Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GW441756 hydrochloride C17H13N3O • HCl 311.77 Trk A Wood E.R. (2004) Bioorg. Med. Chem. Lett. 14 953-957 Sigma Download

Results as Barchart

View results as a bar chart
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 67 1
MKK2 42 4
MKK6 102 2
ERK1 90 1
ERK2 109 7
JNK1 112 0
JNK2 106 8
JNK3 96 2
p38 alpha MAPK 102 1
p38 beta MAPK 103 13
p38 gamma MAPK 106 10
p38 delta MAPK 99 4
ERK8 64 4
RSK1 51 4
RSK2 66 4
PDK1 88 2
PKB alpha 88 9
PKB beta 96 11
SGK1 92 2
S6K1 76 13
PKA 117 15
ROCK 2 62 7
PRK2 88 13
PKC alpha 109 10
PKC gamma 96 29
PKC zeta 97 12
PKD1 72 3
STK33 73 17
MSK1 85 14
MNK1 88 2
MNK2 67 10
MAPKAP-K2 73 12
MAPKAP-K3 78 4
PRAK 99 3
CAMKK beta 63 2
CAMK1 94 6
SmMLCK 74 3
PHK 57 3
DAPK1 83 3
CHK1 84 4
CHK2 34 4
GSK3 beta 63 17
CDK2-Cyclin A 116 9
PLK1 104 10
Aurora A 42 10
Aurora B 74 4
TLK1 112 11
LKB1 100 8
AMPK 97 4
MARK1 82 7
MARK2 108 25
MARK3 81 1
MARK4 81 14
BRSK1 66 3
BRSK2 67 2
MELK 46 15
NUAK1 27 0
CK1 delta 77 5
CK2 89 0
DYRK1A 93 11
DYRK2 69 6
DYRK3 102 17
NEK2a 93 1
NEK6 88 1
IKK beta 86 4
IKK epsilon 98 8
TBK1 73 3
PIM1 59 12
PIM2 89 3
PIM3 33 1
SRPK1 94 1
EF2K 96 5
EIF2AK3 93 4
HIPK1 33 7
HIPK2 63 0
HIPK3 126 1
CLK2 30 2
PAK2 94 7
PAK4 77 3
PAK5 107 10
PAK6 99 10
MST2 39 3
MST4 93 13
GCK 43 0
MINK1 45 5
MEKK1 97 11
MLK1 25 1
MLK3 32 10
TAO1 120 9
ASK1 80 1
TAK1 18 1
IRAK1 73 0
IRAK4 15 1
RIPK2 68 1
OSR1 94 0
TTK 87 7
MPSK1 99 11
Src 44 2
Lck 43 0
CSK 86 4
YES1 41 2
ABL 62 10
BTK 65 2
JAK2 42 1
SYK 72 10
ZAP70 100 3
TIE2 87 21
BRK 80 0
EPH-A2 81 2
EPH-A4 78 7
EPH-B1 78 1
EPH-B2 85 1
EPH-B3 111 9
EPH-B4 84 8
FGF-R1 20 3
HER4 85 2
IGF-1R 63 6
IR 45 16
IRR 52 3
TrkA 14 1
VEGFR1 13 2

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