Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PD 184352 (CI-1040) C17H14ClF2IN2O2 478.66 MEK1, Yes1, ERK1 Mayes PA. (2013) Int J Cancer. E149-57 WO1998037881 Axon Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
MKK1 12 1
PIM3 66 4
CAMK1 69 4
Aurora B 70 1
PKC zeta 72 0
PIM1 75 3
DYRK2 76 2
CAMKK alpha 77 1
GSK3 beta 78 6
PDK1 79 4
PKB beta 80 0
DYRK1A 80 2
CSK 81 2
MAPKAP-K2 81 5
PLK1 82 0
BRSK2 82 5
PRAK 82 1
MELK 82 3
PAK4 82 3
PRK2 83 1
ERK2 83 3
MAPKAP-K3 84 8
Lck 85 2
PKD1 85 3
ROCK 2 86 0
p38 alpha MAPK 86 7
ERK1 86 0
p38 gamma MAPK 87 3
PKB alpha 87 7
PKA 87 0
PKC alpha 88 2
CDK2-Cyclin A 88 8
MST2 89 1
S6K1 89 1
NEK6 90 6
CAMKK beta 90 1
CK2 90 10
Src 90 5
MSK1 91 5
JNK1 92 1
IKK beta 92 0
PIM2 92 1
MNK1 92 9
RSK2 92 4
NEK7 93 1
p38 delta MAPK 93 2
ERK8 94 2
SRPK1 94 4
CHK2 95 8
HIPK3 95 6
p38 beta MAPK 96 7
Aurora C 96 9
EF2K 97 0
NEK2a 98 1
MARK3 98 2
PAK5 98 9
PHK 98 2
MNK2 99 3
CK1 delta 100 1
PAK6 100 1
SGK1 101 6
DYRK3 104 2
SmMLCK 105 3
JNK3 108 4
AMPK 108 3
JNK2 110 4
CHK1 113 1
RSK1 124 11
HIPK2 151 5
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
MKK1 45 0
RSK1 48 5
PIM3 56 1
RSK2 58 6
MELK 64 2
PKC alpha 64 2
GSK3 beta 65 4
PKA 66 3
MST2 68 1
PRK2 69 4
PHK 70 2
Lck 70 2
PAK6 75 1
Aurora B 77 4
CSK 77 6
CDK2-Cyclin A 79 3
AMPK 80 4
MARK3 80 2
EF2K 80 1
MAPKAP-K3 81 5
PRAK 81 2
CAMK1 81 4
PKC zeta 81 6
Aurora C 82 4
PDK1 82 0
PAK5 82 7
ROCK 2 82 7
BRSK2 83 5
SGK1 84 3
CHK1 84 6
PIM1 84 8
SRPK1 85 0
MAPKAP-K2 85 3
HIPK2 85 5
DYRK1A 86 6
SmMLCK 86 7
NEK2a 86 0
p38 delta MAPK 87 1
CAMKK alpha 87 2
S6K1 87 1
MSK1 88 7
DYRK3 88 3
IKK beta 88 4
NEK6 89 2
CAMKK beta 90 1
PLK1 90 4
MNK1 92 4
PKB alpha 92 8
DYRK2 93 7
PIM2 94 2
HIPK3 94 9
JNK3 94 0
PAK4 95 1
JNK2 95 3
p38 gamma MAPK 96 1
CK1 delta 99 5
Src 100 1
PKD1 100 1
MNK2 101 4
JNK1 101 4
CK2 102 0
ERK2 102 5
PKB beta 103 1
p38 beta MAPK 104 5
ERK1 106 6
ERK8 107 2
p38 alpha MAPK 109 3
CHK2 110 4
NEK7 110 4

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