Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
NVP-BEZ 235 C30H25Cl2N5O 542.46 PI3K, Akt, mTOR Maira S. Stauffer F. (2008) Mol. Cancer. Ther. 7 1851-1863. WO2008064093 Axon Download

Results as Barchart

View results as a bar chart
0.01µM
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 117 0
ERK1 98 3
ERK2 88 7
JNK1 103 10
JNK2 95 3
p38 alpha MAPK 85 5
p38 beta MAPK 99 5
p38 gamma MAPK 103 12
p38 delta MAPK 112 5
ERK8 74 4
RSK1 95 9
RSK2 133 4
PDK1 99 0
PKB alpha 100 14
PKB beta 89 1
SGK1 111 16
S6K1 114 14
PKA 96 9
ROCK 2 102 9
PRK2 80 18
PKC alpha 105 11
PKC zeta 97 0
PKD1 81 2
MSK1 104 2
MNK1 93 10
MNK2 98 1
MAPKAP-K2 91 13
PRAK 88 6
CAMKK beta 53 3
CAMK1 127 8
SmMLCK 105 2
PHK 108 6
CHK1 99 4
CHK2 107 15
GSK3 beta 95 13
CDK2-Cyclin A 71 11
PLK1 106 5
Aurora B 85 6
AMPK 90 0
MARK3 111 3
BRSK2 99 9
MELK 35 0
CK1 delta 88 7
CK2 106 9
DYRK1A 84 2
DYRK2 90 5
DYRK3 59 4
NEK2a 96 9
NEK6 111 0
IKK beta 98 3
IKK epsilon 107 14
TBK1 83 5
PIM1 91 16
PIM2 105 17
PIM3 88 19
SRPK1 116 1
EF2K 108 21
HIPK2 100 6
PAK4 92 2
PAK5 102 18
PAK6 105 1
MST2 48 4
MST4 97 15
Src 82 10
Lck 77 10
CSK 101 28
YES1 115 20
BTK 98 5
SYK 98 9
EPH-A2 111 4
EPH-B3 85 0
FGF-R1 111 20
IGF-1R 75 18
IR 110 17
IRR 78 4
VEGFR1 95 2
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 123 24
ERK1 88 9
ERK2 87 8
JNK1 98 1
JNK2 87 0
p38 alpha MAPK 83 2
p38 beta MAPK 86 2
p38 gamma MAPK 101 8
p38 delta MAPK 111 0
ERK8 88 0
RSK1 94 10
RSK2 116 21
PDK1 95 3
PKB alpha 86 3
PKB beta 96 0
SGK1 96 0
S6K1 104 6
PKA 92 7
ROCK 2 102 4
PRK2 78 16
PKC alpha 119 14
PKC zeta 101 4
PKD1 91 14
MSK1 97 4
MNK1 96 11
MNK2 101 1
MAPKAP-K2 76 1
PRAK 88 6
CAMKK beta 70 7
CAMK1 120 11
SmMLCK 99 4
PHK 99 0
CHK1 102 6
CHK2 97 18
GSK3 beta 96 0
CDK2-Cyclin A 73 9
PLK1 104 3
Aurora B 86 9
AMPK 98 1
MARK3 87 7
BRSK2 85 14
MELK 60 0
CK1 delta 83 0
CK2 102 11
DYRK1A 92 6
DYRK2 101 9
DYRK3 76 5
NEK2a 88 3
NEK6 114 7
IKK beta 98 3
IKK epsilon 101 6
TBK1 86 14
PIM1 92 0
PIM2 98 6
PIM3 104 8
SRPK1 116 3
EF2K 95 5
HIPK2 106 13
PAK4 89 7
PAK5 93 2
PAK6 108 6
MST2 76 6
MST4 102 9
Src 81 4
Lck 87 5
CSK 89 18
YES1 108 0
BTK 101 0
