHK1 85 0
CHK2 97 0
GSK3 beta 48 4
CDK2-Cyclin A 70 1
PLK1 86 1
Aurora B 81 1
Aurora C 73 4
AMPK 88 0
MARK3 77 2
BRSK2 63 1
MELK 55 2
CK1 delta 68 0
CK2 77 2
DYRK1A 64 1
DYRK2 72 1
DYRK3 21 4
NEK2a 77 9
NEK6 83 0
NEK7 104 4
IKK beta 79 0
PIM1 60 8
PIM2 77 4
PIM3 27 8
SRPK1 78 2
EF2K 108 4
HIPK2 60 0
HIPK3 68 0
PAK4 75 5
PAK5 86 3
PAK6 97 0
MST2 73 5
Src 82 8
Lck 62 1
CSK 74 2

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