Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
KN93 C26H29CIN2O4S 501 CaMKII Fan G.H. (1999) Mol. Pharmacol. 56 39 Tombes R.M. (1995) Cell Growth Differ. 6 1063 WO2009042906 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 94 4
MKK2 77 3
MKK6 95 1
ERK1 101 1
ERK2 109 12
JNK1 88 11
JNK2 91 4
JNK3 97 2
p38 alpha MAPK 94 6
p38 beta MAPK 89 4
p38 gamma MAPK 104 3
p38 delta MAPK 86 3
ERK8 97 7
RSK1 108 10
RSK2 76 8
PDK1 99 7
PKB alpha 89 6
PKB beta 83 1
SGK1 87 2
S6K1 96 0
PKA 98 2
ROCK 2 97 8
PRK2 78 3
PKC alpha 89 3
PKC zeta 107 1
PKD1 89 9
MSK1 84 4
MNK1 106 0
MNK2 101 1
MAPKAP-K2 88 0
MAPKAP-K3 78 6
PRAK 83 5
CAMKK beta 76 9
CAMK1 31 1
SmMLCK 39 4
PHK 113 9
DAPK1 82 9
CHK1 85 1
CHK2 108 2
GSK3 beta 70 2
CDK2-Cyclin A 108 14
PLK1 96 5
Aurora A 98 8
Aurora B 76 1
LKB1 85 2
AMPK 77 1
MARK1 82 11
MARK2 88 1
MARK3 103 10
MARK4 101 4
BRSK1 83 2
BRSK2 95 3
MELK 79 4
NUAK1 87 7
CK1 delta 101 8
CK2 117 13
DYRK1A 82 1
DYRK2 81 10
DYRK3 91 13
NEK2a 92 1
NEK6 103 13
IKK beta 89 1
IKK epsilon 85 8
TBK1 90 3
PIM1 53 1
PIM2 91 1
PIM3 71 2
SRPK1 91 1
EF2K 92 12
HIPK1 101 3
HIPK2 100 9
HIPK3 108 12
CLK2 70 2
PAK2 87 5
PAK4 96 1
PAK5 60 0
PAK6 100 13
MST2 66 1
MST4 106 12
GCK 96 3
MINK1 92 0
MEKK1 98 5
MLK1 88 1
MLK3 83 12
TAO1 87 5
ASK1 103 14
TAK1 76 13
IRAK4 79 12
RIPK2 94 1
TTK 89 9
Src 94 13
Lck 87 2
CSK 87 2
YES1 76 12
BTK 89 3
JAK2 101 9
SYK 64 5
EPH-A2 83 1
EPH-A4 100 6
EPH-B1 101 3
EPH-B2 90 12
EPH-B3 79 0
EPH-B4 96 6
FGF-R1 80 4
HER4 90 1
IGF-1R 66 11
IR 98 10
IRR 101 3
TrkA 41 2
VEGFR1 77 4
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 111 5
MKK2 93 0
MKK6 107 7
ERK1 117 2
ERK2 87 8
JNK1 94 2
JNK2 101 14
JNK3 96 5
p38 alpha MAPK 112 2
p38 beta MAPK 97 5
p38 gamma MAPK 102 14
p38 delta MAPK 93 7
ERK8 98 6
RSK1 117 14
RSK2 96 14
PDK1 97 5
PKB alpha 104 2
PKB beta 114 2
SGK1 102 2
S6K1 97 2
PKA 111 7
ROCK 2 95 8
PRK2 82 5
PKC alpha 98 3
PKC zeta 113 2
PKD1 99 7
MSK1 107 2
MNK1 100 8
MNK2 118 3
MAPKAP-K2 98 6
MAPKAP-K3 89 5
PRAK 102 1
CAMKK beta 83 3
CAMK1 86 6
SmMLCK 86 1
PHK 114 2
DAPK1 105 8
CHK1 86 1
CHK2 111 8
GSK3 beta 99 3
CDK2-Cyclin A 120 3
PLK1 92 1
Aurora A 106 4
Aurora B 83 5
LKB1 89 2
AMPK 88 4
MARK1 95 1
MARK2 84 7
MARK3 110 10
MARK4 103 1
BRSK1 109 1
BRSK2 93 11
MELK 96 15
NUAK1 104 11
CK1 delta 98 7
CK2 115 5
DYRK1A 110 6
DYRK2 104 5
DYRK3 109 10
NEK2a 109 6
NEK6 104 2
IKK beta 106 15
IKK epsilon 92 3
TBK1 87 5
PIM1 86 6
PIM2 103 10
PIM3 87 9
SRPK1 102 13
EF2K 106 9
HIPK1 102 2
HIPK2 105 2
HIPK3 91 2
CLK2 86 7
PAK2 101 8
PAK4 103 14
PAK5 92 3
PAK6 93 1
MST2 115 2
MST4 111 4
GCK 113 2
MINK1 110 7
MEKK1 93 2
MLK1 108 2
MLK3 96 1
TAO1 101 3
ASK1 106 4
TAK1 90 2
IRAK4 93 0
RIPK2 113 0
TTK 96 1
Src 103 3
Lck 102 5
CSK 107 12
YES1 92 8
BTK 91 4
JAK2 103 2
SYK 108 5
EPH-A2 93 2
EPH-A4 104 2
EPH-B1 101 2
EPH-B2 113 5
EPH-B3 98 5
EPH-B4 101 8
FGF-R1 94 1
HER4 94 1
IGF-1R 89 12
IR 97 11
IRR 106 3
TrkA 97 3
VEGFR1 94 6

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