Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
K252a C27H21N3O5 467.5 CaMKII Cools J. (2004) Cancer Res. 64 6385 Chin L.S. (1999) Cancer Invest. 17 391 WO2011114220 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
MKK1 0 1
Aurora A 0 0
PHK 1 0
CDK2-Cyclin A 1 0
DYRK1A 1 1
DYRK2 1 0
DYRK3 1 0
ERK8 1 0
RSK1 1 1
JAK2 1 1
RSK2 1 0
IRAK4 2 1
CLK2 2 0
MAPKAP-K2 2 1
MST2 2 0
IKK epsilon 2 1
PIM1 2 0
MEKK1 2 1
BRSK2 3 0
MLK3 3 0
ERK2 3 1
PKA 3 0
JNK1 3 1
IGF-1R 3 1
JNK3 3 0
PDK1 3 3
TBK1 3 1
MINK1 3 1
SmMLCK 4 1
TAK1 4 1
CHK2 4 0
HIPK2 4 1
RIPK2 4 0
MSK1 4 0
BTK 4 1
AMPK 4 2
GCK 4 2
PIM3 5 1
MELK 5 3
JNK2 5 0
PKC alpha 5 1
IR 5 0
Aurora B 5 2
PAK5 5 0
SYK 5 3
MARK3 5 1
DAPK1 6 2
FGF-R1 6 0
PRK2 6 1
Src 6 1
Lck 6 3
TrkA 6 1
PAK4 6 1
VEGFR1 6 1
MARK1 6 1
NUAK1 7 0
MARK4 7 1
SGK1 8 1
ERK1 8 1
p38 gamma MAPK 8 0
MNK2 8 4
PAK6 8 1
S6K1 9 0
CHK1 9 2
IKK beta 9 0
MST4 9 1
YES1 10 0
BRSK1 11 2
PAK2 11 2
LKB1 11 1
ROCK 2 12 2
PIM2 12 1
HER4 14 3
PRAK 14 2
GSK3 beta 15 0
PKD1 15 2
CAMK1 15 6
EPH-B3 16 0
PKC zeta 17 4
TTK 18 2
CAMKK beta 18 4
IRR 19 2
PKB alpha 19 2
EPH-A4 19 1
CSK 22 2
HIPK3 24 0
MARK2 24 9
EPH-A2 29 6
HIPK1 34 4
PKB beta 37 12
PLK1 41 1
p38 delta MAPK 41 1
MNK1 41 5
p38 beta MAPK 42 0
MLK1 43 52
EPH-B2 44 3
NEK2a 48 3
MAPKAP-K3 49 1
SRPK1 54 4
EPH-B4 75 13
CK2 81 9
CK1 delta 90 5
p38 alpha MAPK 91 6
NEK6 96 2
EF2K 100 5
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
PHK 0 0
MKK1 1 0
CHK1 1 0
PIM3 3 0
ERK8 3 0
MST2 4 2
PKD1 4 3
MAPKAP-K2 4 1
MELK 5 1
MNK2 6 0
RSK1 6 0
PDK1 7 2
DYRK3 7 1
PRK2 7 0
MARK3 8 0
VEGFR1 8 1
BTK 8 2
BRSK2 9 0
SYK 12 0
TBK1 12 6
SGK1 14 0
CHK2 14 20
AMPK 17 7
PIM1 18 0
IKK epsilon 19 0
PAK4 21 0
ERK1 24 3
DYRK1A 26 0
DYRK2 26 4
RSK2 28 8
S6K1 28 2
MSK1 28 7
MNK1 28 1
IRR 29 1
PAK5 29 0
PAK6 30 2
SmMLCK 32 2
CDK2-Cyclin A 41 3
Lck 43 1
ERK2 44 6
CAMK1 46 10
YES1 49 9
IGF-1R 49 8
FGF-R1 50 0
PKA 51 7
PIM2 51 11
Src 53 3
IKK beta 54 11
CAMKK beta 57 1
JNK2 59 2
HIPK2 59 6
p38 gamma MAPK 60 7
JNK1 65 12
GSK3 beta 66 5
ROCK 2 68 6
PLK1 72 8
PKC zeta 77 17
PKB beta 78 3
PKB alpha 82 4
CSK 84 10
PRAK 85 6
PKC alpha 86 2
p38 alpha MAPK 86 10
p38 delta MAPK 86 2
CK1 delta 86 1
SRPK1 92 2
NEK6 93 4
IR 94 6
EPH-A2 97 9
NEK2a 99 7
CK2 99 3
EF2K 102 10
p38 beta MAPK 110 22
EPH-B3 112 8
MST4 244 41
Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
DYRK1A 0 0
Aurora A 0 0
MAPKAP-K2 0 0
IGF-1R 0 0
MSK1 1 0
RSK2 1 1
MKK1 1 0
PAK6 1 0
MARK3 1 0
JNK1 1 0
IR 1 0
TrkA 2 1
NUAK1 2 0
VEGFR1 2 1
GSK3 beta 2 1
HIPK2 2 0
IRAK1 2 1
IKK epsilon 2 0
ERK2 2 1
PKA 2 0
PIM2 2 0
PIM3 2 0
JNK2 2 0
IRR 2 1
JAK2 3 3
PKC zeta 3 1
TAK1 3 3
CLK2 3 0
IRAK4 3 1
RSK1 3 0
TLK1 3 2
PAK4 3 1
FGF-R1 3 1
S6K1 3 0
CAMK1 3 1
GCK 3 0
BRSK2 3 1
HIPK3 4 0
BRK 4 3
DYRK3 4 1
PAK2 4 0
OSR1 4 0
PAK5 4 1
IKK beta 4 1
Src 4 1
PRK2 4 0
JNK3 5 0
CHK2 5 8
TAO1 5 1
SYK 5 1
DYRK2 5 6
PDK1 5 0
PKB alpha 5 1
MKK2 5 1
CAMKK beta 5 1
PIM1 5 0
PHK 5 2
BRSK1 5 3
ASK1 6 0
ZAP70 6 1
CDK2-Cyclin A 6 1
STK33 6 0
YES1 6 3
CHK1 7 0
HIPK1 7 0
p38 gamma MAPK 7 3
TIE2 7 1
EPH-A4 7 0
PRAK 7 1
PKD1 8 5
EPH-A2 8 1
EPH-B2 8 1
SGK1 8 3
DAPK1 8 0
MELK 9 4
ERK8 9 1
MARK4 9 0
Lck 10 2
MLK3 11 0
p38 delta MAPK 11 0
LKB1 11 1
MAPKAP-K3 11 3
TBK1 11 9
MPSK1 12 1
SmMLCK 12 2
HER4 13 0
RIPK2 14 4
AMPK 14 1
MST2 14 4
MST4 14 1
ERK1 14 5
EIF2AK3 15 1
MLK1 15 3
MARK1 16 1
SRPK1 16 1
PKC alpha 18 4
PKB beta 18 0
EPH-B1 19 1
TTK 19 1
BTK 19 4
NEK2a 20 5
MARK2 20 14
ROCK 2 21 6
EPH-B4 22 1
p38 beta MAPK 24 2
MINK1 24 1
PKC gamma 28 3
CSK 28 7
PLK1 31 6
MKK6 32 6
ABL 32 2
Aurora B 35 3
MNK2 39 2
MNK1 42 1
p38 alpha MAPK 49 6
EPH-B3 49 0
MEKK1 54 5
CK1 delta 63 23
CK2 72 1
NEK6 85 0
EF2K 105 1

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