Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PD 0325901-Cl (CI-1055-S) C16H14O4N2F2ClI 498.65 MEK1 WO2002006213 Caymanchem Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 3 2
MKK2 14 5
MKK6 61 15
ERK1 95 13
ERK2 91 2
JNK1 92 1
JNK2 90 4
JNK3 86 1
p38 alpha MAPK 102 5
p38 beta MAPK 129 5
p38 gamma MAPK 92 2
p38 delta MAPK 101 12
ERK8 90 15
RSK1 115 5
RSK2 95 7
PDK1 98 6
PKB alpha 104 2
PKB beta 92 1
SGK1 108 5
S6K1 110 21
PKA 110 0
ROCK 2 102 4
PRK2 84 1
PKC alpha 83 7
PKC gamma 95 12
PKC zeta 93 4
PKD1 90 9
STK33 102 4
MSK1 112 5
MNK1 92 11
MNK2 101 6
MAPKAP-K2 101 2
MAPKAP-K3 81 14
PRAK 94 1
CAMKK beta 108 2
CAMK1 95 1
SmMLCK 84 15
PHK 100 5
DAPK1 96 1
CHK1 115 22
CHK2 98 4
GSK3 beta 97 6
CDK2-Cyclin A 90 2
PLK1 104 5
Aurora A 106 6
Aurora B 86 1
TLK1 99 12
LKB1 112 3
AMPK 94 1
MARK1 83 3
MARK2 103 8
MARK3 75 4
MARK4 92 13
BRSK1 94 2
BRSK2 102 12
MELK 97 7
NUAK1 93 5
CK1 delta 88 6
CK2 103 20
DYRK1A 95 10
DYRK2 103 13
DYRK3 96 14
NEK2a 105 4
NEK6 91 6
IKK beta 101 10
IKK epsilon 101 8
TBK1 98 10
PIM1 62 3
PIM2 88 7
PIM3 68 5
SRPK1 103 0
EF2K 96 14
EIF2AK3 107 1
HIPK1 99 14
HIPK2 101 13
HIPK3 95 6
CLK2 88 0
PAK2 83 11
PAK4 80 7
PAK5 87 1
PAK6 98 12
MST2 96 10
MST4 103 11
GCK 104 5
MINK1 117 12
MEKK1 101 4
MLK1 74 8
MLK3 100 2
TAO1 111 13
ASK1 101 2
TAK1 101 2
IRAK1 84 1
IRAK4 92 5
RIPK2 81 8
OSR1 84 1
TTK 82 1
MPSK1 84 13
Src 80 11
Lck 98 10
CSK 89 5
YES1 91 5
ABL 108 0
BTK 101 2
JAK2 8 0
SYK 91 13
ZAP70 90 8
TIE2 94 1
BRK 112 10
EPH-A2 101 6
EPH-A4 98 4
EPH-B1 94 10
EPH-B2 111 3
EPH-B3 93 3
EPH-B4 90 11
FGF-R1 94 7
HER4 121 0
IGF-1R 81 8
IR 97 21
IRR 92 11
TrkA 88 13
VEGFR1 98 4
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 20 5
MKK2 48 1
MKK6 82 1
ERK1 98 13
ERK2 94 2
JNK1 91 4
JNK2 90 10
JNK3 73 3
p38 alpha MAPK 97 13
p38 beta MAPK 110 11
p38 gamma MAPK 83 9
p38 delta MAPK 93 5
ERK8 96 11
RSK1 103 7
RSK2 92 1
PDK1 90 13
PKB alpha 99 8
PKB beta 85 0
SGK1 94 2
S6K1 106 3
PKA 84 11
ROCK 2 77 5
PRK2 89 1
PKC alpha 89 12
PKC gamma 94 10
PKC zeta 96 7
PKD1 78 5
STK33 102 4
MSK1 84 3
MNK1 92 4
MNK2 94 5
MAPKAP-K2 87 1
MAPKAP-K3 98 1
PRAK 82 4
CAMKK beta 92 2
CAMK1 96 7
SmMLCK 81 8
PHK 95 9
DAPK1 92 4
CHK1 91 15
CHK2 85 6
GSK3 beta 93 12
CDK2-Cyclin A 92 8
PLK1 104 6
Aurora A 99 10
Aurora B 94 1
TLK1 92 10
LKB1 104 3
AMPK 92 5
MARK1 86 12
MARK2 97 14
MARK3 100 10
MARK4 93 5
BRSK1 86 7
BRSK2 111 5
MELK 91 14
NUAK1 91 5
CK1 delta 90 12
CK2 100 12
DYRK1A 94 11
DYRK2 94 4
DYRK3 93 9
NEK2a 92 8
NEK6 90 10
IKK beta 92 10
IKK epsilon 95 8
TBK1 88 0
PIM1 90 9
PIM2 100 7
PIM3 98 4
SRPK1 85 6
EF2K 92 15
EIF2AK3 109 9
HIPK1 109 7
HIPK2 94 4
HIPK3 82 12
CLK2 87 6
PAK2 92 2
PAK4 87 11
PAK5 102 5
PAK6 89 4
MST2 96 0
MST4 93 2
GCK 97 1
MINK1 98 9
MEKK1 88 5
MLK1 84 6
MLK3 98 7
TAO1 97 14
ASK1 98 7
TAK1 102 11
IRAK1 95 5
IRAK4 93 9
RIPK2 87 7
OSR1 98 10
TTK 96 10
MPSK1 84 0
Src 94 1
Lck 95 3
CSK 86 5
YES1 96 4
ABL 89 0
BTK 104 9
JAK2 8 1
SYK 114 8
ZAP70 99 10
TIE2 92 1
BRK 106 3
EPH-A2 90 10
EPH-A4 100 3
EPH-B1 103 7
EPH-B2 121 2
EPH-B3 108 2
EPH-B4 95 7
FGF-R1 94 9
HER4 97 5
IGF-1R 88 9
IR 104 2
IRR 94 8
TrkA 91 9
VEGFR1 90 1

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