Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PD 184352 (CI-1040) C17H14ClF2IN2O2 478.66 MEK1, Yes1, ERK1 Mayes PA. (2013) Int J Cancer. E149-57 WO1998037881 Axon Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 45 0
ERK1 106 6
ERK2 102 5
JNK1 101 4
JNK2 95 3
JNK3 94 0
p38 alpha MAPK 109 3
p38 beta MAPK 104 5
p38 gamma MAPK 96 1
p38 delta MAPK 87 1
ERK8 107 2
RSK1 48 5
RSK2 58 6
PDK1 82 0
PKB alpha 92 8
PKB beta 103 1
SGK1 84 3
S6K1 87 1
PKA 66 3
ROCK 2 82 7
PRK2 69 4
PKC alpha 64 2
PKC zeta 81 6
PKD1 100 1
MSK1 88 7
MNK1 92 4
MNK2 101 4
MAPKAP-K2 85 3
MAPKAP-K3 81 5
PRAK 81 2
CAMKK alpha 87 2
CAMKK beta 90 1
CAMK1 81 4
SmMLCK 86 7
PHK 70 2
CHK1 84 6
CHK2 110 4
GSK3 beta 65 4
CDK2-Cyclin A 79 3
PLK1 90 4
Aurora B 77 4
Aurora C 82 4
AMPK 80 4
MARK3 80 2
BRSK2 83 5
MELK 64 2
CK1 delta 99 5
CK2 102 0
DYRK1A 86 6
DYRK2 93 7
DYRK3 88 3
NEK2a 86 0
NEK6 89 2
NEK7 110 4
IKK beta 88 4
PIM1 84 8
PIM2 94 2
PIM3 56 1
SRPK1 85 0
EF2K 80 1
HIPK2 85 5
HIPK3 94 9
PAK4 95 1
PAK5 82 7
PAK6 75 1
MST2 68 1
Src 100 1
Lck 70 2
CSK 77 6
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 12 1
ERK1 86 0
ERK2 83 3
JNK1 92 1
JNK2 110 4
JNK3 108 4
p38 alpha MAPK 86 7
p38 beta MAPK 96 7
p38 gamma MAPK 87 3
p38 delta MAPK 93 2
ERK8 94 2
RSK1 124 11
RSK2 92 4
PDK1 79 4
PKB alpha 87 7
PKB beta 80 0
SGK1 101 6
S6K1 89 1
PKA 87 0
ROCK 2 86 0
PRK2 83 1
PKC alpha 88 2
PKC zeta 72 0
PKD1 85 3
MSK1 91 5
MNK1 92 9
MNK2 99 3
MAPKAP-K2 81 5
MAPKAP-K3 84 8
PRAK 82 1
CAMKK alpha 77 1
CAMKK beta 90 1
CAMK1 69 4
SmMLCK 105 3
PHK 98 2
CHK1 113 1
CHK2 95 8
GSK3 beta 78 6
CDK2-Cyclin A 88 8
PLK1 82 0
Aurora B 70 1
Aurora C 96 9
AMPK 108 3
MARK3 98 2
BRSK2 82 5
MELK 82 3
CK1 delta 100 1
CK2 90 10
DYRK1A 80 2
DYRK2 76 2
DYRK3 104 2
NEK2a 98 1
NEK6 90 6
NEK7 93 1
IKK beta 92 0
PIM1 75 3
PIM2 92 1
PIM3 66 4
SRPK1 94 4
EF2K 97 0
HIPK2 151 5
HIPK3 95 6
PAK4 82 3
PAK5 98 9
PAK6 100 1
MST2 89 1
Src 90 5
Lck 85 2
CSK 81 2

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