Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
LY294002 C19H17NO3 307.4 PI3K Baumann P. and West S.C. (1998) Proc. Natl. Acad. Sci. USA 95 14066 Cardone M.H. (1998) Science 282 1318 WO2013097266 Promega Download

Results as Barchart

View results as a bar chart
5µM
10µM
50µM

Results as Table

Screening Concentration: 50µM
Kinase % Activity Remaining Standard Deviation
MKK1 78 0
ERK1 88 1
ERK2 89 7
JNK1 91 1
JNK2 83 1
JNK3 80 0
p38 alpha MAPK 94 5
p38 beta MAPK 109 4
p38 gamma MAPK 95 1
p38 delta MAPK 66 5
ERK8 41 2
RSK1 36 1
RSK2 57 9
PDK1 74 7
PKB alpha 67 5
PKB beta 77 7
SGK1 67 0
S6K1 76 1
PKA 60 1
ROCK 2 84 6
PRK2 45 0
PKC alpha 49 3
PKC zeta 73 8
PKD1 78 0
MSK1 72 1
MNK1 77 2
MNK2 81 1
MAPKAP-K2 84 7
MAPKAP-K3 88 1
PRAK 55 2
CAMKK alpha 63 1
CAMKK beta 49 5
CAMK1 72 1
SmMLCK 43 2
PHK 42 5
CHK1 79 0
CHK2 103 2
GSK3 beta 8 0
CDK2-Cyclin A 60 1
PLK1 4 0
Aurora B 68 7
Aurora C 72 3
AMPK 85 2
MARK3 82 0
BRSK2 44 1
MELK 52 4
CK1 delta 32 0
CK2 2 3
DYRK1A 24 2
DYRK2 79 5
DYRK3 39 1
NEK2a 73 4
NEK6 69 1
NEK7 80 8
IKK beta 45 1
PIM1 3 1
PIM2 33 5
PIM3 2 0
SRPK1 71 1
EF2K 44 4
HIPK2 7 0
HIPK3 25 1
PAK4 70 6
PAK5 77 8
PAK6 80 7
MST2 61 1
Src 81 3
Lck 40 3
CSK 60 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 0
ERK1 85 7
ERK2 88 11
JNK1 92 5
JNK2 97 2
JNK3 86 2
p38 alpha MAPK 101 10
p38 beta MAPK 100 5
p38 gamma MAPK 89 3
p38 delta MAPK 101 13
ERK8 69 4
RSK1 92 3
RSK2 103 4
PDK1 88 2
PKB alpha 95 3
PKB beta 81 8
SGK1 104 4
S6K1 90 2
PKA 97 0
ROCK 2 89 10
PRK2 74 7
PKC alpha 76 6
PKC zeta 114 5
PKD1 105 2
MSK1 103 0
MNK1 77 5
MNK2 94 4
MAPKAP-K2 102 3
MAPKAP-K3 119 4
PRAK 83 6
CAMKK alpha 71 4
CAMKK beta 71 4
CAMK1 87 14
SmMLCK 88 7
PHK 94 9
CHK1 82 12
CHK2 83 0
GSK3 beta 37 3
CDK2-Cyclin A 80 1
PLK1 26 0
Aurora B 69 3
Aurora C 84 2
AMPK 96 7
MARK3 79 13
BRSK2 103 4
MELK 85 8
CK1 delta 56 3
CK2 23 5
DYRK1A 75 9
DYRK2 94 3
DYRK3 78 2
NEK2a 90 8
NEK6 103 4
NEK7 86 0
IKK beta 67 4
IKK epsilon 100 3
TBK1 102 4
PIM1 8 1
PIM2 65 1
PIM3 13 2
SRPK1 100 5
EF2K 83 3
HIPK2 38 1
HIPK3 77 2
PAK4 67 4
PAK5 92 5
PAK6 99 0
MST2 84 0
MST4 90 1
Src 105 10
Lck 96 2
CSK 103 2
YES1 90 3
SYK 115 9
EPH-A2 94 4
FGF-R1 95 2
IRR 55 8
Screening Concentration: 5µM
Kinase % Activity Remaining Standard Deviation
MKK1 86 4
ERK1 80 2
ERK2 93 3
JNK1 119 1
JNK2 105 1
JNK3 100 6
p38 alpha MAPK 112 13
p38 beta MAPK 97 10
p38 gamma MAPK 95 4
p38 delta MAPK 112 6
ERK8 87 5
RSK1 102 2
RSK2 128 3
PDK1 92 2
PKB alpha 111 10
PKB beta 87 6
SGK1 110 9
S6K1 92 2
PKA 102 6
ROCK 2 102 8
PRK2 74 3
PKC alpha 77 4
PKC zeta 102 0
PKD1 87 7
MSK1 101 8
MNK1 87 6
MNK2 108 3
MAPKAP-K2 117 0
MAPKAP-K3 120 1
PRAK 81 10
CAMKK beta 74 7
CAMK1 96 5
SmMLCK 119 8
PHK 99 3
CHK1 97 5
CHK2 81 0
GSK3 beta 56 3
CDK2-Cyclin A 44 1
PLK1 21 0
Aurora B 83 9
Aurora C 86 13
AMPK 105 0
MARK3 66 0
BRSK2 110 9
MELK 103 4
CK1 delta 78 0
CK2 40 7
DYRK1A 91 4
DYRK2 95 7
DYRK3 69 5
NEK2a 90 12
NEK6 97 7
NEK7 90 0
IKK beta 68 4
IKK epsilon 96 2
TBK1 116 5
PIM1 11 1
PIM2 94 3
PIM3 19 0
SRPK1 111 3
EF2K 114 1
HIPK2 43 9
HIPK3 93 4
PAK4 84 5
PAK5 107 15
PAK6 104 6
MST2 92 7
MST4 78 10
Src 98 5
Lck 103 6
CSK 118 10
YES1 95 2
SYK 110 5
EPH-A2 142 1
FGF-R1 94 10
IRR 72 0

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