Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
LY333531 (Ruboxistaurin) C28H28IN4O3 .CH4O3S 582.73 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664 Tang S. (2008) Proteins 72(1) 447-60 WO2000053013 Axon Download

Results as Barchart

View results as a bar chart
0.01µM
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 28 6
ERK1 84 4
ERK2 93 0
JNK1 86 6
JNK2 98 0
JNK3 112 0
p38 alpha MAPK 96 8
p38 beta MAPK 108 2
p38 gamma MAPK 103 4
p38 delta MAPK 92 3
ERK8 92 6
RSK1 16 5
RSK2 12 2
PDK1 26 1
PKB alpha 89 7
PKB beta 82 4
SGK1 67 7
S6K1 64 7
PKA 60 1
ROCK 2 104 3
PRK2 51 4
PKC alpha 3 0
PKC zeta 90 7
PKD1 90 2
MSK1 49 8
MNK1 88 0
MNK2 100 1
MAPKAP-K2 114 3
MAPKAP-K3 93 2
PRAK 85 9
CAMKK alpha 114 5
CAMKK beta 58 5
CAMK1 85 1
SmMLCK 65 4
PHK 48 6
CHK1 63 0
CHK2 103 4
GSK3 beta 42 1
CDK2-Cyclin A 66 2
PLK1 81 0
Aurora B 65 2
Aurora C 78 5
AMPK 17 4
MARK3 68 2
BRSK2 67 2
MELK 58 9
CK1 delta 100 1
CK2 89 3
DYRK1A 76 1
DYRK2 89 1
DYRK3 80 6
NEK2a 84 4
NEK6 88 1
NEK7 107 7
IKK beta 83 6
IKK epsilon 31 0
TBK1 41 1
PIM1 4 0
PIM2 50 4
PIM3 2 0
SRPK1 90 1
EF2K 90 1
HIPK2 55 0
HIPK3 77 5
PAK4 73 8
PAK5 80 6
PAK6 85 4
MST2 34 1
MST4 70 5
Src 93 1
Lck 62 5
CSK 78 1
YES1 102 13
BTK 82 4
SYK 102 7
EPH-A2 100 13
EPH-B3 91 9
FGF-R1 103 26
IGF-1R 85 1
IR 101 15
IRR 69 4
VEGFR1 71 0
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 26 12
ERK1 100 7
ERK2 102 3
JNK1 65 3
JNK2 89 1
p38 alpha MAPK 86 2
p38 beta MAPK 113 13
p38 gamma MAPK 91 5
p38 delta MAPK 92 20
ERK8 22 2
RSK1 73 5
RSK2 5 2
PDK1 12 0
PKB alpha 87 0
PKB beta 78 4
SGK1 75 14
S6K1 12 1
PKA 82 0
ROCK 2 84 2
PRK2 22 1
PKC alpha 8 1
PKC zeta 57 1
PKD1 63 3
MSK1 11 0
MNK1 100 1
MNK2 89 23
MAPKAP-K2 102 7
PRAK 99 6
CAMKK beta 25 1
CAMK1 74 0
SmMLCK 33 13
PHK 25 0
CHK1 30 0
CHK2 46 2
GSK3 beta 12 0
CDK2-Cyclin A 50 1
PLK1 98 0
Aurora B 22 1
AMPK 48 3
MARK3 62 8
BRSK2 65 0
MELK 56 11
CK1 delta 121 7
CK2 112 2
DYRK1A 31 3
DYRK2 47 0
DYRK3 53 3
NEK2a 100 7
NEK6 93 11
IKK beta 87 1
IKK epsilon 7 1
TBK1 8 0
PIM1 1 0
PIM2 30 2
PIM3 5 1
SRPK1 101 2
EF2K 79 0
HIPK2 18 0
PAK4 88 1
PAK5 101 4
PAK6 88 3
MST2 10 0
MST4 29 2
Src 89 11
Lck 72 1
CSK 100 13
YES1 67 1
BTK 71 2
SYK 62 2
EPH-A2 86 6
EPH-B3 88 12
FGF-R1 57 4
IGF-1R 42 3
IR 99 9
IRR 55 14
VEGFR1 29 8
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 78 0
ERK1 101 6
ERK2 104 3
JNK1 89 2
JNK2 103 2
p38 alpha MAPK 95 6
p38 beta MAPK 93 4
p38 gamma MAPK 109 4
p38 delta MAPK 101 3
ERK8 84 17
RSK1 80 14
RSK2 77 5
PDK1 86 8
PKB alpha 101 17
PKB beta 90 10
SGK1 121 17
S6K1 96 15
PKA 104 0
ROCK 2 103 12
PRK2 98 5
PKC alpha 51 4
PKC zeta 95 4
PKD1 97 28
MSK1 81 13
MNK1 104 4
MNK2 86 6
MAPKAP-K2 102 14
PRAK 86 0
CAMKK beta 102 12
CAMK1 95 10
SmMLCK 95 12
PHK 112 7
CHK1 85 1
CHK2 92 3
GSK3 beta 89 9
CDK2-Cyclin A 87 9
PLK1 99 11
Aurora B 82 3
AMPK 91 15
MARK3 82 3
BRSK2 105 5
MELK 98 15
CK1 delta 121 19
CK2 117 1
DYRK1A 89 0
DYRK2 78 13
DYRK3 97 5
NEK2a 98 6
NEK6 87 5
IKK beta 100 8
IKK epsilon 82 8
TBK1 83 16
PIM1 69 0
PIM2 110 16
PIM3 58 14
SRPK1 97 8
EF2K 100 17
HIPK2 95 3
PAK4 96 3
PAK5 119 0
PAK6 100 0
MST2 92 7
MST4 97 0
Src 92 1
Lck 97 2
CSK 96 2
YES1 92 4
BTK 84 4
SYK 102 4
EPH-A2 109 10
EPH-B3 96 14
FGF-R1 108 16
IGF-1R 97 1
IR 110 12
IRR 79 3
VEGFR1 95 8

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