Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Necrostatin-1 (Nec-1) C13H13N3OS 259.33 RIP Degterev A. Hitomi J. (2008) Nature Chemical Biology 4 313-321 WO2013013826 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 109 3
ERK1 93 17
ERK2 92 14
JNK1 79 14
JNK2 88 9
JNK3 110 8
p38 alpha MAPK 102 0
p38 beta MAPK 88 9
p38 gamma MAPK 101 2
p38 delta MAPK 102 1
ERK8 103 13
RSK1 92 2
RSK2 92 11
PDK1 92 5
PKB alpha 91 4
PKB beta 68 7
SGK1 98 3
S6K1 99 8
PKA 93 0
ROCK 2 97 7
PRK2 90 0
PKC alpha 96 0
PKC zeta 83 11
PKD1 86 5
MSK1 90 2
MNK1 78 5
MNK2 102 7
MAPKAP-K2 96 5
MAPKAP-K3 114 0
PRAK 87 6
CAMKK beta 86 1
CAMK1 94 10
SmMLCK 81 0
PHK 97 7
CHK1 103 2
CHK2 86 5
GSK3 beta 101 0
CDK2-Cyclin A 93 1
PLK1 88 0
Aurora A 102 4
Aurora B 106 0
LKB1 110 7
AMPK 102 2
MARK2 109 1
MARK3 98 0
MARK4 96 6
BRSK1 103 4
BRSK2 85 1
MELK 89 2
NUAK1 101 2
CK1 delta 101 5
CK2 87 6
DYRK1A 94 3
DYRK2 107 0
DYRK3 82 3
NEK2a 86 0
NEK6 119 0
IKK beta 96 1
IKK epsilon 86 7
TBK1 96 0
PIM1 94 1
PIM2 105 3
PIM3 85 8
SRPK1 89 10
EF2K 75 10
HIPK1 91 5
HIPK2 88 2
HIPK3 102 4
PAK2 94 1
PAK4 97 6
PAK5 99 4
PAK6 99 3
MST2 104 3
MST4 112 5
GCK 89 5
MINK1 99 11
MLK1 96 5
MLK3 109 5
IRAK4 99 6
RIPK2 112 7
TTK 106 4
Src 110 6
Lck 111 2
CSK 110 1
YES1 92 5
BTK 89 11
SYK 125 5
EPH-A2 96 5
EPH-B3 104 1
FGF-R1 100 2
HER4 104 0
IGF-1R 120 5
IR 106 12
IRR 87 1
VEGFR1 88 9
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 0
ERK1 88 20
ERK2 94 3
JNK1 85 1
JNK2 85 0
JNK3 99 5
p38 alpha MAPK 97 0
p38 beta MAPK 91 4
p38 gamma MAPK 111 3
p38 delta MAPK 96 4
ERK8 98 3
RSK1 80 1
RSK2 91 7
PDK1 90 11
PKB alpha 96 3
PKB beta 79 4
SGK1 99 15
S6K1 83 2
PKA 95 0
ROCK 2 96 3
PRK2 91 7
PKC alpha 97 10
PKC zeta 70 9
PKD1 89 8
MSK1 78 2
MNK1 86 2
MNK2 106 4
MAPKAP-K2 85 0
MAPKAP-K3 119 5
PRAK 88 1
CAMKK beta 91 0
CAMK1 94 13
SmMLCK 83 0
PHK 103 5
CHK1 109 5
CHK2 92 1
GSK3 beta 110 4
CDK2-Cyclin A 77 6
PLK1 81 7
Aurora A 101 9
Aurora B 104 5
LKB1 111 12
AMPK 94 1
MARK2 110 2
MARK3 94 0
MARK4 98 10
BRSK1 101 3
BRSK2 91 9
MELK 88 6
NUAK1 108 12
CK1 delta 94 1
CK2 95 3
DYRK1A 81 1
DYRK2 105 3
DYRK3 90 9
NEK2a 86 6
NEK6 89 10
IKK beta 95 5
IKK epsilon 90 0
TBK1 87 3
PIM1 87 3
PIM2 95 9
PIM3 88 2
SRPK1 93 8
EF2K 83 10
HIPK1 91 2
HIPK2 81 3
HIPK3 111 7
PAK2 102 1
PAK4 95 0
PAK5 119 5
PAK6 93 10
MST2 94 7
MST4 103 4
GCK 110 5
MINK1 103 11
MLK1 100 3
MLK3 109 1
IRAK4 109 8
RIPK2 159 48
TTK 98 8
Src 98 13
Lck 116 1
CSK 98 4
YES1 107 7
BTK 99 5
SYK 84 4
EPH-A2 102 3
EPH-B3 112 6
FGF-R1 93 12
HER4 109 12
IGF-1R 86 6
IR 88 7
IRR 81 7
VEGFR1 91 1

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