SYK 89 7
EPH-A2 119 5
EPH-B3 79 10
FGF-R1 117 7
IGF-1R 81 22
IR 104 11
IRR 84 3
VEGFR1 121 13
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 125 1
ERK1 89 4
ERK2 97 9
JNK1 99 4
JNK2 93 3
p38 alpha MAPK 89 4
p38 beta MAPK 90 9
p38 gamma MAPK 107 10
p38 delta MAPK 105 2
ERK8 96 0
RSK1 102 10
RSK2 114 11
PDK1 104 6
PKB alpha 98 9
PKB beta 92 10
SGK1 103 0
S6K1 116 2
PKA 98 4
ROCK 2 102 2
PRK2 91 8
PKC alpha 116 3
PKC zeta 103 0
PKD1 85 0
MSK1 107 6
MNK1 94 5
MNK2 151 23
MAPKAP-K2 88 9
PRAK 100 11
CAMKK beta 84 0
CAMK1 119 1
SmMLCK 96 15
PHK 94 13
CHK1 103 1
CHK2 101 14
GSK3 beta 104 2
CDK2-Cyclin A 93 7
PLK1 101 3
Aurora B 97 6
AMPK 99 12
MARK3 89 1
BRSK2 89 16
MELK 94 5
CK1 delta 91 8
CK2 113 11
DYRK1A 92 11
DYRK2 110 7
DYRK3 96 7
NEK2a 101 3
NEK6 109 7
IKK beta 101 4
IKK epsilon 106 13
TBK1 103 5
PIM1 98 2
PIM2 97 6
PIM3 112 11
SRPK1 113 0
EF2K 97 28
HIPK2 112 4
PAK4 94 6
PAK5 98 8
PAK6 104 8
MST2 87 0
MST4 108 11
Src 95 2
Lck 105 10
CSK 96 8
YES1 113 3
BTK 107 9
SYK 82 24
EPH-A2 132 16
EPH-B3 77 7
FGF-R1 126 23
IGF-1R 109 17
IR 99 7
IRR 95 2
VEGFR1 103 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 126 3
ERK1 89 3
ERK2 94 11
JNK1 94 6
JNK2 91 3
p38 alpha MAPK 87 1
p38 beta MAPK 85 3
p38 gamma MAPK 94 9
p38 delta MAPK 104 4
ERK8 60 6
RSK1 89 22
RSK2 93 9
PDK1 101 12
PKB alpha 87 3
PKB beta 97 15
SGK1 107 9
S6K1 104 1
PKA 98 4
ROCK 2 97 2
PRK2 67 8
PKC alpha 88 0
PKC zeta 101 2
PKD1 79 1
MSK1 95 4
MNK1 94 6
MNK2 143 58
MAPKAP-K2 78 6
PRAK 72 10
CAMKK beta 45 6
CAMK1 108 13
SmMLCK 101 4
PHK 96 1
CHK1 97 14
CHK2 79 0
GSK3 beta 84 19
CDK2-Cyclin A 59 1
PLK1 122 3
Aurora B 93 3
AMPK 92 3
MARK3 104 11
BRSK2 90 7
MELK 41 2
CK1 delta 83 4
CK2 107 5
DYRK1A 50 5
DYRK2 76 5
DYRK3 51 7
NEK2a 98 22
NEK6 25 5
IKK beta 98 9
IKK epsilon 94 9
TBK1 112 10
PIM1 60 6
PIM2 108 17
PIM3 88 21
SRPK1 97 3
EF2K 115 16
HIPK2 95 0
PAK4 91 8
PAK5 80 5
PAK6 114 6
MST2 45 1
MST4 98 4
Src 89 13
Lck 43 12
CSK 89 1
YES1 85 2
BTK 66 21
SYK 62 40
EPH-A2 96 6
EPH-B3 93 10
FGF-R1 60 0
IGF-1R 73 12
IR 98 12
IRR 74 0
VEGFR1 117 18

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