Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Nectrostatin-1 (Nec-1 inactive analog) C12H11N3OS 245.3 RIP Degterev A. Hitomi J. (2008) Nature Chemical Biology 4 313-321 WO2007075772 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 2 1
ERK1 82 14
ERK2 88 6
JNK1 107 9
JNK2 95 10
p38 alpha MAPK 82 7
p38 beta MAPK 95 4
p38 gamma MAPK 96 2
p38 delta MAPK 98 5
ERK8 94 11
RSK1 91 8
RSK2 100 1
PDK1 92 4
PKB alpha 90 8
PKB beta 97 8
SGK1 96 3
S6K1 100 11
PKA 95 1
ROCK 2 96 4
PRK2 82 2
PKC alpha 104 7
PKC zeta 83 7
PKD1 94 10
MSK1 87 11
MNK1 112 23
MNK2 97 8
MAPKAP-K2 96 13
PRAK 100 16
CAMKK beta 95 11
CAMK1 104 5
SmMLCK 94 7
PHK 96 0
CHK1 81 17
CHK2 94 6
GSK3 beta 92 2
CDK2-Cyclin A 94 4
PLK1 93 0
Aurora B 106 15
AMPK 95 0
MARK3 85 3
BRSK2 94 4
MELK 100 3
CK1 delta 115 19
CK2 93 1
DYRK1A 92 2
DYRK2 98 4
DYRK3 96 12
NEK2a 92 9
NEK6 87 13
IKK beta 210 140
IKK epsilon 93 0
TBK1 94 5
PIM1 93 1
PIM2 86 15
PIM3 95 5
SRPK1 98 1
EF2K 85 8
HIPK2 92 10
PAK4 106 2
PAK5 108 3
PAK6 98 2
MST2 102 6
MST4 108 1
Src 99 3
Lck 95 1
CSK 104 11
YES1 96 8
BTK 99 3
SYK 116 5
EPH-A2 86 6
EPH-B3 88 25
FGF-R1 80 1
IGF-1R 100 16
IR 103 2
IRR 90 1
VEGFR1 96 21
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 -2 2
ERK1 107 10
ERK2 80 14
JNK1 83 9
JNK2 91 9
p38 alpha MAPK 76 5
p38 beta MAPK 94 1
p38 gamma MAPK 103 5
p38 delta MAPK 94 2
ERK8 104 2
RSK1 80 9
RSK2 78 4
PDK1 86 2
PKB alpha 87 5
PKB beta 83 4
SGK1 87 5
S6K1 88 11
PKA 80 8
ROCK 2 83 8
PRK2 87 13
PKC alpha 97 12
PKC zeta 77 5
PKD1 78 5
MSK1 80 10
MNK1 85 3
MNK2 92 7
MAPKAP-K2 72 18
PRAK 89 5
CAMKK beta 79 3
CAMK1 89 13
SmMLCK 70 1
PHK 95 5
CHK1 82 24
CHK2 82 10
GSK3 beta 99 5
CDK2-Cyclin A 85 8
PLK1 97 0
Aurora B 100 7
AMPK 102 6
MARK3 92 0
BRSK2 79 4
MELK 84 10
CK1 delta 105 6
CK2 83 12
DYRK1A 85 9
DYRK2 82 4
DYRK3 78 1
NEK2a 87 3
NEK6 83 2
IKK beta 203 138
IKK epsilon 84 11
TBK1 106 4
PIM1 89 0
PIM2 97 13
PIM3 90 7
SRPK1 100 5
EF2K 75 0
HIPK2 82 24
PAK4 103 7
PAK5 97 5
PAK6 87 0
MST2 99 8
MST4 126 19
Src 94 6
Lck 74 8
CSK 101 13
YES1 85 2
BTK 84 3
SYK 92 5
EPH-A2 94 0
EPH-B3 81 1
FGF-R1 83 8
IGF-1R 113 4
IR 96 11
IRR 83 0
VEGFR1 89 7

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