Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
ML-9, Hydrochloride C15H17ClN2O2S • HCl 361.3 MLCK Reig J.A. (1993) Neurochem. Res. 18 317 Nagatsu T. (1987) Biochem. Biophys. Res. Commun. 143 1045 WO1999041984 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
100µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 58 14
ERK2 96 7
JNK1 84 9
JNK3 76 1
p38 alpha MAPK 88 3
p38 beta MAPK 80 4
p38 gamma MAPK 91 4
p38 delta MAPK 65 13
ERK8 84 10
RSK1 43 8
RSK2 67 6
PDK1 96 7
PKB alpha 89 5
PKB beta 92 4
SGK1 82 11
S6K1 32 6
PKA 61 3
ROCK 2 28 0
PRK2 15 0
PKC alpha 72 2
PKD1 85 8
MSK1 30 1
MNK1 66 0
MNK2 81 9
MAPKAP-K2 85 4
MAPKAP-K3 97 6
PRAK 77 1
CAMK1 74 8
SmMLCK 95 40
PHK 95 5
CHK1 86 5
CHK2 77 5
GSK3 beta 80 5
CDK2-Cyclin A 57 2
PLK1 101 6
Aurora B 63 2
AMPK 85 14
MARK3 103 5
CK1 delta 91 3
CK2 78 4
DYRK1A 84 16
NEK2a 83 0
NEK6 103 14
NEK7 92 8
IKK beta 71 1
PIM2 63 0
SRPK1 87 16
EF2K 88 12
MST2 82 0
Src 82 3
Lck 75 0
CSK 80 8
Screening Concentration: 100µM
Kinase % Activity Remaining Standard Deviation
MKK1 75 3
ERK1 91 1
ERK2 91 8
JNK1 115 1
JNK2 92 4
JNK3 92 0
p38 alpha MAPK 92 6
p38 beta MAPK 86 1
p38 gamma MAPK 87 4
p38 delta MAPK 88 4
ERK8 50 2
RSK1 12 0
RSK2 19 1
PDK1 87 2
PKB alpha 44 4
PKB beta 58 3
SGK1 59 4
S6K1 13 1
PKA 25 5
ROCK 2 6 0
PRK2 1 1
PKC alpha 27 0
PKC zeta 50 5
PKD1 48 5
MSK1 11 3
MNK1 28 4
MNK2 40 2
MAPKAP-K2 69 4
MAPKAP-K3 79 2
PRAK 37 6
CAMKK alpha 108 1
CAMKK beta 75 1
CAMK1 17 3
SmMLCK 31 0
PHK 47 6
CHK1 94 2
CHK2 108 5
GSK3 beta 88 1
CDK2-Cyclin A 13 1
PLK1 98 7
Aurora B 57 2
Aurora C 73 3
AMPK 32 3
MARK3 130 1
BRSK2 2 5
MELK 66 7
CK1 delta 58 3
CK2 25 2
DYRK1A 46 5
DYRK2 79 6
DYRK3 30 2
NEK2a 94 3
NEK6 105 1
NEK7 122 6
IKK beta 67 1
PIM1 7 0
PIM2 43 6
PIM3 7 0
SRPK1 92 1
EF2K 122 1
HIPK2 43 1
HIPK3 68 5
PAK4 94 1
PAK5 85 4
PAK6 108 4
MST2 74 4
Src 100 1
Lck 81 1
CSK 78 2

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