Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
ML-7, Hydrochloride C15H17IN2O2S • HCl 452.7 MLCK Krarup T. (1998) Am. J. Physiol. 275 C239 Saitoh M. (1987) J. Biol. Chem. 262 7796 WO1999041984 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
2µM
20µM

Results as Table

Screening Concentration: 2µM
Kinase % Activity Remaining Standard Deviation
MKK1 97 0
ERK2 106 6
JNK1 98 0
JNK3 92 4
p38 alpha MAPK 82 16
p38 beta MAPK 88 1
p38 gamma MAPK 100 0
p38 delta MAPK 93 2
ERK8 95 3
RSK1 85 5
RSK2 97 10
PDK1 82 7
PKB alpha 101 2
PKB beta 93 5
SGK1 90 10
S6K1 77 1
PKA 108 3
ROCK 2 80 7
PRK2 57 8
PKC alpha 80 1
PKD1 101 9
MSK1 88 6
MNK1 79 4
MNK2 92 0
MAPKAP-K2 101 4
MAPKAP-K3 104 4
PRAK 91 11
CAMK1 88 6
SmMLCK 46 2
PHK 89 9
CHK1 86 0
CHK2 86 11
GSK3 beta 86 5
CDK2-Cyclin A 113 2
PLK1 107 14
Aurora B 82 1
AMPK 92 12
MARK3 103 3
CK1 delta 80 7
CK2 101 6
DYRK1A 88 12
NEK2a 86 0
NEK6 96 1
NEK7 94 17
IKK beta 96 3
PIM2 66 3
SRPK1 97 18
EF2K 102 6
MST2 89 9
Src 87 4
Lck 90 8
CSK 81 0
Screening Concentration: 20µM
Kinase % Activity Remaining Standard Deviation
MKK1 111 9
ERK1 109 1
ERK2 88 1
JNK1 103 1
JNK2 86 6
JNK3 86 0
p38 alpha MAPK 78 1
p38 beta MAPK 87 1
p38 gamma MAPK 87 3
p38 delta MAPK 60 1
ERK8 61 1
RSK1 64 1
RSK2 73 5
PDK1 96 0
PKB alpha 77 5
PKB beta 77 7
SGK1 95 6
S6K1 50 0
PKA 52 2
ROCK 2 54 3
PRK2 16 0
PKC alpha 76 2
PKC zeta 60 3
PKD1 75 1
MSK1 49 1
MNK1 55 6
MNK2 74 0
MAPKAP-K2 56 4
MAPKAP-K3 103 4
PRAK 55 8
CAMKK alpha 82 2
CAMKK beta 91 2
CAMK1 47 0
SmMLCK 12 0
PHK 55 0
CHK1 99 0
CHK2 111 4
GSK3 beta 78 1
CDK2-Cyclin A 67 5
PLK1 100 0
Aurora B 82 1
Aurora C 66 1
AMPK 78 4
MARK3 129 5
BRSK2 22 4
MELK 70 2
CK1 delta 85 5
CK2 37 7
DYRK1A 54 0
DYRK2 88 2
DYRK3 54 2
NEK2a 88 1
NEK6 103 5
NEK7 106 0
IKK beta 45 1
PIM1 11 0
PIM2 37 5
PIM3 7 0
SRPK1 98 5
EF2K 104 1
HIPK2 41 5
HIPK3 76 2
PAK4 89 2
PAK5 103 3
PAK6 98 6
MST2 90 1
Src 98 8
Lck 91 0
CSK 90 7

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